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Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r

https://www.energy.lth.se/research/energy-storage-conversion - 2026-07-05

Originalidad y periferia. Existe una forma de "originalidad" que nada tiene que ver con la forma de interpretar los hechos culturales. Según esta manera de ver la cultura, lo que hace a ésta original es su carácter único, su particularidad antropológica e histórica. Del mismo modo que cada ser vivo es portador de un banco genético único, es cada forma de la cultura portadora de una herencia cult

A series of homoleptic bis(tridentate) [Ru-(L)(2)](2+) (1, 3) and heteroleptic [Ru(L)(dqp)](2+) complexes (2, 4) [L = dqxp (1, 2) or dNinp (3, 4); dqxp = 2,6-di(quinoxalin-5-yl)pyridine, dNinp = 2,6-di(N-7-azaindol-1-yl)pyridine, dqp = 2,6-di(quinolin-8-yl)pyridine) was prepared and in the case of 2 and 4 structurally characterized. The presence of dqxp and dNinp in 1-4 result in anodically shifte

Syftet med denna studie är att undersöka urvalet av litterära texter i spanska som akademiskt ämne i Sverige under perioden 2000-2017 med fokus på genus. Hypotesen är att universitetet i sin egenskap av litteraturförmedlande institution gynnar konsekrerade verk av manliga författare, och att studenterna i hög grad låter sig orienteras av lärarnas urval. En undersökning av litteraturlistor från spaEl objetivo de este estudio es examinar la selección literaria de español como asignatura académica en Suecia del periodo 2000-2017 con enfoque en la cuestión de género. La hipótesis es que la universidad, en su calidad de institución transmisora, privilegia la literatura consagrada, de autor masculino, y que los estudiantes en alto grado se dejan orientar por la selección de los docentes. El estu

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Sagem Défense et Sécurité (now Safran Electronics & Defense), a French space and defense company of the SAFRAN group, is working on the next generation of Unmanned Aerial System (UAS). This UAS features a fully automatic Unmanned Aerial Vehicle (UAV) equipped with a state-of-the-art navigation system. This navigation system relies mainly on a high-accuracy Inertial Measurement Unit (IMU) coupl

This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed by their identification and quantification using mass spe

Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro. We have examined whether such mAbs have detrimental effects on pre-existing cartilage. Bovine cartilage explants were cultured over 21 days in the presence of two arthritogenic mAbs to

A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient

Radiocarbon analysis of the carbonaceous aerosol allows an apportionment of fossil and non-fossil sources of airborne particulate matter (PM). A chemical separation of total carbon (TC) into its subfractions organic carbon (OC) and elemental carbon (EC) refines this powerful technique, as OC and EC originate from different sources and undergo different processes in the atmosphere. Although C-14 an

The heterodinuclear mixed-valence complex [FeMn(ICIMP)(OAc)(2)Cl] (1) {H2ICIMP = 2-(N-carboxylmethyl)-[N-(N-methylimidazolyl-2-methyl)aminomethyl]-[6-(N-isopropylmethyl)-[N-(N-methylimidazolyl-2-methyl)]aminomethyl-4-methylphenol], an unsymmetrical N4O2 donor ligand} has been synthesized and fully characterized by several spectroscopic techniques as well as by X-ray crystallography. The crystal st

Background: Malaria kills almost 1 million people every year, but the mechanisms behind protective immunity against the disease are still largely unknown. Methodology/Principal Findings: In this study, surface plasmon resonance technology was used to evaluate the affinity (measured as kd) of naturally acquired antibodies to the Plasmodium falciparum antigens MSP2 and AMA1. Antibodies in serum samp