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The dynamic properties of the actin cytoskeleton in smooth muscle cells play an important role in a number of cardiovascular disease states. The state of actin does not only mediate mechanical stability and contractile function but can also regulate gene expression via myocardin related transcription factors (MRTFs). These transcriptional co-activators regulate genes encoding contractile and cytos
This dissertation consists of three empirical essays concerning social norms and their effect on economic outcomes. Each essays discusses a seperate subject. The first paper, Breaking the Glass Ceiling: Gender Norms and Women Executives in the United States studies social norms as a distal cause of differences between genders in corporate executive recruitment strategies. Using census-level panel This dissertation consists of three empirical essays concerning social norms and their effect on economic outcomes. Each essays discusses a seperate subject. The first paper, Breaking the Glass Ceiling: Gender Norms and Women Executives in the United States studies social norms as a distal cause of differences between genders in corporate executive recruitment strategies. Using census-level panel
Background and aims After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lip
Popular Abstract in Swedish Föräldrars involvering i skolan har under de senaste decennierna betonats allt mer i skoldebatten. Länge betraktades skolutbildning som enbart ett samhälleligt ansvar, vilket ofta medförde ett markerat avståndstagande från familjen och föräldrarna. Likt andra samhälleliga servicefunktioner har emellertid också skolan i sitt förhållande till sina användare undergått en fOver the last two decades, educational reforms have stimulated an enormous growth in innovative school thinking, effecting both independent schools and mainstream education. Parents and interest groups, previously excluded from general pedagogic practice and planning, are now faced with new opportunities and responsibilities. Parents “invest” in these newly won options in very different ways. Fail
Popular Abstract in Swedish En av de viktigaste substanserna i vår kropp är proteiner, också kallade äggviteämnen. Proteiner har en mängd olika uppgifter i kroppen, de finns i våra celler där de har olika uppgifter såsom att fungera som enzymer, transportörer, signalsubstanser, eller som skyddsfaktorer. Proteiner ingår också som viktiga beståndsdelar i vävnaderna mellan cellerna och finns dessutomPathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ
Classical evolutionary life history concerns questions such as optimal timing of maturation, life span and number of offspring. These questions have mostly been studied theoretically under the assumption that the environment is stable and without taking into account frequency and density dependence. Life history theory is the basis for my thesis, in which I have studied the evolution of different
Popular Abstract in Swedish Hårdvara och algoritmer för ett inbyggt videoövervakningssystem presenteras i denna avhandling. För att verifiera systemet så har en prototyp byggts.The demands on video surveillance systems are rapidly increasing regarding parameters such as frame rate and resolution. Furthermore, with an ever increasing number of video streams, an automated process for extracting relevant information is required. Due to the large amount of input data and the computational complexity of the algorithms, software implementations are not sufficient to sustain re
PURPOSE: Activation of soluble guanylate cyclase with a subsequent increase in intracellular levels of cyclic guanosine monophosphate is necessary for normal erection. In vascular tissue 3(5'-hydroxymethyl-2'-furyl-1-benzyl indazole (YC-1) (Abbott Laboratories, North Chicago, Illinois) has been shown to stimulate soluble guanylate cyclase independent of nitric oxide. We studied whether YC-1 modula
Background: OncoMasTR is a new multigene prognostic test that was discovered via a novel transcriptional network analysis method that identified upstream Master Transcription Regulators (MTRs), which regulate previously identified prognostic biomarkers. The optimised OncoMasTR signature incorporating clinicopathological information has been shown to be significantly prognostic for predicting dista
Type 2 diabetes has become a leading health problem throughout the world. The escalating epidemic of type 2 diabetes is believed to result from a collision between inherent biological susceptibilities (genotypes) and a shift toward dietary habits and lifestyle that promote obesity over the past several decades; the transition from “traditional” to modern “obesogenic” lifestyles is characterized by
Background: Migration from Thailand to Sweden has increased threefold over the last 10 years. Today Thailand is one of the most common countries of origin among immigrants in Sweden. Since the year 2000, new HIV cases are also more prevalent among Thai immigrants compared to other immigrant nationalities in Sweden. The purpose of this study was to investigate the association between knowledge and
Background: The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in the world. As one of the most important crop pests and virus vectors, B. tabaci causes substantial crop losses and poses a serious threat to global food security. Results: We report the 615-Mb high-quality genome sequence of B. tabaci Middle East-Asia Minor 1 (MEAM1), the first genome sequen
The chemosensory gene families of insects encode proteins that are crucial for hostlocation, mate finding, oviposition, and avoidance behaviors. The insect peripheralchemosensory system comprises odorant receptors (ORs), gustatory receptors (GRs),ionotropic receptors (IRs), odorant binding proteins (OBPs), chemosensory proteins(CSPs), and sensory neuron membrane proteins (SNMPs). These protein fam
Research in music, sound art and sound studies is not only a matter of listening and experiencing auditory phenomena. Neither is it limited to the study of scores, graphic notations or sonograms. With the still increasing expansion of practice-based research methods, many artists and scholars of music, sound art and sound studies now gain their knowledge through their creative practice, or through
Protoplanetary disks are the natural by-product of star formation and the sites of planet formation. Initially, they are composed of the gas and small solids they inherit from the molecular cloud they form in. The interactions between this material is complex and understanding their details is key for a complete picture of planet formation. The planet formation process begins with growth form abo
III-V semiconductor nanowires are high aspect ratio nanostructures with superior properties that can potentially enhance the functionality of next-generation opto-electronic devices. At present, the most reliable method for fabricating III-V semiconductor nanowires is the particle-assisted vapor-liquid-solid growth using a substrate-based growth process. However, a substrate-based process limits t
OBJECTIVES: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS).METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of t
