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Background: A panel of four kallikrein markers (total, free, and intact prostate-specific antigen [PSA] and human kallikrein-related peptidase 2 [hK2]) improves predictive accuracy for Gleason score ≥7 (high-grade) prostate cancer among men biopsied for elevated PSA. A four-kallikrein panel model was originally developed and validated by the Dutch center of the European Randomized Study of Screeni
The slippery slope argument is often used in (bio)ethical debates. It is an intriguing argument: it confronts us with fears, gut feelings, and fundamental values; it invites us to think about the future, and it forces us not only to look at a technology or policy in isolation but at the whole picture. Rhetorically it is attractive with its often vivid images and sweeping statements, sometimes deri
We consider the over-fitting problem for multinomial probabilistic Latent Semantic Analysis (pLSA) in collaborative filtering, using a regularization approach. For big data applications, the computational complexity is at a premium and we, therefore, consider a maximum a posteriori approach based on conjugate priors that ensure that complexity of each step remains the same as compared to the un-re
The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelat
Jordbruksmodernisering har dramatiskt ökat tillgången till mat på global nivå, men till ett högt pris för miljön. Idag efterlyser många ett ’paradigmskifte’ i jordbruket, även flera stora mainstream-institutioner. Med ett skifte till vad? Under senare år har det synts en ökande tilltro till agroekologi, ett alternativ som syftar till att förstå och bedriva jordbruk som komplexa agroekosystem. FrånAgricultural modernization has massively increased global food supply, but at a high environmental cost. Today many are calling for an agricultural ‘paradigm shift’, including several mainstream institutions. But to what? In recent years, agroecology has gained credence as an alternative approach that seeks to understand and manage farms as complex agroecosystems. From a development perspective, i
Artistic research is a comparatively new academic field, displaying multiple epistemological and methodological approaches. Through a concrete exemplification, this article studies how knowledge formation and learning may take place in artistic fields by way of intermedially borrowed concepts. The prominent use of the concept of ’musicality’ as a prestige word in the field of spoken theatre is inv
The strength and tensor structure of the Higgs boson's interactions are investigated using an effective Lagrangian, which introduces additional CP-even and CP-odd interactions that lead to changes in the kinematic properties of the Higgs boson and associated jet spectra with respect to the Standard Model. The parameters of the effective Lagrangian are probed using a fit to five differential cross
Two smartphone applications were developed with the aim of harvesting insights of vulnerable road user accidents. The apps require a backend database with software tools for generating and managing questionnaires, etc. Such a system was developed using a MySQL database where a user-friendly platform has been developed in CakePHP. The backend system has been successfully developed and been used to
Resandet med tåg har ökat stadigt i Sverige de senaste 30 åren. Takten har varit cirka två-tre procent per år, och vi nu har mer än dubbelt så många resenärer. Med ökat fokus på klimatfrågan stiger resandet nu ännu snabbare. Ett problem som drabbar både resenärer och företag i Sverige är tågförseningar. Ett sätt att beskriva dessa är den andel av alla tåg som kommer fram mer än fem minuter för senTravel by train has increased steadily in Sweden the last 30 years. The pace has been about two to three percent per year, and we now have twice as many passengers. With growing awareness of the changing climate, the pace is increasing further. A problem that affects both passengers and businesses in Sweden is train delays. One way to describe these is as the share of trains that arrive less than
In the last 15 years we have seen, as a response to power and thermal limits for current chip technologies, an explosion in the use of multiple and even many computer cores on a single chip. But now, to further improve performance and energy efficiency, when there are potentially hundreds of computing cores on a chip, we see a need for a specialization of individual cores and the development of he
Positioning is an essential feature in Narrow-Band Internet-of-Things (NB-IoT) systems. Observed Time Difference of Arrival is one of the supported positioning techniques for NB-IoT. It utilizes the downlink NB positioning reference signal (NPRS) generated based on a length-31 Gold sequence. Although a Gold sequence has good auto-correlation and cross-correlation properties, the correlation proper
We consider time-of-arrival (ToA) estimation for a device working in narrowband Internet-of-Things (NB-IoT) systems. Due to a limited 180 kHz bandwidth, the time-domain auto-correlation function (ACF) of transmitted NB positioning reference signal (NPRS) has a wide main-lobe. Without considering that, the performance of ToA estimation can be degraded for two reasons. Firstly, the NPRS correspondin
We propose an improvement over a modulus zero-forcing (MZF) detector proposed earlier in [1] for multi-input multi-output (MIMO) detection, namely, the joint MZF (JMZF) detector. The MZF detector provides better detection-performance than a traditional ZF detector through preserving controllable interferences, which are mitigated later by nonlinear modulus arithmetic operation. However, the MZF de
In massive MIMO systems the uplink pilot signalstransmitted by a terminal define the channel seen by the basestation. This gives the terminal some degree of freedom selectingan uplink pilot transmission strategy. In this paper, we investigatethe benefit of different pilot transmission strategies when increasingthe number of antennas in the terminal. Building on previouswork on a simulation framewo
The Theory of Characteristic Modes has been shown capable of facilitating the development of many high-quality antennas through providing the characteristic modes (CMs) inherent to a structure. The CMs will change if the structure is altered; this property has been used to adapt terminal antennas, enabling good MIMO performance in compact structures. Previously these designs focused on altering th
Many application areas for embedded systems, such as DSP, media coding, and image processing, are based on stream processing. Stream programs in these areas are often naturally described as graphs, where nodes are computational kernels that send data over the edges. This structure also exhibits large amounts of concurrency, because the kernels can execute independently as long as there are data to
Fifth-generation (5G) new radio (NR) deployments are being rolled out in both the C–band (3.3 - 5.0 GHz) and millimeter-wave (mmWave) band (24.5 - 29.5 GHz). For outdoor scenarios, the C–band is expected to provide wide area coverage and throughput uniformity, whereas the mmWave band is expected to provide ultra-high throughput to dedicated areas within the C-band coverage. Due to the differences
Application of the faster than Nyquist signaling method to the upcoming fifth generation wireless system
Methods for energy and bandwidth efficient coded digital communication, including pulse design, non-orthogonal signaling methods, and the faster than Nyquist signaling method.
A survey of faster than Nyquist results over the last 15 years, with and extension of earlier binary modulation/convolutional coding results to four-level modulation.
