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The epidermal growth factor receptor (EGFR) is a receptor involved in cell proliferation. It is frequently overregulated in cancer cells, making it an attractive target for cancer therapeutics. One possible pharmaceutical is protease-X; a protein involved in the cleavage of the EGFR and thus, a way to regulate the receptor’s activity and lead the cancer cells to apoptosis. The aim of this thesis h
The purpose of this work is the development, identification and validation of a model for the simulation of a thermomechanical multistage production process chain for sheet steels. The process of interest consists of forming (in particular deep-drawing) followed by cutting and heat treatment. For the forming and cutting stages, the complete model is based in particular on a model for thermoelastic
Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. Although academia and industry have been researching ATAs exte
Many product development projects nowadays use computer-aided engineering systems in the analysis of product proposals. It is therefore important to appropriately integrate the analyses activities in the product development process. One important aspect of this integration is how to handle the initiation of the task: identifying the need, planning the task and its monitoring, and communicating it
In modern chemical process industry, process state transitions, orgrade changes, are common operations. For example, for a papermachine, a common operation is to change the surface weight of theproduced paper. In this case it is of importance that the transitionto the new grade is done fast, but without a breakdown asa result. This paper addresses this problem by combining optimizationtechniques a
Biogas, a mixture of methane and carbon dioxide, is produced by microorganisms upon degradation of organic matter in an anaerobic environment. It has been realised that by utilising anaerobic processes the organic pollutants in wastewater and organic solid waste from anthropogenic sources can be converted into a renewable source of energy. However, to fulfil the potential of anaerobic digestion in
The paper describes a simple and efficient control loop decoupler for TITO (two inputs, two outputs) control systems. The inverted decoupling approach is used, and the feedforward filters are just static gains. The feedforward gains are determined in two ways, from a static analysis and from optimization. By investigating several cases found in literature, it is found that the two sets of feedforw
Lignin, the most abundant aromatic biopolymer on Earth, is often considered a biorefinery by-product, despite its potential to be valorized into high-added-value chemicals and fuels. In this work, an integrated superstructure-based optimization model was set up and optimized using mixed-integer non-linear programming for the conversion of technical lignin to three main biobased products: aromatic
New food products are constantly put on the market. Today the focus often lies in creating nutritional and sustainable products to reduce the environmental impact of the product in question. One example of this is the approval of the yellow mealworm, Tenebrio Molitor, as a novel food in the European union. To efficiently include the protein fraction of the yellow mealworm into food formulations, k
In process industry many control loops are far from optimally tuned. In this master's thesis a tool for rapid process identification and control design has been developed. The tool, which is implemented in Matlab 5.3, identifies a process model out of the step response of the real process. A PI or PID controller can then be designed and evaluated. The tool contains three different automatic de
A novel isolation and purification method was developed for producing 1,3-propanediol with high purity and high yield from the mixture containing 1,3-propanediol, 1,2-propanediol, glycerol, and glucose. The developed method, which consisted of phase separation and chromatography, was found to be a simple and efficient procedure for the isolation and purification of 1,3-propanediol from the other c
