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Volume loading of the right ventricle (RV) in patients with atrial septal defect (ASD) and patients with repaired Tetralogy of Fallot (rToF) affects the pumping mechanics of the left ventricle (LV). Intervention of the lesion will relieve the RV volume load however quantifiable impact on exercise capacity, arrhytmias or death are limited. A possible explanation could be remaining effects on the fu

There is a need of problematizing taken for granted assumptions in the conceptualization of collaborative housing when attempting to link collaborative housing and social integration. What are the difficulties and opportunities that migrants and non-migrants face in accessing collaborative housing projects? Addressing such type of questions will help to capture exclusionary processes affecting old

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+

Protein C is a vitamin K-dependent protein circulating in plasma as a zymogen to an anticoagulant serine protease. After its activation, protein C cleaves and inactivates coagulation factors Va and VIIIa. Human protein C is synthesized in liver and undergoes extensive post-translational modification during its synthesis. Recently, the protein C inhibitor was demonstrated to be synthesized in sever

The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. Epilepsy is a multifactorial ne

Popular Abstract in Swedish Luftvägsinfektioner som orsakas av bakterier och virus är en av de ledande orsakerna till sjukdom i världen. De kännetecknas av inflammation i svalg, hals, näsa, öron eller i lungorna. I näsa och hals finns en normalflora av bakterier som lever i samspel med sin värd och som normalt sett inte orsakar infektioner. Ibland kan dessa bakterier ändå orsaka sjukdom, som då imOuter membrane vesicles (OMV) have the size of nanoparticles and are released from the outer membrane of most Gram-negative bacteria. The OMV reflect the composition of the bacterial outer membrane, including lipids and virulence factors specific for the pathogen, and are involved in pathogenesis and bacterial survival. Moraxella catarrhalis and Haemophilus influenzae are Gram-negative bacterial s

Ovarian masses are common and a good pre-surgical assessment of their nature is important for adequate treatment. Bayesian Multi-Layer Perceptrons (MLPs) using the evidence procedure were used to predict whether tumors are malignant or not. Automatic Relevance Determination (ARD) is used to select the most relevant of the 40+ available variables. Cross-validation is used to select an optimal combi

Popular Abstract in Swedish Gangesfloden i Varanasi (Indien) anses samtidigt vara fullkomligt ren och svårt förorenad, beroende på vem som definierar dess egenskaper, brahminska religiösa specialister eller vetenskapligt orienterade miljöaktivister. Medan kontroversen fortgår, försöker några hinduiska religiösa ledare att anpassa sina traditioner till de nya miljöparadigmen, och deras förhållningsWhether the Ganges river in Varanasi (India) is pristinely pure or heavily polluted depends on by whom it qualities are defined, the Brahmin religious specialists in the city or the science oriented environmentalists. While the controversy continues, some Hindu religious leaders are searching for ways to adjust their respective traditions to the environmental paradigms, an initiative that reflects

Cholera toxin (CT) binds to GM1-ganglioside receptors present on all nucleated cells. Despite this, it is a very potent mucosal adjuvant that has a dramatic impact on immune cells, as well as nerve and epithelial cells, causing diarrhea. This fact has hampered our understanding of whether the adjuvanticity of CT is direct or indirect, as cells that bind CT may or may not be involved in its adjuvan

The objective of present work was to determine and compare the components of bioaerosol in several sectors of plant processing industries. The Study was conducted in 10 Facilities engaged in herb and grain processing, flax threshing, grain storing, baking, and cereals production. The air samples were taken on glass fibre litters with an AS-50 sampler. We determined the concentrations of airborne m

A prevalence of hepatitis C virus (HCV) antibodies of 12% was found in 276 patients from 11 dialysis units. Between zero and 22% of the patients in the different units were anti-HCV positive. The epidemiology of HCV was studied in two units during a 2 year period by antibody assays and the polymerase chain reaction and correlated with clinical manifestations. Two types of epidemiologic patterns we

In type-1 diabetes mellitus (T1DM) with diabetic nephropathy (DN), accumulation of abnormal proteins in the kidney and other tissues may derive from constitutive alterations of intracellular protein recognition, assembly, and turnover. We characterized the proteins involved in these functions in cultured skin fibroblasts from long-term T1DM patients with [DN+] or without [DN-] nephropathy but simi

Ovarian cancer is usually found at a late stage when the prognosis is often bad. Relative survival rates decrease with tumor stage or grade, and the 5-year survival rate for women with carcinoma is only 38%. Thus, there is a great need to find biomarkers that can be used to carry out routine screening, especially in high-risk patient groups. Here, we present a large-scale study of 64 tissue sample

Dendritic cells (DC) are the most potent APC in the organism. Immature dendritic cells (iDC) reside in the tissue where they capture pathogens whereas mature dendritic cells (mDC) are able to activate T cells in the lymph node. This dramatic functional change is mediated by an important genetic reprogramming. Glycosylation is the most common form of posttranslational modification of proteins and h

The effect of hyperthermia and/or nicotinamide (200 mg/kg of body weight) on the tumour growth delay induced by radiation was evaluated in a C3H mouse mammary adenocarcinoma. The study showed a radiosensitizing effect of hyperthermia and of nicotinamide but the combination of all three modalitites showed no increased tumor growth delay compared to hyperthermia and radiation alone. The tumour growt

Popular Abstract in Swedish Från 1980-talet har etiken diskuterats flitigt i samhället. Det har i samband med detta utvecklats etiska kommittéer. Etiska kommittéer är en typ av organ inom företag, branscher, professioner och andra organisationer som handhar etiska frågor och problem. De etiska kommittéerna fungerar rådgivande i etiska frågor, de kan fastställa etiska regler för en organisation ochThis thesis analyses the development of ethics committees from a sociology of law perspective and a social steerage perspective ("social control"). The main question is: Why are ethics committees established? Institutionalised ethics committee is a rather new phenomenon, which has become widely spread in the last 20 years. The study points out the public ethical debate since the 1980s as a major e

Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based on the lysophosphatidic acid (LPA) backbone. The binding of LPA to GPR92 was of high affinity (K(D) = 6.4 +/- 0.9 nM) and led to an increase in both phosphoinositide hydrolysis and cAMP production. GPR92 is atypical in tha

Immuno-supported liquid membrane (immuno-SLM) extraction is a new technique that makes use of antibody (Ab)–antigen interactions as the "extraction force" to drive the mass transfer in a selective way. In immuno-SLM, anti-analyte (Ag) Abs are introduced into the acceptor phase of the SLM unit to trap the Ag that passes from the flowing donor through the SLM into the stagnant acceptor. The amount o

The European Spallation Source (ESS), Lund, Sweden will be a 5MW long-pulse neutron spallation research facility and will enable new opportunities for researchers in the fields of life sciences, energy, environmental technology, cultural heritage and fundamental physics. Neutrons are produced by accelerating a high-energy proton beam into a rotating helium-cooled tungsten target. These neutrons pa