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Mixtures of two cationic proteins were used to prepare protein-DNA gel particles, employing associative phase separation and interfacial diffusion (Moran et al., 2009a). By mixing the two proteins, we have obtained particles that displayed higher loading efficiency and loading capacity values than those obtained in single-protein systems. However, nothing is known about the adverse effects on haem
Complement components and their cascade of reactions are important defense mechanisms within both innate and adaptive immunity. Many complement deficient patients still remain undiagnosed because of a lack of high throughput screening tools. Aiming towards neonatal proteome screening for immunodeficiencies, we used a multiplex profiling approach with antibody bead arrays to measure 9 complement pr
Stochastic differential equations driven by standard Brownian motion(s) or Lévy processes are by far the most popular models in mathematical finance, but are also frequently used in engineering and science. A key feature of the class of models is that the parameters are easy to interpret for anyone working with ordinary differential equations, making connections between statistics and other scient
Sepsis and invasive bacterial infection is a major cause of human disease and death worldwide. Streptococcus pyogenes is one of the major pathogens responsible for bacterial infections, which range from mild to severe and life threatening conditions. S. pyogenes contains a cell wall anchored M protein, which is an important virulence factor that can interact with many cells of the immune system. O
In this thesis, human behavior in rail tunnel fires is explored. Descriptive knowledge is presented related to the evacuation of passenger trains, and the subsequent tunnel evacuation to a safe location. More specifically, a theoretical framework that can aid the understanding of human behavior is identified, and its applicability to rail tunnels is demonstrated. In addition, new empirical data on
We have investigated the possibility of using the 2.45 GHz ISM band for communication between binaural hearing aids. The small size of a modern hearing aid makes it necessary to miniaturize the antennas to make this feasible. Two different types of hearing aid placements have been investigated: in the outer ear and in the ear canal. Both put strict demands on the size of the antenna, which have be
Background: Derivatized celluloses, such as methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), are of pharmaceutical importance and extensively employed in tablet matrices. Each batch of derivatized cellulose is thoroughly characterized before utilized in tablet formulations as batch-to-batch differences can affect drug release. The substitution pattern of the derivatized cellulose pol
Aims The aims were to (i) investigate initial construct validity of a tool for assessment of time allocation in occupational balance, and (ii) describe perceived occupational balance and its relationship with socio-demographics, well-being, and personal recovery among people with mental illness. Methods Satisfaction with Daily Occupations and Occupational Balance (SDO-OB) was administered to 226 p
Eae5 in rats was originally identified in two F-2 intercrosses, (DA x BN) and (E3 X DA), displaying linkage to CNS inflammation and disease severity in experimental autoimmune encephalomyelitis (EAE), respectively. This region overlaps with an arthritis locus, Pia4, which was also identified in the (E3 X DA) cross. Two congenic strains, BN.DA-Eae5 and BN.DA-Eae5.R1, encompassing the previously des
Two assertions made by the Eastern meditation traditions were investigated: (a) breath regulation is a prerequisite for attaining altered states of consciousness, (b) meditation leads to changes in cognitive processes and in personality. A deconditioning process was conceptualized involving the temporal lobes and the amygdala. Analyses of (a) the effects of carbon dioxide (CO2) inhalation and (b)
Popular Abstract in Swedish Införandet av 1993 års skogspolitiska beslut med ett jämställt miljö- och produktionsmål, belyser den historiskt befästa konflikten mellan allmänintresse och egenintresse: statens vilja och behov att styra produktion och avkastning kontra den enskilde skogsägarens rätt att själv bestämma över sin skog. Idag har denna konflikt styrt över mot en statligt uttalad målsättniThis dissertation analyzes the changes in the way Swedish forest policy has been developed and implemented in the past few decades. Its primary focus is on the period from the adoption of new legislation governing forestry in 1993 to date, though the historical antecedents of the more recent developments are also discussed. The dissertation focuses primarily on the interplay between changes in the
The Worldwide LHC Computing Grid (WLCG) is today comprised of a range of different types of resources such as cloud centers, large and small HPC centers, volunteer computing as well as the traditional grid resources. The Nordic Tier 1 (NT1) is a WLCG computing infrastructure distributed over the Nordic countries. The NT1 deploys the Nordugrid ARC-CE, which is non-intrusive and lightweight, origina
Background: There is variation in the care provided to men with metastatic prostate cancer (mPCa). There has been no previous set of quality indicators (QIs) regarding the management of men with mPCa. The objective of this study is to develop a set of international mPCa-specific QIs, which will enable global benchmarking of quality of care. Materials and methods: Potential QIs were identified thro
Background: When and how people were able to engage in everyday occupations changed suddenly with the coronavirus pandemic. Defined as a risk group due to their age, people 70 years and older in Sweden experienced confinement, as did older adults globally. Aim: To explore how doing, being, becoming, and belonging as dimensions of occupation were manifested in the lives of Swedish people 70 years o
OBJECTIVES: Patient-reported outcome measures (PROMs) are important for clinical practice and research. Given the high unmet need, our aim was to develop a comprehensive PROM for systemic sclerosis (SSc), jointly with patient experts. METHODS: This European Alliance of Associations for Rheumatology (EULAR)-endorsed project involved 11 European SSc centres. Relevant health dimensions were chosen an
Western Sierra Morena constitutes a singular link between the Roman provinces of Baetica and Lusitania, in terms of its physiography and historical development. This region, characterised by its rugged topography, forests, and abundant mineral resources, was decisively transformed after the Roman conquest. Such transformations are visible in the characteristics of the archaeological record and in
Objectives: To explore communication and engagement in everyday situations between persons with young-onset dementia (YOD) living in a nursing home (NH) and the caregivers. Methods: The study draws on ethnographic methods aligned with participatory design. Three residents with YOD living in a NH and eight staff members were recruited. A narrative approach was used for data collection and analysis.
Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. This indicates that there is still a lot that we do not understand about huntingtin. Similarly to other neurodegenerative d
