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Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. During the drug development process, these proteins/peptides are affected by various environmental factors such as temp
In Sweden, the number of private extracts from the criminal records registry has increased more than five times since 2003. This is largely due to employers’ request for applicants to submit their criminal record if they want to be considered for a job. This is a phenomenon that is intrusive in the applicants’ integrity and it has become a society level problem. The aim of this paper is to describ
In this paper, we argue that the legitimation of killing in war is not simply formed by adherence to certain legal requirements that exist apart from and prior to war; instead, we suggest, the law of armed conflict in itself cannot but operate through admitting certain materials onto the battlefield as distinctively legal materials. Using the theory of legal materiality, we show that the military
BACKGROUND: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal declin
A detailed study has been made of the method for labeling plasmin (NOVO Indstri A/S Denmark) with 99mTc in order to prepare a radioactive indicator for early scintigraphic visualization of thrombi and tumors. The best method found for preparing 99mTc-plasmic involved the reduction of 2.5 ml 99mTc-pertechnetate solution with 0.5 ml of 4 mM SnCl2, 2 M NaCl and 70 mM HCl. This mixture was then added
Given the growing importance of bike-sharing systems nowadays, in this paper we suggest an alternative approach to mitigate the most crucial problem related to them: the imbalance of bicycles between zones owing to one-way trips. In particular, we focus on the emerging free-floating systems, where bikes can be delivered or picked-up almost everywhere in the network and not just at dedicated dockin
In this work we present an integrated system for whole chromosome analysis of single bacterium. Using whole genome barcoding techniques, which offer direct and rapid microscopic visualization of the entire genome in one field-of-view, we aim to rapidly identify individual bacterium. We are developing our device to achieve the crucial, and difficult process of isolating a bacterium, removing the DN
The last two decades have seen a significant increase in the number and quality of cross-national measures of institutions, which are also covering longer and longer time spans. However, despite the considerable progress that has been made, important measurement issues linger. This chapter argues that the key future challenge for the measurement of institutions is how to square objective or direct
Atmospheric new particle formation (NPF) is an important phenomenon in terms of global particle number concentrations. Here we investigated the frequency of NPF, formation rates of 10 nm particles, and growth rates in the size range of 10–25 nm using at least 1 year of aerosol number size-distribution observations at 36 different locations around the world. The majo
The aim of the MIRACHL project is the characterisation and monitoring of insituremediation of chlorinated hydrocarbon contamination using an interdisciplinary approach and geophysical methods, such as DCIP (direct current induced polarisation) to investigate the remediation process.To interpret these geophysical field IP data, lab investigations with different kinds of bacteria are necessary to as
The lidar technique is an efficient tool for remote monitoring of the distribution of a number of atmospheric species. We study measurements of sulphur dioxide emitted from the Italian volcano Mt. Etna. This study is focused on the treatment of data and on the procedure to evaluate range-resolved concentrations. In order to make an in-depth analysis, the lidar system was prepared to store measurem
Writers typically spend a certain proportion of time looking back over the text that they have written. This is likely to serve a number of different functions, which are currently poorly understood. In this article, we present two systems, ScriptLog+ TimeLine and EyeWrite, that adopt different and complementary approaches to exploring this activity by collecting and analyzing combined eye movemen
PURPOSE: The formation and spreading of market-, management- and individual-rights discourses into society, as well as the movement of consumerism, have paved the way for a transformation of the linguistic usage. The transformation suggests that the view of the care seeker has shifted from a waiting patient, via a consumer to a customer creating value. Another example of the process is that the fo
Summary: Polymethylmethacrylate, as a widely used material for vertebroplasty, has several drawbacks such as heat development and high allergenic potential. In order to avoid these drawbacks ceramic cement materials have been developed. The purpose of this study was to evaluate a new biointegrative material for vertebroplasty in osteoporotic vertebral fractures regarding pain relief, safety aspect
Computed tomography (CT) is often a justified diagnostic tool, but is also associated with high exposure of the patients. Due to the rapid increase in the number of CT units and thus the availability of CT examinations in Russia, there is a growing need for optimisation within this field. In order to develop proper optimisation procedures for CT, the two regions St. Petersburg and Belgorod of Russ
“Can an engineer, using a current simulation modelling programs, produce evacuation flow rates of a live emergency evacuation a priori to the analyses of the evacuation?” The above question is explored with reference to previous pre-evacuation modelling attempts and a new series of “small-scale” underground train evacuation experiments conducted under the METRO research project. METRO is concerne
In this paper, we consider positioning with observed-time-difference-of-arrival (OTDOA) for a device deployed in long-term-evolution (LTE) based narrow-band Internet-of-things (NB-IoT) systems. We propose an iterative expectation- maximization based successive interference cancellation (EM-SIC) algorithm to jointly consider estimations of residual frequency- offset (FO), fading-channel taps and ti
The aim of this study is to explore the possibility of identifying speaker stance in discourse, provide an analytical resource for it and an evaluation of the level of agreement across speakers in the area of stance-taking in discourse. We explore to what extent language users agree about what kind of stances are expressed in natural language use or whether their interpretations diverge. In order
