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The only validated method to characterize the phenotype and to reach a definitive diagnosis of Malignant Hyperthermia Susceptibility (MHS; OMIM *145600), a pharmacogenetic disease linked to the Ryanodine 1 receptor gene (RYR1; OMIM *180901), is an invasive muscle contraction test requiring a muscle biopsy, according to the European (IVCT) protocol or to the North American (CHCT) protocol. The seri
Popular Abstract in Swedish Alzheimers sjukdom är den vanligaste orsaken till uppkomsten av demens. Detta tillstånd innebär att delar av hjärnan skrumpnar på ett karakteristiskt vis, när nervceller går under. Den drabbade brukar först märka svårigheter med korttidsminnet, för att senare drabbas av språksvårigheter, räknesvårigheter, svårigheter med rumslig uppfattning och svårigheter att veta hur Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. Efforts to develop effective treatments for humans have mostly been based on the assumption that a faulty homeostasis of beta amyloid (Aβ) is the triggering or the driving factor behind this co
Denna uppsats behandlar EU:s nya regler som förändrar kravet på prospekt - ett detaljerat informationsdokument som företag måste publicera när de erbju-der aktier till allmänheten eller noterar dem på en marknadsplats. Prospektet skyddar investerare genom att ge klar information om företaget, aktierna och riskerna, så att de kan fatta välgrundade beslut. Uppsatsen fokuserar på "tröskelvärdet&This essay discusses how the EU's new regulations change the requirement for prospectus - a detailed information document that companies must publish when offering shares to the public or listing them on a marketplace. The prospectus protects investors by providing clear information about the company, the shares, and the risks, enabling them to make well-informed investments. The essay focuses
I Sverige görs en åtskillnad mellan begränsat skattskyldiga skattesubjekt och obegränsat skattskyldiga skattesubjekt. Den person som är obegränsat skattskyldig är som huvudregel skattskyldig för alla sina inkomster, oavsett om inkomstens källa är i Sverige eller något annat land. Den person som är begränsat skattskyldig, däremot, är skattskyldig i Sverige enbart för vissa inkomster som har sin kälSweden distinguishes between limited taxable persons and fully taxable persons. A fully taxable person is, generally, taxable for all their worldwide income. A limited taxable person, on the other hand, is taxable in Sweden only for certain income derived from Sweden. A person that is not fully taxable, is a limited taxable person. Fully taxable persons are those who are domiciled in, stay regular
Vid utformningen av rätten att överklaga och prövningen i andra instans finns en mängd aspekter att ta hänsyn till. Dessa ställer på sätt och vis olika krav på prövningens utformning. Detta gäller såväl nationellt som internationellt. Vid utformningen av rätten att överklaga och prövningen i andra instans är det naturligt att landets konventionsåtaganden i form av art. 2 i sjunde tilläggsprotokollWhen forming the right to appeal and the trial in second instance there are a number of aspects to take into account and the different aspects sets, in certain ways, different demands on the form of the trial. This goes both nationally and internationally. When forming the right to appeal and the trial of second instance, it is natural to examine the countries obligations to Art. 2 of the Seventh
Tillgång till tillräckliga mängder vatten av god kvalitet är en väsentlig resurs för samhället. Det behövs för mänsklig konsumtion, för produktion i industrin, för fisket, etcetera. Det är därför mycket oroande att vattenkvaliteten i Europeiska unionen successivt försämras. Östersjön som är mycket påverkad av övergödning kan nämnas som ett exempel. Övergödning orsakas av utsläpp av näringsämnen iThe supply of good quality water is an essential resource for society. It is needed for human consumption, for production processes in the industry, for fishing, etcetera. The fact that the quality of waters within the European Union is continuously deteriorating is therefore of major concern. One example is the Baltic Sea, which is heavily affected by eutrophication. Eutrophication is caused b
Under Covid-19 pandemin har distansarbete varit en central del i strategin för att minska smittspridningen av viruset. Före pandemin arbetade endast 5 % av arbetstagarna inom EU på distans regelbundet. När pandemin bröt ut ökade andelen distansarbetare inom EU till nästan 40 %. Den snabba omställningen till distansarbete har aktualiserat flera arbetsrättsliga frågor. Syftet med denna uppsats är atDuring the Covid-19 pandemic, telework has been a central part of the strategy to reduce the spread of the virus. Before the pandemic, only 5% of EU workers worked remotely on a regular basis. When the pandemic broke out, the proportion of employees working remotely in the EU increased to almost 40%. The rapid transition to telework has raised several issues of labor law. The purpose of this thesi
Med anledning av kammarrättens dom i mål nr 4468-19 av den 20 novem-ber 2020 har tidpunkten för när en ansökan om upptagande till handel ska anses vara inlämnad på den reglerade marknaden Nasdaq Stockholm, och således när marknadsmissbruksförordnigen (”MAR”) blir tillämplig i en noteringsprocess, fastställts till tidpunkten för när Nasdaq Stockholms Admission Form B lämnas in. Detta innebär i prakAs a result of the Swedish Administrative Court of Appeal’s judgment in case no. 4468-19 of 20 November 2020, the time for when an application for admission to trading shall be considered to have been submitted to the regulated market Nasdaq Stockholm, and thus when the market abuse regu-lation (“MAR”) becomes applicable in a listing process, has been decided to the time of submission of Nasdaq St
After hatching, bird chicks are inevitably exposed to the thermal conditions of their environment. For the first stage of development chicks are not yet fully capable of maintaining a stable body temperature. During this time, their thermal environment can cause morphological and physiological priming. The plasticity of these responses and the extent to which they persist in the long-term is not w
Flera länder runt om i världen har valt att effektivisera sin brottsbekämpning genom att vidta åtgärder som öppnar upp möjligheter till förhandling mellan brottslingar och brottsbekämpande myndigheter. I Sverige kan rätten använda sig utav strafflindringande omständigheter vid påföljdsbedömningen, omständigheter som i dagligt tal kommit att kallas för billighetsskälen. En av de situationer som omfSeveral countries around the world have chosen to streamline their law enforcement by taking measures that enables opportunities for negotiation between criminals and law enforcement authorities. In Sweden, the court can make use of mitigating circumstances during the sentencing, circumstances that in daily speech have been called for the reasons of fairness. One of the situations covered by the g
The integration of small computer units in vehicles has made more complex in-vehicle functionality possible. To troubleshoot these more advanced functions, the diagnostic services need to read out more data from the integrated computer units, causing an increased network load. This has caused a demand on more efficient ways of performing vehicle diagnostics. One possible way to decrease the netwo
In recent years, there has been a surge in attention towards biodegradable polymer films, driven by the growing environmental awareness concerning the harmful effects of petroleumbased plastics. The maize protein zein, a by-product from wet milling processes, has shown potential to work as hydrophobic coating. The aim of this study has therefore been to find the most promising process conditions f
3D city models are valuable tools for visualization and analytical purposes in the urban environment. A popular format for city models is CityGML, an open data model that can be used for storage and exchange of 3D city models. However, using city models based on CityGML has appeared to be a challenge as there is a limited number of software applications that are able to read them. Complexity in Ci
Self-levelling flooring compounds (SLCs) are mainly used on concrete floors. Their purpose is to smooth the floors and make them horizontal. The fact that they are self-levelling means that they spread out like water over the floor before hardening to a horizontal layer. Some of them are also advertised as being self-desiccating. A quote from a big manufacturer on the Swedish market regarding thei
Background In a competitive market place a competing company has to focus on continuous improvements and effectiveness, something that can be achieved by investing in product resources which then generates a need of capital. The need of capital can be financed through direct financing or external financing such as leasing where the leasing company offers the customer capital support. Since 1999, A
Companies share their intellectual property with potential competitors in many different ways, including patent pooling. A patent pool is an agreement between two or more patent owners to license one or more of their patents to one another or to third parties. In Europe the Commission used the term patent pool as the bringing together of the patents of two companies, which makes it available for u
A patient who comes up against a bodily injury due to medical care, may be entitled to compensation - but the legal requirements in order to recieve compensation diversifies with the cause of damage. PSL comprises certain circumstances and identifies situations under which a patient may be entitled to insurance based indemnification. SKL is generally applicable on questions of pain-and-suffering a
Den tekniska utvecklingen har lett till att parts möjlighet att komma åt för tvisten relevant elektronisk lagrad information från motparten, blivit en allt större utmaning. För att komma sådan information förekommer det därför att parter ingår inspektionsavtal. Avtalen ger en eller båda avtalsparter rätt att genomsöka motpartens elektroniskt lagrade information, i syfte att iden-tifiera och/eller A party’s ability to access electronic information stored on an opponent’s hard disks – e.g. on a computer or on other electronic storage devices – has become increasingly challenging due to the technological development. In order to get hold of such information and to identify and/or recover deleted electronic information relevant to a dispute, parties sometime include an inspection clause in the
Private equity is a growing global phenomena and private equity companies have become a major force in many of Sweden’s industries. These companies own portfolio companies which together employs around 190 000 people and have an annual revenue of over 318 billion SEK. The purpose of this thesis was to describe and analyze the Swedish private equity industry and individual companies’ competitive st
Popular Abstract in Swedish HIV är en av de dödligaste farsoterna i världen och 30-40 miljoner människor beräknas ha dött AIDS. Genom att konstant förändra sig ligger viruset hela tiden ett steg före immunförsvaret, och immunförsvaret klarar därför inte av att bekämpa infektionen. HIV skiljer sig också från andra virus genom att det drabbar och långsamt utplånar immunförsvaret. Det gör att HIV kanThe two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. The V1-V3 region of the HIV-1 env gp120 is important for HIV-1 corecept
