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This thesis consists of two parts with the common theme of statistical modelling in chemistry. The first part is concerned with applications in nuclear magnetic resonance (NMR) spectroscopy, while the second part deals with applications in polymerase chain reaction (PCR). The problems considered in the first part all have their origin in protein NMR spectroscopy, although they are treated mainly
Estrogen and progesterone are key regulators of normal breast epithelial cell proliferation and differentiation. They are also involved in the initiation and progression of breast tumorigenesis. Several experimental studies have demonstrated that steroid hormones affect cell cycle proteins associated with tumor initiation and progression. Hormone replacement therapy (HT) is widely used to alleviat
Although it is possible to measure respiration by intact tissues it is often useful to be able to isolate uncontaminated, intact and functional mitochondria. Here, we will consider some of the principles for isolating cell organelles. This discussion is not meant to be exhaustive nor will it be a cookbook with recipes to be followed step-by-step. Useful general references are Douce 1985, Møller et
For many assembly operations force control is needed, but force sensors may be expensive and add mass to the system. An alternative is to use the motor torques, though friction causes large disturbances. The Coulomb friction can be quite well known when a joint is moving, but has much larger uncertainties for velocities close to zero. This paper presents a method for force estimation that account
Human endogenous retroviruses (HERVs) are estimated to represent at least 1% of the human genome. An HERV-H env SU sequence (HERV-H19) was used to screen the high-throughput (htgs) and nonredundant (nr) databases for other HERV-H SU open reading frames (ORFs) and thus possible functional proteins. Using PCR with primers derived from HERV-H19 SU, we also obtained several new sequences with ORFs fro
A novel technique to identify and split clusters created by multiple charged particles in the ATLAS pixel detector using a set of artificial neural networks is presented. Such merged clusters are a common feature of tracks originating from highly energetic objects, such as jets. Neural networks are trained using Monte Carlo samples produced with a detailed detector simulation. This technique repla
Background and Aims: Radionuclide therapy is systemic, targeted radiotherapy. As such, we can apply the basic principles of radiobiology used in everyday practice in radiation oncology, as a means of tailoring the treatment to each patient and optimizing the balance between efficacy and toxicity. The most common type of radionuclide therapy used for the treatment of neuroendocrine tumors, is 177Lu
Particulate matter with an aerodynamic diameter less than 10 µm (PM10) from car disc brakes contribute up to 50% of the total non-exhaust emissions from road transport in the EU. These emissions come from the wear of the pad and rotor contact surfaces. Yet few studies have reported contact pressures and offered sliding speed maps of the friction, wear, and particle emission performance of disc bra
Karst är landskap och karakteristika som är viktiga både ur hydrologisk och geologisk synpunkt och som är utvecklade genom vattnets vittring av oftast karbonathaltiga stenar. Denna uppsats kartlägger världens karstområden, beskriver egenskaper av karst och karsthydrologi och strävar efter att definiera problem och möjligheter med vattenhantering i karstlandskap. Akvifärer i karst skiljer sig i månSummary: Water is, and will in the near future be even more, a key issue for the global development, and for issues concerning equal rigts for all mankind. Water is a necessity and a scarce resource in great parts of the world and it therefore exists a great need for development and management of the world’s waters. With fresh waters being increasingly accentuated for their importance in global de
A multidisciplinary scientific research center harnessing the world’s most powerful neutron source is going to be built in Lund: ESS, The European Spallation Source. Researchers will be able to study the materials of everyday life in all their rich diversity – from plastics and proteins to medicines and molecules – in order to understand how they are built up and how they work. ESS will become a h
BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this syst
BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.METHODS: For countri
Librarians like to think that libraries contribute substantially to the progress of research. However, libraries still seem to have serious problems getting integrated in their parent organization on equal terms with other parts of that organization. The degree of integration of the library is thus the main topic of this thesis and the purpose is to examine how the interaction between librarians a
This thesis investigates advanced Swedish students’ development of three grammatical phenomena: subject-verb concord, prepositions and article use in compositions and translations. In order to describe the students’ development of these categories, actual errors are related to potential errors forming so called ‘error scores’. When the error score for the first test opportunity is compared with th
Background: Empowered women have improved decision-making capacity and can demand equal access to health services. Community-based interventions based on building women’s groups for awareness generation on maternal and child health (MCH) are the best and cost-effective approaches in improving their access to health services. The present study evaluated a community-based intervention aimed at impro
On the basis of the GBD (Global Burden of Disease) 2013 Study, this article provides an overview of the global, regional, and country-specific burden of stroke by sex and age groups, including trends in stroke burden from 1990 to 2013, and outlines recommended measures to reduce stroke burden. It shows that although stroke incidence, prevalence, mortality, and disability-adjusted life-years rates
STUDY QUESTION Does an intensive weight reduction programme prior to IVF increase live birth rates for infertile obese women? SUMMARY ANSWER An intensive weight reduction programme resulted in a large weight loss but did not substantially affect live birth rates in obese women scheduled for IVF. WHAT IS ALREADY KNOWN Among obese women, fertility and obstetric outcomes are influenced negatively wit
