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It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in rela
Popular Abstract in Swedish Bruket av slåtterängar som fodermarker har mycket gamla anor i Sverige. Slåtterängar karaktäriseras av att huvuddelen av de arter som växer här har inhemskt ursprung. De uppkom när människorna blev bofasta och klimatet så kallt att kreaturen behövde stallas under vintern (tidig Järnålder) och man därmed behövde vinterfoder till djuren. Idag är ängen en hotad biotop efteThe objectives of this thesis were to: 1) survey the vegetation in semi-natural meadows in south-central Sweden, 2) discern meadow vegetation changes in eight semi-permanent plots between studies performed in the 1960s and in 1990, 3) experimentally investigate the effects of variations in management intensity in one dry and one mesic meadow, 4) experimentally investigate the effects of different
Popular Abstract in Swedish Många av cellernas reglerings-, kommunikations- och interaktionssystem styrs av kolhydrater. Dessa kolhydrater sitter ofta bundna på proteiner och bildar då så kallade makromolekyler. En sådan grupp av makromolekyler kallas för glykosaminoglykaner. I de flesta medlemmar av denna grupp sitter långa kolhydratkedjor fast på proteinet via sockret xylos, även känt som björks
With the exponential growth of the World Wide Web, automated subject classification has become a major research issue. Organizing web pages into a hierarchical structure for subject browsing has been gaining more recognition as an important tool in information-seeking processes.The most frequent approach to automated classification is machine learning. It, however, requires training documents and
Background: Surgical removal of the stomach (gastrectomy, Gx) induces osteopenia. In this study we compared the osteopenic effect of Gx with that induced by calcium (Ca) deficiency. Methods: Young male rats were subjected to Gx and/or low Ca diet (-Ca). A group of Gx rats received standard diet + oral Ca supplementation (+ Ca). The rats were killed at various times after the operation/start of tre
Popular Abstract in Swedish Hjärtats skrifter är en undersökning av brevet som kommunikationsform under 1700-talet. Brevkulturen i 1700-talets Tyskland betraktas som ett av startskotten för vad som brukar kallas den moderna tiden. I denna studie granskas brevkulturens funktion och betydelse för det epistemiska skifte som äger rum under senare hälften av 1700-talet. Undersökningens utgångspunkt ärThis dissertation examines the correspondence of the 18th-century German authors Anna Louisa Karsch and Johann Wilhelm Ludwig Gleim. The main emphasis of the present study is to demonstrate how readings of Karsch's and Gleim's correspondence shed light on epistolary culture. Particular attention is paid to the notion of epistolary culture as a relatively unrestrained ?experimental setting? for bou
Popular Abstract in Swedish Denna studie avhandlar den internationellt välkända Brittisk-muslimska organisationen Islamic Foundation och dess nyförståelse och tillämpning av da‘wa, d.v.s. ’kallet’ eller ’inbjudan’ till islam. Da‘wa är en ungefärlig motsvarighet till de kristna missions- eller evangeliseringsbegreppen. Avhandlingen ägnar särskild uppmärksamhet åt organisationens förlagsverksamhet, This thesis deals with the conceptualisation of da‘wa, ‘the call to Islam’, of the British organisation the Islamic Foundation, and focuses its 25 years of publication of Islamic-English children’s literature. In order to analyse the implications of the new modalities of da‘wa in the late modern Muslim minority context, the present study applies a genealogical perspective. The study explores the
PURPOSE. To characterize the spectrum of mutations in the OPA1 gene in a large international panel of patients with autosomal dominant optic atrophy (adOA), to improve understanding of the range of functional deficits attributable to sequence variants in this gene, and to assess any genotype-phenotype correlations. METHODS. All 28 coding exons of OPA1, intron-exon splice sites, 273 bp 5' to exon 1
Popular Abstract in Swedish Denna studie handlar om sysselsättningsintegrationen av manliga och kvinnliga invandrare i Sverige mellan 1970 och 1995. Första kapitlet inleds med en översikt av teorier och tidigare studier om invandrares sysselsättning. Utifrån denna formuleras ett antal hypoteser. Det andra kapitlet ger en översikt av den svenska migrationshistorien, invandrarnas karaktäristika samt
PURPOSE: The dissertation addresses the choice of mode of transport, and the selection process, for local travel to regional rail service, with special emphasis on the significance of the bicycle. APPROACH TO THE PROBLEM AND METHODOLOGY: Choice of mode can be viewed as a 2-stage selection process in which different alternatives are rejected at different points in time. First there is a sorting amo
Popular Abstract in Swedish Variabilitet i ett läkemedels farmakokinetiska (hur ett läkemedel omsätts i kroppen) och farmakodynamiska (vilken effekt ett läkemedel har) egenskaper kan resultera i att olika individer som erhållit samma dos av ett läkemedel får olika effekter av läkemedel. Biverkningar eller utebliven effekt kan innebära allvarliga konsekvenser för den enskilda individen. VariabiliteVariability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. Lipophilic substances often have poor oral bioavailability and high inter- and intraindividual variability. High
Established histopathological criteria divide invasive breast carcinomas into defined groups. Ductal of no specific type and lobular are the two major subtypes accounting for around 75 and 15% of all cases, respectively. The remaining 10% include rarer types such as tubular, cribriform, mucinous, papillary, medullary, metaplastic, and apocrine breast carcinomas. Molecular profiling technologies, o
The extracellular matrix of the intervertebral disc structures contains many molecules also found in cartilage. The extremely polyanionic proteoglycans play a central role, particularly in the nucleus, by creating an osmotic environment leading to retention of water and ensuing resistance to deformation—important for the resilience of the tissue. Another major structural entity particularly impor
Background: The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated GAD (GAD-alum) to reverse recent-onset type 1 diabetes in patients 10 to 18 years of age. Methods: We randomly assigned 70 patients with type 1 diabetes who had fasting C-peptide levels above 0.1 nmol per liter (0.3
BACKGROUND: The incidence of distal radius fracture has increased substantially during the last 50 years according to several studies that estimated the overall incidence in various general populations. The incidence of fracture classified according to severity has not been well documented. The aim of this population-based study was to estimate the overall and type-specific incidence rates of dist
Popular Abstract in Swedish Inom svensk mjölkproduktion förekommer en hög frekvens av belastningsbesvär. Vid jämförelser mellan manliga och kvinnliga mjölkare har det visat sig vara stora skillnader avseende besvärsförekomst. Kvinnorna har rapporterat högre frekvens av problem i nästan alla kroppsdelar jämfört med männen. Dessutom har andelen hand- och handledsbesvär visat sig vara anmärkningsvärdThe aims of the thesis were to investigate the prevalence of the upper extremity musculoskeletal disorders in female milkers in relation to other occupational groups; to clarify the relationship between disorders and work environment, psychosocial and life style factors; to compare in a prospective study, pain, ache and discomfort reported by a questionnaire with clinical symptoms and sign; to exa
Bone and soft tissue tumors (BSTT) belong to a diverse group of solid tumors of mesenchymal origin, with a large number of histological types affecting individuals of all ages. The general aim of the present thesis (Articles I-V) was to investigate in detail the genetic aberrations in selected subtypes of benign and malignant BSTT. Aberrations identified by chromosome banding analysis were studied
The adsorption behavior of macromolecular emulsifiers is important in the understanding of their functionality. Understanding of the adsorption behavior can ultimately enable us to control emulsion properties. Adsorption during emulsification differs from many adsorption processes as the interface at which adsorption occurs is created in parallel with the adsorption. In this thesis two different m
Popular Abstract in Swedish Kemiska ämnen finns överallt i vårat samhälle och behövs för att vi ska kunna leva som vi gör. Produktionen av kemiska ämnen använder kemiska processer som ofta är dyra och förbättringar av driftsätt kan spara mycket pengar. För att förbättra en process krävs att experiment utförs som oftast är väldigt kostsamma och tidskrävande. Ett sätt för att minska antalet experimeChemical processes are usually expensive to run. To optimise a process, we need to know how the process behaves, and this is usually accomplished by studying the process experimentally. However, experiments are very expensive, particularly if an existing plant has to shut down normal operation to conduct an experiment. A better way is to build a model and simulate the process. In order to obtain t
Popular Abstract in Undetermined Syftet med avhandlingen är dels att undersöka författarbiografin som litterär text, dels att finna en rimlig ståndpunkt i den teoretiska debatt där biografins fiktionalitet har lyfts fram. I inledningen tar jag upp den teoretiska utveckling som rör detta metaperspektiv. För att ge en ram både åt dessa resonemang och mitt eget val av undersökningsobjekt, ger jag ockThe aim of the present thesis is twofold: to examine literary biography as literary text and, on the basis of my findings, to adopt a reasonable perspective on the theoretical debate about the fictionality of such biographies. In my introduction I trace the theoretical developments underlying this metaperspective and supply with an historical survey of literary biography as practised in Sweden. In
