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Widely varying published and presented analyses of the BEST TRIP randomized controlled trial of intracranial pressure (ICP) monitoring have suggested denying trial generalizability, questioning the need for ICP monitoring in severe traumatic brain injury (sTBI), re-assessing current clinical approaches to monitored ICP, and initiating a general ICP-monitoring moratorium. In response to this disson
The aim of this study was to develop a software program, called Landmarker, which would aid studies of complex anatomical morphometry by simplifying the manual identification of landmarks in 3D images. We also tested its precision on routine magnetic resonance imaging (MRI) scans. To understand human biological variation, there is a need to identify morphological characteristics from the exterior
Analysis of antibody repertoire development and specific antibody responses important for e.g. autoimmune conditions, allergy, and protection against disease is supported by high throughput sequencing and associated bioinformatics pipelines that describe the diversity of the encoded antibody variable domains. Proper assignment of sequences to germline genes are important for many such processes, f
Abstract in UndeterminedNanoindentation has recently gained attention as a characterization technique for mechanical properties of biological tissues, such as bone, on the sub-micron level. However, optimal methods to characterize viscoelastic properties of bones are yet to be established. This study aimed to compare the time-dependent viscoelastic properties of bone tissue obtained with different
The incidence of venous thromboembolism (VTE) is more than 1%omicron annually in the general population and increases further in cancer patients. The risk of VTE is higher in multiple myeloma (MM) patients who receive thalidomide or lenalidomide, especially in combination with dexamethasone or chemotherapy. Various VTE prophylaxis strategies, such as low-molecular-Weight heparin (LMWH), warfarin o
BACKGROUND: Amblyopia is the most common monocular visual impairment in Scandinavia. A visual screening programme for preschool children was introduced in Sweden in the 1970s to reduce the prevalence of amblyopia. The purpose of this study was to investigate the impact of this visual screening programme in adult men recruited to the armed forces in Sweden.METHODS: The prevalence of amblyopia was c
Objectives: To describe logarithm of the minimum angle of resolution (logMAR) best corrected visual acuity (BCVA) and intraocular pressure (IOP) after surgical management of late in-the-bag dislocation of the intraocular lens. Subjects/methods: In a single-centre prospective study, 165 consecutive cases having surgical correction for late in-the-bag-dislocation of intraocular lenses were analysed.
Background: Alcohol use disorder (AUD) is a classic multifactorial syndrome and it is critical to understand the diversity of the relevant risk factors and how they inter-relate over development. Method: We examined 21 risk factors for AUD in four developmental tiers reflecting (i) birth, (ii) childhood and early adolescence, (iii) late adolescence, and (iv) early adulthood in 47 414 Swedish men o
Importance: Longitudinal tau positron emission tomography (PET) is a relevant outcome in clinical trials evaluating disease-modifying therapies in Alzheimer disease (AD). A key unanswered question is whether the use of participant-specific (individualized) regions of interest (ROIs) is superior to conventional approaches where the same ROI (group-level) is used for each participant. Objective: To
The aluminium industry is facing a challenge in meeting the goal of halved greenhouse gas emissions by 2050, while the demand for aluminium is estimated to increase 2–3 times by the same year. Energy efficiency will play an important part in achieving the goal. The paper's aim was to investigate possible production-related energy efficiency measures in the aluminium industry. Mining of bauxite and
Aim: The risk for language disorder is high in children with all levels of hearing loss (HL). Early identification and intervention should be as important for children with mild HL as for those with more severe HL. Despite new-born hearing screening, a recent survey of speech language therapist services in southern Sweden indicates that children with mild and moderate HL are severely neglected whe
We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female
Background: Breast reconstruction after mastectomy helps women with breast cancer feel better about their bodies and lives. There is debate about the best time and type of reconstruction (immediate versus delayed, and using own tissue versus implants). Long-term studies are rare. Aim: This study looked at long-term results of different breast reconstruction methods and timings in Swedish women who
Introduction: Antibiotics for acute uncomplicated diverticulitis (AUD) have been questioned in several studies. Thus, it is of value to identify risk factors for recurrence and complications to identify the best strategy for treatment. The aim was to investigate risk factors for recurrence and complications within at least 1 year after hospitalization for AUD. Methods: This is a retrospective stud
Remote-sensing-based machine learning approaches for water quality parameters estimation, Secchi Disk Depth (SDD) and Turbidity, were developed for the Valle de Bravo reservoir in central Mexico. This waterbody is a multipurpose reservoir, which provides drinking water to the metropolitan area of Mexico City. To reveal the water quality status of inland waters in the last decade, evaluation of MER
Animal pollination is an important input to the global food system, affecting 2/3 of crops and worth more than $100 billion annually. Mounting evidence of pollinators’ importance, and of their decline worldwide, has prompted efforts to conserve and restore wild bees within agricultural regions. To date, however, research on the value of wild pollinators has focused largely on crop productivity per
Purpose: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite the best available treatment, prognosis remains poor. Current standard therapy consists of surgical removal of the tumor followed by radiotherapy and chemotherapy with the alkylating agent temozolomide (TMZ). Experimental studies suggest that antisecretory factor (AF), an endogenous protein with propose
Teaching Qualitative Methods with Computer-assisted Qualitative Data Analysis software Seminar dates, VT21: Friday, 21 May, 09:15-12:00 Wednesday, 2 June, 09:15-12:00 Literature* Brandão, Catarina, and António Pedro Costa. 2020. “Reflecting on CAQDAS and Ethics.” The Qualitative Report 25(13): 1-5. Evers, Jeanine C. 2018. “Current Issues in Qualitative Data Analysis Software (QDAS): A User and Dev
Carina Törn,1 David Hadley,2,3 Hye-Seung Lee,2 William Hagopian,4 Åke Lernmark,1 Olli Simell,5 Marian Rewers,6 Anette Ziegler,7 Desmond Schatz,8 Beena Akolkar,9 Suna Onengut-Gumuscu,10 Wei-Min Chen,10 Jorma Toppari,5 Juha Mykkänen,5 Jorma Ilonen,11,12 Stephen S. Rich,10 Jin-Xiong She,13 Andrea K. Steck,6 Jeffrey Krischer,2 and the TEDDY Study Group* Role of Type 1 Diabetes–Associated SNPs on Risk
https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_39_torn_diabetes_2014.pdf - 2026-06-24
Ett flertal studier har undersökt personlighet och kognitiv förmåga i förhållande till livsutfall. Det är däremot färre longitudinella studier som undersökt dessa samband, vilket medför oklarhet i hur mycket individuella skillnader kan förklara livsutfall. Syftet med denna studie var att använda senaste europeiska tvillingdata för att undersöka personlighet och kognitiv förmåga som prediktorer förNumerous studies have examined personality and cognitive ability in relation to life outcomes. However, longitudinal studies examining these relationships are relatively scarce, leaving the extent to which individual differences can account for life outcomes still unclear. The focus of this study was to use the latest European twin data to study personality and cognitive ability as predictors for
