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Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Tidplan-DESS-Rigg_250422.xlsx C:\Hardeberga Energiteknik AB\Kunder\Ecergy\P2308 LTH HP-rigg\04 Planering\Tidplan-DESS-Rigg_250422.xlsx DESS-Rigg - Återställning 2024-2025 Anders Dahl 2025-04-22 Projektresurser LTH Jens, Christer, Anders O Anm: "Driftsättning-kall" pausas för Montage kassetter samt tryckkärl (tunga lyft) Ecergy Anders Dahl Afry Tara Sabzevari Leverantörer Bricon, APQ-el, Rörläggare
https://www.energy.lth.se/sv/sites/energy.lth.se.sv/files/2025-05/Tidplan_DESS_2024-2025_250422.pdf - 2026-07-09
CFEWP47 CFE Working paper series No. 47 Effective Judicial Protection of Individuals A duty for the Court of Justice or the National Courts? Cecilia Sjöstrand CFE Working papers are available at the website of the Centre for European Studies www.cfe.lu.se 2 Centre for European Studies at Lund University: Box 201: Phone +46 (0)46-222 88 19 SE-221 00 LUND Fax: +46 (0)46-222 32 11 Sweden E-mail: cfe@
https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfewp47.pdf - 2026-07-09
Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with
Tumor-specific monoclonal antibodies (mAbs) offer several modes of tumor cell killing, from direct cytotoxic activity to indirect mechanisms employing the host immune system, particularly its innate branch. The latter effector functions seem to dominate among clinically approved anti-cancer mAbs and major efforts are being undertaken by both academia and the pharmaceutical industry with the aim to
A new type of continuous, supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing specific fractionation and separation of human peripheral blood lymphocytes in a chromatographic format. The affinity adsorbent was used to design a novel cell separation strategy, which was based on the interaction of protein A from Staphylococcus aureus with cells bearing IgG antibodies on
In this paper, the authors show that liquid-liquid partition chromatography in an aqueous two-phase system offers unique possibilities of comparing the overall surface properties of intact antibodies in solution before and after binding of antigen. The authors demonstrate that the surface properties of antigen-antibody complexes are dependent on the variable regions of the antibodies, the nature o
Microsoft Word - Litteraturlista_LIVR26_HT2018 LIVR26 LKM: Spansk litteratur fram till och med guldåldern Fastställd av styrelsen för Sektion 3 den 24 maj 2018 att gälla från HT18 Obligatorisk litteratur/Literatura obligatoria Anónimo. (1992-) Lazarillo de Tormes. Madrid: Cátedra. http://www.cervantesvirtual.com/obra-visor-din/la-vida-de-lazarillo-de-tormes-y-de- sus-fortunas-y-adversidades--0/htm
https://www.sol.lu.se/media/utbildning/dokument/kurser/LIVR26/20192/LIVR26_HT19.pdf - 2026-07-07
