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Aggrecans and PG-M/versicans represent two newly defined families of hyaluronan-binding proteoglycans for which the function is still poorly understood. Using the avian neural crest as a model system, we have examined the molecular mechanisms entailed in the cell-proteoglycan interaction during embryonic cell motility. Both the primary cartilage aggrecan of the avian embryo (PG-H/aggrecan) and the
Objective - To investigate the feasibility of monophasic action potential ( MAP) mapping using an electro-anatomical mapping system ( CARTO) in obtaining information on global dispersion of atrial repolarization and to evaluate the role of dispersion of repolarization in the genesis of paroxysmal atrial fibrillation ( PAF). Methods and results - Right atrial MAPs were recorded from 53 +/- 18 sites
Aims: A study was undertaken to investigate the relationship between country of birth, time in Sweden, and overweight and obesity. Methods: Approximately 4,000 people aged 20-80 participated in a cross-sectional survey in 1994. The ethnic differences in overweight and obesity were analysed in a multivariate logistic regression analysis adjusting for age and education. The effect of number of years
Atypical lipomatous tumor (ALT), an intermediate malignant neoplasm of soft tissues, is characterized by the presence of supernumerary ring and giant marker chromosomes. These supernumerary chromosomes consistently contain amplified 12q-material in association with amplified segments from a variety of other chromosomes. However, a few cases of ALT with other types of chromosomal rearrangements hav
Introduction. The aetiology and pathogenesis of ulcerative colitis (UC) are essentially unknown. Galectins are carbohydrate-binding lectins involved in a large number of physiological and pathophysiological processes. Little is known about the role of galectins in human UC. In this immunohistochemical exploratory study, both epithelial and inflammatory cell galectin expression were studied in pati
Recent studies have highlighted the involvement of rare (<1% frequency) copy-number variations and point mutations in the genetic etiology of autism spectrum disorder (ASD); these variants particularly affect genes involved in the neuronal synaptic complex. The SHANK gene family consists of three members (SHANK1, SHANK2, and SHANK3), which encode scaffolding proteins required for the proper format
Neutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into account. In the INSIGHT study, we analyzed the association between F8 mutation and inhibitor development in pat
In this study, different flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenases (FADGDHs) were characterized electrochemically after "wiring" them with an osmium redox polymer [Os(4,4'-dimethyl-2,2'-bipyridine)(2)(PVI)(10)Cl](+) on graphite electrodes. One tested FADGDH was that recently discovered in Glomerella cingulata (GcGDH), another was the recombinant form expressed in Pichia pa
The purpose of this study was to investigate whether the gut mucosa is a reservoir for enterovirus persistence in patients with type 1 diabetes. Small intestine biopsy samples from 25 individuals at different stages of type 1 diabetes, 21 control individuals and 27 individuals with coeliac disease were analysed for the presence of enterovirus RNA by using both radioactive in-situ hybridisation and
The roof dual bound for quadratic unconstrained binary optimization is the basis for several methods for efficiently computing the solution to many hard combinatorial problems. It works by constructing the tightest possible lower-bounding submodular function, and instead of minimizing the original objective function, the relaxation is minimized. However, for higher-order problems the technique has
Fishing activity has been suggested to affect food web structure and functioning of aquatic ecosystems. Based on changes of the mean trophic level index of fishery catch, the present study demonstrates long-term ecosystem impacts of fisheries in Lake Chaohu, a freshwater lake in Anhui Province, China. The decline of mean trophic level (MTL) in the last five decades, coupled with a dramatic increas
A number of amyloidogenic variants of apolipoprotein A-I (apoA-I) have been discovered but most have not been analyzed. Previously, we showed that the G26R mutation of apoA-I leads to increased β-strand structure, increased N-terminal protease susceptibility and increased fibril formation after several days of incubation. In vivo, this and other variants mutated in the N-terminal domain (residues
Secretagogin is a calcium-binding protein whose expression is characterised in neuroendocrine, pancreatic, and retinal cells. We have used an array-based proteomic approach with the prokaryotically expressed human protein array (hEx1) and the eukaryotically expressed human protein array (Protoarray) to identify novel calcium-regulated interaction networks of secretagogin. Screening of these arrays
1. Self-medication is an ability to consume or otherwise contact biologically active organic compounds specifically for the purpose of helping to clear a (parasitic) infection or reduce its symptoms. Consumption of these compounds may either take place before the infection is contracted (prophylactic consumption) or after the infection is contracted (therapeutic consumption). 2. An important insig
Sorption filters based on granular activated carbon, bone meal and iron fines were tested for their efficiency of removing metals from landfill leachate. Removal of Al, As, Ca, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Sr and Zn were studied in a laboratory scale setup. Activated carbon removed more than 90% of Co, Cr, Cu, Fe, Mn and Ni. Ca, Pb, Sr and Zn were removed but less efficiently. Bone
Circadian clocks are biological timekeepers that allow living cells to time their activity in anticipation of predictable daily changes in light and other environmental factors. The complexity of the circadian clock in higher plants makes it difficult to understand the role of individual genes or molecular interactions, and mathematical modelling has been useful in guiding clock research in model
Ecophysiological research aiming at explaining the causes and consequences of variation in individual condition, health state, and allostasis is traditionally performed on captive animals under controlled laboratory conditions. The question about how captivity per se affects studied parameters is therefore of central importance for generalizing the information gained from such studies. We addresse
Abstract Objectives. The Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART) collects data to support the improvement of care for heart disease. Design. SWEDEHEART collects on-line data from consecutive patients treated at any coronary care unit n = (74), followed for secondary prevention, undergoing a
The concept of disaster risk reduction has gained more and more attention since the end of the 20th century due to the exponential increased loss of human lives and material losses, without any evidence of increased number of hazardous events. Instead of just managing disastrous events, a greater emphasis has been put on prevention efforts; an understanding of underlying drivers and vulnerabilitie
In this paper we want to draw attention to the relationship between economical and cultural issues in the publishing industry by examining in what way these issues have been dealt with at Albert Bonniers Förlag, a most dominant player on the Swedish book market since 1837. Our purpose is to reveal how intimately interconnected economical and aesthetical matters are in the publishing industry at la
