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Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix

The currently used 8% fragrance mix (FM I) does not identify all patients with a positive history of adverse reactions to fragrances. A new FM II with 6 frequently used chemicals was evaluated in 1701 consecutive patients patch tested in 6 dermatological centres in Europe. FM II was tested in 3 concentrations - 28% FM II contained 5% hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral((R))), 2% ci

The Dynamic Association Processes Leading from a Silica Precursor to a Mesoporous SBA-15 Material.

During the last two decades, the synthesis of silica with an ordered mesoporous structure has been thoroughly explored. The basis of the synthesis is to let silica monomers polymerize in the presence of an amphiphilic template component. In the first studies, cationic surfactants were used as structure inducer. Later it was shown that pluronic copolymers also could have the role. One advantage wit

Göra gatan. Om gränser och kryphål på Möllevången och i Kapstaden

Popular Abstract in Swedish Avhandlingen handlar om två städer - Malmö i Sverige och Kapstaden i Sydafrika - och om några speciella platser i dessa städer. Det handlar om stadsdelarna Möllevången och Woodstock strax utanför respektive städers centrum, och gatan Long Street som är beläget i själva Kapstadens hjärta. Det är platser som ingår i olika historiska och politiska sammanhang, där MöllevångThe dissertation is an ethnographic study focusing on two cities, Malmö in Sweden and Cape Town in South Africa. More specifically it focuses on three areas; the neighbourhoods Möllevången and Woodstock close to the respective city centres, and the street Long Street in the very heart of Cape Town central business district. These places belong to different historical and political contexts. Möllev

Sinners and citizens: Bestiality and homosexuality in Sweden

This study is based on an analysis of more than 2,300 court cases concerning acts of bestiality and same-sex sexuality in rural and urban Sweden 1880–1950. Other written sources are forensic psychi- atric statements, mental hospital records, material from the Swedish Sex Reform movement, news- papers and scientific journals, and minutes of the Swedish Parliament and its subcommittees. In coope

Sketching the Invisible : Patterns of Church and City in Theodoret of Cyrrhus' Philotheos Historia

Popular Abstract in Swedish Livet uppe på en pelare År 423 e.Kr. klättrade en man som närmade sig fyrtioårsåldern upp på en pelare, för att leva resten av sitt liv på dess topp; det skulle bli nästan fyrtio år till på knappt tjugo meters höjd. Han hette Symeon och skulle redan i sin samtid bli världsberömd för sin märkliga livsstil, som den första styliten, eller pelarhelgonet. I dagens krigsdrabThe fundamental question in this work concerns the ideal relation between asceticism and society in a 5th c. writing (C.E.), the Philotheos Historia (PH), written in elaborate Greek by the learned bishop of Cyrrhus, Theodoret. This collection of saints’ stories tells about the lives of a number of ascetics who lived in the Eastern part of the Roman Empire, many of them close to Antioch. As these n

Hieracium sect. Oreadea (Asteraceae) in Sweden - from a complete mess to a preliminary taxonomic classification

Among Swedish Hieracium sect. Oreadea (Fr.) Arv.-Touv., more than 100 taxa have been recognized by various experts but, except for a regional monograph from 1894 there are no thorough published revisions of the group and many of the names have never been validly published. At the same time, some of the oldest names have been variously applied to morphologically clearly different species. In the pr

Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors.

Reprogramming of somatic cells into pluripotency stem cell state have opened new opportunities in cell replacement therapy and disease modeling in a number of neurological disorders. It still remains unknown, however, to what degree the grafted human induced pluripotent stem cells (hiPSCs) differentiate into a functional neuronal phenotype and if they integrate into the host circuitry. Here we pre

The Compatibility of Limitation on Benefits Provisions in Tax Treaties with EC Law

Most bilateral tax treaties contain provisions with the objective of preventing different types of treaty abuse. Limitation on benefits clauses are an example of such provisions, and are generally found in United States tax treaties. These include various tests, which need to be fulfilled by a taxpayer wishing to enjoy the benefits of a tax treaty. Most of the United States tax treaties with EU Me

Properties of heavy rainfall in an East Asian monsoon catchment - Analysis of daily rain gauge data

The East Asian monsoon has a strong seasonal effect on the rainfall regime of Eastern China. In order to mitigate floods and conserve the water for use throughout the year, dams and other hydro-structures are built. The design of the structures requires knowledge of the rainfall characteristics that influence the inflow to them. In this thesis, the properties of heavy rainfall in a 73 000 km2 area

Endosomal escape of RNA therapeutics

RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key challenges with the development of new RNA-based t

Chem2Side : A Deep Learning Model with Ensemble Augmentation (Conventional + Pix2Pix) for COVID-19 Drug Side-Effects Prediction from Chemical Images

Drug side effects (DSEs) or adverse drug reactions (ADRs) are a major concern in the healthcare industry, accounting for a significant number of annual deaths in Europe alone. Identifying and predicting DSEs early in the drug development process is crucial to mitigate their impact on public health and reduce the time and costs associated with drug development. Objective: In this study, our primary

Modelling and analysis of multi-scale networks

The broad goal of this thesis is to develop a deeper mathematical understanding of the processes at work in the neuronal network of a brain by rigorously examining very fundamental elements of the processes involved. Paper I considers the flow of discrete signals on a graph and Paper II the complexity arising from the interplay of simple units. The concrete probabilistic investigations of such mod

Predictors of successful transition of adolescents and young adults living with HIV from pediatric to adult-oriented care in southern Ethiopia : a retrospective cohort study

Background: The introduction of highly active antiretroviral therapy has significantly improved the life expectancies of children and adolescents living with HIV, leading to an increased number transitioning to adult care. However, there has been a lack of studies in Ethiopia focusing on factors influencing the success of this transition. Therefore, this study aimed to determine predictors of a su

Acute tissue reactions, inner segment pathology, and effects of the antioxidant α1-microglobulin in an in vitro model of retinal detachment

The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment

Formation of planetary systems by pebble accretion and migration : Growth of gas giants

Giant planets migrate though the protoplanetary disc as they grow their solid core and attract their gaseous envelope. Previously, we have studied the growth and migration of an isolated planet in an evolving disc. Here, we generalise such models to include the mutual gravitational interaction between a high number of growing planetary bodies. We have investigated how the formation of planetary s

Ämnade för restaurangarbete? : Om politisk styrning och lågutbildade ungdomars väg fram till arbetsmarknadens tröskel

Den första januari 2012 sänkte den då sittande alliansregeringen momssatsen för restaurang- och cateringtjänster från 25 % till 12 %. Det övergripande målet med den lägre momssatsen är att stimulera efterfrågan på okvalificerad arbetskraft genom att skapa förutsättningar för lägre priser och därmed ökad efterfrågan på restaurangföretagens tjänster.Under tiden efter genomförandet av den sänkta momsA significant part of the labour market debate is devoted to issues concerning problematic youth. Expressions like “the lost generation” is coined to address the very core of the matter. It captures the difficulties for low-skilled young people to gain a sustainable work life in an education-oriented society. A strategy to increase employment opportunities specifically suited for the latter group

On Robust Distributed Control of Transportation Networks

With the ever-growing traffic demands, the transportation networks are getting more and more congested. While expanding these networks with more roads is both costly and in many cities not even feasible, the rapid development of new sensing and communication techniques has made it possible to perform control of transportation networks in real-time. With the right usage of such technologies, existi

Prevalence of Children Aged 6 to 23 Months Who Did Not Consume Animal Milk, Formula, or Solid or Semisolid Food During the Last 24 Hours Across Low- and Middle-Income Countries

IMPORTANCE: The introduction of solid or semisolid foods alongside breast milk plays a vital role in meeting nutritional requirements during early childhood, which is crucial for child growth and development. Understanding the prevalence of zero-food children (defined for research purposes as children aged 6 to 23 months who did not consume animal milk, formula, or solid or semisolid food during t

The analytical and clinical validity of AI algorithms to score TILs in TNBC : can we use different machine learning models interchangeably?

Background: Pathologist-read tumor-infiltrating lymphocytes (TILs) have showcased their predictive and prognostic potential for early and metastatic triple-negative breast cancer (TNBC) but it is still subject to variability. Artificial intelligence (AI) is a promising approach toward eliminating variability and objectively automating TILs assessment. However, demonstrating robust analytical and p

Analysis of self-monitoring of blood glucose metrics in gestational diabetes mellitus and their association with infants born large for gestational age : A historical observational cohort study of 879 pregnancies

Introduction: Self-monitoring of blood glucose (SMBG) is the standard of care for women with gestational diabetes mellitus (GDM). This study aimed to review SMBG profiles in women with GDM and to examine how glucose metrics derived from SMBG relate to fetal overgrowth and infants born large for gestational age (LGA, >90th percentile). Material and Methods: This was a single-center, historical, obs