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Lysine-specific chemical crosslinking in combination with mass spectrometry is emerging as a tool for the structural characterization of protein complexes and protein-protein interactions. After tryptic digestion of crosslinked proteins there are thousands of peptides amenable to MSMS, of which only very few are crosslinked peptides of interest. Here we describe how the advantage offered by off-li
Popular Abstract in Swedish Partiklar som finns i luften och som vi andas in kan leda till negativa hälsoeffekter bland oss människor. I varje andetag andas vi in tusentals partiklar som tar sig ner i våra luftvägar. Det är normalt. Våra kroppar har försvarsmekanismer som tar hand om och oskadliggör partiklar som vi andas in och som fastnar i våra andningsvägar. Vid för höga halter av partiklar i BACKGROUND: Exposure to airborne particles in occupational environments can lead to both acute and long-term health effects in humans. To date, particle exposure limits in the air are typically given in terms of mass concentrations. But by only using mass concentration to characterize particles means there is a risk that other relevant characteristics, such as particle size and composition are con
Loss of genetic diversity threatens a species' adaptive potential and long-term resilience. Predicted to be extinct by 2038, the orange-bellied parrot (Neophema chrysogaster) is a critically endangered migratory bird threatened by numerous viral, bacterial and fungal diseases. The species has undergone multiple population crashes, reaching a low of three wild-born females and 13 males in 2016, and
The Öresund – the strait between eastern Denmark and southwestern Sweden – is an ancient focal point for trade, conflict, and cooperation in Northern Europe. The control of the strait has been of utmost strategic importance in Northern Europe over the centuries, involving several wars between Denmark and Sweden. During the 19th and 20th centuries, a decidedly more peaceful relationship developed
Purpose: Children with delayed reconstruction of esophageal atresia (DREA) have a high risk of morbidity. The aim of this study was to determine the prevalence of feeding difficulties in children with DREA, differences to children with primary anastomosis (PA) and identify risk factors for feeding difficulties in children with DREA. Methods: Parents of 30 children with DREA, born 2001–2018, were r
Aim: Tumour stage is the most important prognostic factor in colon cancer. The aim of this study was to examine the impact on the quality of pathology by the use of a standardized PAD protocol. Method: A standardized PAD protocol for colorectal cancer was developed and all patients subjected to colon resection due to adenocarcinomas between 2004 and 2006 were analyzed concerning lymph node status,
The cloud-nucleating properties of the atmospheric aerosol were studied in an area under strong influence of vegetation burning. The measurements were part of Large-Scale Biosphere Atmosphere Experiment in Amazonia-Smoke Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) and were carried out at a ground site located in the state of Rondonia in southwestern Amazonia, Brazil, September to November 2
We examined the effects of the immunophilin ligands and calcineurin inhibitors FK506 and cyclosporin A on the survival of rat embryonic dopamine (tyrosine hydroxylase (TH)-immunoreactive) neurons. The protective effects of FK506 and cyclosporin A were first studied in dissociated mesencephalic cell cultures subjected to serum deprivation. Significant increases in both the total number of surviving
Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served
We have critically examined and compared various ways to obtain standard harmonic molecular mechanics (MM) force-field parameters for metal sites in proteins, using the 12 most common Zn2+ sites as test cases. We show that the parametrization of metal sites is hard to treat with automatic methods. The choice of method is a compromise between speed and accuracy and therefore depends on the intended
The most frequently used, and effective, treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB), which results in rapid remission of T2D in most cases. To what extent this is accounted for by weight loss or other factors remains elusive. To gain insight into these mechanisms, we investigated the effects of RYGB on ß-cell function and ß-cell mass in the pig, a species highly remini
The private garden is one of the most important sites for people’s everyday interactions with nature. Although sometimes just consisting of a lawn, a few shrubs and maybe a flower bed, it provides a number of situations where the owner has to reflect on and handle biodiversity and sustainability issues in relation to modern lifestyle. This paper will discuss different aspects of sustainability in
In trying to get products out to the market in promotional or display packaging, companies have the option of turning to a contract packager. The purpose of this thesis is to present the area of contract packaging, specifically discussing the internal factors that make a contract packager an attractive actor to outsource packaging of products to and also to find out how a contract packager can aff
The field of phylogenomics has emerged during the last five years, as the number of fully or partially sequenced genomes has increased rapidly. Using whole genomes for phylogenetic studies greatly increases the accuracy of the trees determined, and can potentially resolve phylogenetic questions that could not be resolved bu studies using only a few gene sequences. In the current thesis selected
Objective. To make an inventory of quality and content of currently available and published sets of health care quality indicators (HCQIs) for RA and OA.Methods. A systematic review was performed for documents on the development and/or a description of HCQIs for the management of patients with RA and/or OA, using the PubMed, EMBASE, Web of Science, Cochrane and CINAHL databases up to 1 December 20
Abstract Gastrostomy operations are performed on children referred to the pediatric surgical clinic without being influenced by the patient’s state of nutrition. This has been motivated by the idea that a gastrostomy would enable a fast and secure improvement in this regard. The question arises whether an improvement in the preoperative nutritional status would reduce the number of postoperative c
The number of electrically driven loads in a modern vehicle is constantly increasing. Many loads that former were mechanically driven will in the future be driven by electricity. This implies that a number of electronic systems have to be packed together in the limited space in a vehicle. When different electronic systems are placed close to each other, there is always a risk for electromagnetic i
Whilst Building Information Modelling (BIM) promises significant improvements in construction quality and efficiency, current contractual models do not encourage its use; indeed actively inhibit the collaboration at its core. To help bring BIM into the mainstream, it is claimed we need to re-craft existing contractual relationships to facilitate collaborative decision making and to equitably alloc
Popular Abstract in Swedish C-Med 100, en naturmedicin med immunomodulerande egenskaper Vårt immunsystem skyddar oss mot infektioner från bakterier, virus och parasiter. För att detta ska fungera behövs många olika egenskaper och idag delas immunsystemet in i två delar, en ospecifik och en specifik. Den ospecifika delen består av hud, slemhinnor, magsyra och olika celler som snabbt tar sig till etExtracts from the bark of the vine Uncaria tomentosa have anti-inflammatory, antiviral, antimutagenic and antioxidant effects. In this study, we evaluate the effects of an Uncaria tomentosa extract, denoted C-Med 100, on the cellular level of the immune system both in vivo and in vitro. Our results indicated that lymphocytes had significantly prolonged half life after in vivo supplementation with
We review the current knowledge on biodiversity in soils, its role in ecosystem processes, its importance for human purposes, and its resilience against stress and disturbance. The number of existing species is vastly higher than the number described, even in the macroscopically visible taxa, and biogeographical syntheses are largely lacking. A major effort in taxonomy and the training of a new ge
