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Acquired ring chromosomes have been found in most types of human neoplasia, with a frequency approaching 10% in malignant mesenchymal tumours. In this study, the composition and dynamics of ring chromosomes were analysed in eight cases of acute myelogenous leukaemia, 17 solid tumours, and five cases with constitutional rings. Chromosomal banding and fluorescence in situ hybridisation were performe
Popular Abstract in Swedish Gastroesofageal refluxsjukdom är ett tillstånd som kännetecknas av att magsyra åker upp i matstrupen (reflux). Reflux är ett normalt fenomen som förekommer hos alla individer utan att orsaka symtom eller vävnadsskador. Hur detta normaltillstånd utvecklas till ett sjukdomstillstånd är ej helt klarlagt. Reflux förhindras normalt av en barriär vid övergången mellan matstruThere is a persisting controversy concerning the definition, etiology and pathogenesis of Barrett's esophagus. The dramatic and parallel increase in the incidence of esophageal and junctional adenocarcinoma over the past decades justifies an evaluation of the pathophysiology of premalignant metaplastic changes of the esophagus and the gastroesophageal junction. Patients were evaluated with upper G
Popular Abstract in Swedish Regimskiftet 1965-1966 i Indonesien åtföljdes av en massaker på kommunister och vänstersympatisörer, varvid uppskattningsvis 1/2 miljon människor fick sätta livet till. Ytterligare 100.000-tals personer internerades i över ett decennium, somliga så länge som 30 år utan att deras sak blev prövad i en rättegång. Andra blev summariskt avrättade. Så sent som på 1990 talet v
The European Union’s sugar policy is one of the most distorting policies within the common agricultural policy. It includes import control, production quota, and export refunds to support producer price within the EU at levels high above international prices. The main beneficiaries of the support system are the EU sugar industries and EU beet growers, but they are not the only producers benefiting
Carotenoids are one of the most widespread and important group of pigments in Nature and they can act as light-harvesting agents, photoprotectors and antioxidants. Mechanisms of their multiple functions are not fully understood mainly because their complicated photophysics involving ?dark? excited states. The central theme of this thesis is characterization of the lowest dark S1 state of carotenoi
This paper introduces the possibility of increasing the efficiency and minimizing the risk in functions marketing in the aircraft industry by focusing on better control of the logistic parameters. Functions marketing can be described as the marketing of a function rather than a product. The emphasis in this paper will be on the maintenance, i.e. repair and overhaul, of aircraft engines. Functions
Popular Abstract in Swedish Malmö erbjuder speciellt goda möjligheter till epidemiologiska studier, därför att all sjukhusbunden vård erbjuds av ett enda sjukhus som dessutom i stort sett endast täcker Malmös egna behov. Därtill kommer att nu avlidne professor Folke Linell redan under 1950-talet insåg den stora betydelsen för sjukvårdens kvalitet av en omfattande obduktionsverksamhet. Under periodIn the present thesis incidence, survival, mortality, cure and prognosis in invasive breast cancer in Malmö was studied over a 30 year period. Validated data from the Cancer Registry and the Cause of Death Registry were used. In the process of validation systematical biases were identified in both registers. The incidence increased over time and was strongly related to increases in diagnostic acti
Transforming growth factor-§ (TGF-§) is a potent, multifunctional growth factor affecting virtually all cell types, regulating critical physiological processes like immune response, wound healing, angiogenesis, and tumor development. A large number of studies in vitro have also implicated a critical role of TGF-§ in regulating hematopoiesis by inhibiting proliferation of hematopoietic stem cells (
Genetic and phenotypic variation in female response towards male mating attempts has been found in several laboratory studies, demonstrating sexually antagonistic co-evolution driven by mating costs on female fitness. Theoretical models suggest that the type and degree of genetic variation in female resistance could affect the evolutionary outcome of sexually antagonistic mating interactions, resu
We present progress in the development of artificial photosynthesis, as a means to harvesting and storage of solar energy. The plan is to compose molecular systems that combine known photochemistry with emerging functional model compounds. A photochemical device for solar energy conversion contains a photosensitizer, an electron acceptor system and a donor system that prevents charge recombination
Popular Abstract in Swedish I denna avhandling diskuteras förbättringar inom skallskadevården både vad gäller akut behandling och rehabilitering. Bakgrund Svåra traumatiska hjärnskador är en av de vanligaste orsakerna till död eller bestående invaliditet i västvärlden. Trafikskador dominerar, men fall (i samma plan eller från hög höjd), misshandel samt skottskador förekommer även. De två senare Mortality after severe head injury can be considerably reduce with a therapy using physiological principles for brain volume regulation and preserved microcirculation, with the main purpose of restricting the rise in ICP to reasonable levels simultaneously with preservation of adequate blood supply. This study shows that the ?Lund Concept? can reduce mortality in patients with severe traumatic bra
Popular Abstract in Swedish Alla människor har säkert någon gång i sitt liv haft en vanlig förkylning med snuva, och ökad slemproduktion som främsta symtom. På luftvägsslemhinnans yta möter kroppen omvärlden i form av inhalerade partiklar, bakterier och virus som fastnar i den tunna slemfilm som normalt täcker och skyddar det yttersta cellagret. Vid irritation av slemhinnan ses ofta en förhöjd sleMucins are essential components of the mucosal barrier. The complexity of the airway mucosal barrier is reflected in the lack of specific treatments to block mucin hypersecretion associated with several respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis. Currently, researchers in the mucin field are confronted with a growing number of mucin genes. In order to understand th
This thesis presents new results on fast correlation attacks on stream ciphers. In particular, fast correlation attacks on stream ciphers containing linear shift registers with an arbitrary number of taps, are considered. A general introduction to stream ciphers and correlation attacks is given. The introduction also presents standard properties of linear feedback shift registers and Boolean func
The present thesis concerns middle-aged women’s subjective well-being (SWB). The interest is focused on the importance of childhood factors, social circumstances, and personality for middle-aged women’s general SWB. Data were taken from the longitudinal research program Individual Development and Adaptation (IDA, Magnusson & Bergman, 2000) and concerned a sample of about 300 women. The main an
SETI, our hopes or fears of a future contact with ETI, is a modern expression of an unending human obsession with the rise and fall of civilizations. People across the globe from our earliest sources to our contemporary culture have tried to understand the beginning and end of history, the creation and the doom. Factor L of the Drake Equation could in other words be understood in a longer historic
Popular Abstract in Swedish I denna avhandling presenteras tre studier som fokuserar på human serviceorganisationer, klientarbete, arbetstillfredsställelse och arbetsmiljö. Det övergripande syftet med denna avhandling var att med särskilt fokus på grad av direkt klientarbete och tillfredsställelse i arbetet undersöka arbetssituationen i olika typer av human serviceorganisationer. I den första stuIn this thesis, three empirical studies investigating human service organizations pertaining to client work, work satisfaction, and the work environment are presented. The general aim of this thesis was to investigate working conditions in human service organizations with particular consideration and emphasis on the extent of human service workers´ client work and their perceived level of job sati
The activation of inflammatory cascades in the ischemic hemisphere impairs mechanisms of tissue reorganization with consequences for recovery of lost neurological function. Recruitment of T-cell populations to the post-ischemic brain occurs and represents a significant part of the inflammatory response. This study was conducted to investigate if treatment with levodopa, potentially acting as an im
Bone-marrow-derived progenitors must continually enter the thymus of an adult mouse to sustain T-cell homeostasis, yet only a few input cells per day are sufficient to support a yield of 5 × 10(7) immature T-cells per day and an eventual output of 1-2 × 10(6) mature cells per day. While substantial progress has been made to delineate the developmental pathway of T-cell lineage commitment, still li
Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health re
OBJECTIVES: To analyze whether there is an association between neighborhood deprivation and cervical cancer morbidity and mortality, beyond individual level characteristics. DESIGN: The entire Swedish population aged 25 to 74, a total of 1.9million women, were followed from January 1, 1990, until hospital admission due to cervical cancer during the study period, or the end of the study on Dece
