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Background: Little evidence is available on how public transport features can impact on older people's health. The overarching aim of this paper is to evaluate socio-demographic, health and mobility-related factors correlated with health-related quality of life among people aged between 75 to 90 years old in three Swedish Municipalities. Methods: Within the SEBEM study, a cross-sectional survey us
ATT PLÖJA MYCKET, LITE ELLER INGET ALLS Vi blir fler och fler människor på vår planet, och år 2050 beräknas vi vara så många som 10 miljarder. Det innebär att vi måste kunna producera mer mat på en lika stor eller till och med mindre yta jämfört med idag. En stor del av den mat vi konsumerar produceras antingen direkt eller indirekt på åkrar runt om i världen. För lantbrukare som är inriktade på vSoil microorganisms are important for climate regulation as well as for plant nutrition. In agricultural soils the microorganisms are affected by management choices, like which type of tillage that is used. Moldboard plowing, the most common tillage practice, increases mineralization which leads to soil organic carbon (SOC) loss, and may thus reduce soil quality. Conservation tillage practices inf
Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen-like N-domain. Both domains are required for galectin-3 to induce cellular effects; a C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking the N-domain, binds cell surface glycoconjugates but does not induce cellular effects since cross-linking
Journal of Thrombosis and Haemostasis DOI: 10.1111/j.1538-7836.2011.04380
Acute myeloid leukemia (AML) is the most common leukemia in adults and is coupled to a poor prognosis, with a five-year overall survival of around 20% and a high risk of relapse. In AML, immature myeloid cells accumulate rapidly in the bone marrow impairing normal blood cell development. Current treatments fail to eradicate the leukemia stem cells, which is a self-renewing population of leukemia c
Introduction: The interaction between different product policies will be crucial for the further advancement of a coherent product policy framework. The Commission has stated that ‘the complex and interlocking approach needed to build a resource-efficient Europe can only be achieved with a policy mix that optimizes synergies and addresses trade-offs between different areas and policies’. In the co
A comprehensive understanding of the emotional mechanisms that motivate the symptoms of pediatric obsessive-compulsive disorder (OCD) is important for models of the etiology and treatment of the disorder. Existing models have emphasized the central role of fear, but recent research has highlighted that OCD may also be underpinned by incompleteness and disgust. However, whether incompleteness is re
Human papillomavirus type 16 (HPV16) is a cancer-causing virus that contributes to at least 70% of cervical cancer as well as to other anogenital cancers and head and neck cancer. Understanding HPV16 gene regulation is important to enhance our understanding of HPV16 infections and may contribute to development of antiviral drugs. In this study, we show that nucleosides/nucleoside analogues have th
Huntingtons sjukdom (HS) är en ärftlig fortskridande neurodegenerativ sjukdomsom orsakas av en förlängd CAG sekvens i huntingtin (HTT) genen, vilket leder till motoriska och kognitiva symptom samt personlighetsförändringar. Eftersom den muterade genen och proteinet den kodar för finns uttryckt i kroppens alla celler resulterar det i att även organ utanför hjärnan påverkas. En förhöjd ämnesomsättniHuntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. In clinical HD, body weight has been sh
The incidence of stroke and dementia are diverging across the world, rising for those in low-and middle-income countries and falling in those in high-income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability-adjusted life years globally (10%). Among
AbstractShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC). EHEC strains cause gastrointestinal infection and release Stx that can gain access to the circulation. Patients may develop hemolytic uremic syndrome with extensive kidney damage. In the first paper we investigated if blood cell-derived microvesicles released during EHEC infection contain Stx. Toxi
This paper discusses the experience of teaching William Shakespeare’s plays through performance and staging the plays with university students as part of the learning experience. The learning outcomes are treated in three sections – the first relating the effects of performance on the students’ linguistic proficiency, the second giving a few examples of how the students discover and learn to maste
Popular Abstract in SwedishVad är åldrande? När började man över huvud taget tala om ”åldrande”? När fick ordet ”pensionär” den betydelse vi är vana vid idag? I Åldrandet och språket studeras ord och uttryck för att ringa in vad man har menat med hög ålder och åldrande i Sverige under hundraårsperioden mellan 1875 och 1975. Frågor kring hög ålder och åldrande har stor aktualitet idag. I Sverige ocThis thesis analyses how old age and ageing were manifested and understood in Sweden from approximately 1875 to 1975. It thus aims to provide historical background to current debate about for instance the retirement age and how to best care for the elderly. Encyclopaedia entries from both the beginning and the end of this period describe ageing as a medical process of physical decline. Since much
The Gram-positive species Streptococcus pneumoniae is a human pathogen causing severe local and life-threatening invasive diseases associated with high mortality rates and death. We demonstrated recently that pneumococcal endopeptidase O (PepO) is an ubiquitously expressed, multifunctional plasminogen and fibronectin binding protein facilitating host cell invasion and evasion of innate immunity. I
Streptococcus pneumoniae infections remain a major cause of morbidity and mortality worldwide. Therefore a detailed understanding and characterization of the mechanism of host cell colonization and dissemination is critical in order to gain control over this versatile pathogen. Here we identified a novel 72 kDa pneumococcal protein endopeptidase O (PepO), as a plasminogen and fibronectin binding p
The activation of the complement system is a key initiating step in the protective innate immune-inflammatory response against injury, although it may also cause harm if left unchecked. The structurally related soluble complement inhibitors C4b-binding protein (C4BP) and factor H (FH) exert a tight regulation of the classical/lectin and alternative pathways of complement activation, respectively,
The Swedish legal scholar Tore Strömberg (1912-1993) is often characterized as the last true representative of the Uppsala school of legal thinking.
