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Purpose: Histologic grade, Nottingham Prognostic Index (NPI), estrogen receptor (ER) and progesterone receptor (PSR) status, and tumor size have previously been shown to be important prognostic indicators for distant recurrence of breast cancer. The purpose of this study was to compare the prognostic value of these factors with flow cytometric S-phase fraction (SPF), urokinase plasminogen activato
This paper presents the development of a character activation time prediction model for tongue-typing. This model is based on a modification of Fitts's law that is more suitable for tip-of-tongue selectivity tasks around the palatal area. The model was trained and evaluated with data from tongue-selectivity experiments using an inductive tongue-computer interface. It takes into account the movemen
Popular Abstract in Swedish Blodet är sammansatt av många olika typer av mogna celler som är ansvariga för specialiserade roller inom blodsystemet. Röda blodceller transporterar syre till kroppens celler, vita blodceller förser oss med försvar mot mikroorganismer och blodplättar ser till att stoppa blödningar. Nybildning av blodceller behövs kontinuerligt eftersom vissa celler lever bara i några dThe blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge
ABR-215757 (5757) is a quinoline-3-carboxamide (Q-compound) currently in clinical development for systemic sclerosis. Q-compounds have shown efficacy in several different models of autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis. However, the mechanism of action is still poorly understood. In this thesis we have tried to find the mechanism
The thesis aims to: (a) broaden the knowledge base that makes up the foundation for decisions with regard to how traffic law enforcement is best outlined, as well as increasing the understanding of how the shaping of different public instruments of control affects the chances of success; and (b) contribute to the development of theory and methodology within sociology of law. The relationship betwe
Nontypeable Haemophilus influenzae (NTHi) commonly causes local disease in the upper and lower respiratory tract and has recently been shown to interfere with both the classical and alternative pathways of complement activation. The terminal pathway of the complement system is regulated by vitronectin that is a component of both plasma and the extracellular matrix. In this study, we identify prote
Cutaneous human papillomaviruses (HPVs) are a heterogeneous, nonmonophyletic assembly, comprising about 50 characterized types and at least 133 isolates putatively representing new types. Their natural history of infection and potential association with nonmelanoma skin cancer are not well understood. Several PCR systems have been developed that amplify a broad spectrum of cutaneous HPVs. However,
The introduction of minimal residual disease (MRD) monitoring, in the Swedish national guidelines for acute lymphoblastic leukaemia, was evaluated in 35 patients aged 46-79 years (median 61), who were diagnosed from 2007 to 2011 and treated with high-intensity, block-based chemotherapy (ABCDV/VABA induction). Both a high complete remission rate (91 %) and acceptable overall survival (OS) rate (47
The recently described oomycete pathogen Phytophthora pisi causes root rot on pea and faba bean, while the closely related Phytophthora sojae is the causal agent of soybean root and stem rot. Differences in the pathogenicity factor repertoires that enable the two species to have distinct host specificity towards pea and soybean, were studied using tandem mass spectrometry in a global proteome stud
This paper reports the results of a search for strong production of supersymmetric particles in 20.1 fb(-1) of proton-proton collisions at a centre-of-mass energy of 8 TeV using the ATLAS detector at the LHC. The search is performed separately in events with either zero or at least one high-p (T) lepton (electron or muon), large missing transverse momentum, high jet multiplicity and at least three
A prospective clinical cohort study was established to investigate the humoral immune response in middle ear fluids (MEF) and serum against bacterial surface proteins in children suffering from recurrent acute otitis media (rAOM) and chronic otitis media with effusion (COME), using Luminex xMAP technology. The association between the humoral immune response and the presence of Moraxella catarrhali
BACKGROUND: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. METHODS: To evaluate the potential role of ge
Popular Abstract in SwedishEn del av Ortonys teorimodell angående den kognitiva strukturen hos emotioner testades på svenska gymnasieelever. Den del av teorin som användes i föreliggande studie handlade om de emotioner som tillskrivs den som utfört s.k. orätta handlingar. De eventuella känslor som man får när man utfört en orätt handling kallar Ortony för "self reproach" emotioner. Detta begrepp sThe purpose of this study was to test parts of Ortony's theoretical model relating to the cognitive structure of emotions in Swedish upper secondary school students. That part of the model, which was appropriate for the present study, deals with emotions attributed to the person who has perpetrated what is referred to as blameworthy actions. Ortony calls the possible emotions that you experience w
A nested case–control study of invasive and in situ cervical cancer was performed within a community-based cohort of 13 595 Taiwanese women assembled in 1991, with a follow-up period of 9 years. Baseline serum or plasma samples were analysed for antibodies against human papillomavirus (HPV) types 6, 16 and 18 and Chlamydia trachomatis. In total, 114 cases (42 incident cases identified during follo
Popular Abstract in Swedish Statlig intervention i ekonomin har, med varierande form och intensitet, varit ett allestädes närvarande fenomen i historien som haft genomgripande betydelse för handel, välfärd, internationella relationer och politiskt och ekonomiskt tänkande. Denna avhandling ger en omfattande analys av politiska ingrepp i den europeiska bilindustrin. Den skildrar politikens utvecklinState policy intervention in the economy has been a ubiquitous phenomenon in history. Varying in form and intensity, it has had a profound impact on trade, welfare, international relations, and political and economic thinking. This thesis provides an inclusive analysis of policy action in the European car industry. It details its development, processes, nature, and content and presents the story a
Air sampling and biological sampling have been performed to examine the exposure to nicotine in the Nicorette patch and Nicorette gum production at Pfizer Health AB in Helsingborg, Sweden. For this purpose stationary and personal sampling equipment have been used. At the Nicorette patch production, XAD-2 tubes were used to sample nicotine vapor and at the Nicorette gum production Teflon filters we
