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In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17β-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the

Denna uppsats undersöker hur fem icke-statliga organisationer (NGO) framställer händelserna kring Sea-Watch 3-fallet sommaren 2019. Räddningsfartyget hölls kvar till havs i över två veckor efter att ha undsatt migranter utanför Libyens kust, utan att någon stat erbjöd en säker hamn. Studien utgår från en kombination av två teoretiska ramverk: normmodellen och liminalitet. Normmodellen används för This thesis examines how five non govermental organisations (NGO) represent the events surrounding the Sea-Watch 3 case in the summer of 2019. The rescue vessel remained at sea for over two weeks after saving migrants off the coast of Libya, without any state offering a safe port of disembarkation. The study draws on a combination of two theoretical frameworks, the norm model and liminality. The n

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2019_1.pdf - 2026-06-22

Purpose: This study investigates how the Chinese government generates authority during a crisis through discursive practices expressed in social media. Design/methodology/approach: Using the theoretical framework of authority and the method of genre analysis, this study examined the top 100 forwarded posts on Weibo about a highprofile murder to determine the mechanisms involved in generating autho

Investeringssparkonto (ISK) infördes den 1 januari 2012 som en schablonbeskattad sparform för fysiska personer. I stället för att beskattas för faktiska utdelningar och kapitalvinster erlägger innehavaren en årlig skatt beroende på ett kapitalunderlag som approximativt motsvarar portföljens förväntade avkastning. Systemet är kon-struerat med utgångspunkt i en inhemsk skattemässig kontext. När inneThe Swedish Investment Savings Account (ISK) is a lump-sum taxed savings vehicle introduced on 1 January 2012. Instead of being taxed on actual dividends and capital gains, the account holder pays an annual tax calculated on a deemed capital base approximating the portfolio’s expected return. When foreign listed shares are held in an ISK, a complication arises: the source state’s right to withhold

Social cohesion has been defined in multiple ways by the literature, depending on the disciplinary perspective and context. Existing definitions commonly emphasize trust, solidarity, shared values, and social networks, treating social cohesion as a relatively stable condition. However, there remains a limited understanding of how social cohesion is experienced and constructed, specifically within

I takt med att avgasutsläpp från förbränningsmotorer minskar blir bidraget från icke-avgasemissioner till luftföroreningar allt mer betydande. En av de viktigaste källorna till dessa emissioner är slitage från bromsar. Trots att störst mängd bromsslitage kommer från tunga fordon är detta ett relativt outforskat ämne. Denna studie syftar därför till att fylla kunskapsluckorna som finns gällande bro

Aim of the review: To provide an overview of studies that have published dataregarding region and population size, procedure location, team composition, inclusionand exclusion criteria, outcome parameters, and cost–benefit analyses onextracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.Data sources: A structured systematic literature search of articles published pr

Taboo obsessions are ego-dystonic, recurrent, and intrusive thoughts involving aggressive, sexual and/or religious themes, which are common in individuals with obsessive-compulsive disorder (OCD). These symptoms are often challenging to treat with traditional, exposure-based approaches. Our research group has developed and successfully piloted an Internet-delivered intervention based on the cognit

Confidential computing allows processing sensitive workloads in securely isolated spaces. Following earlier adop- tion of process-based approaches to isolation, vendors are now enabling hardware and firmware support for virtualization-based confidential computing on several server platforms. Due to variations in the technology stack, threat model, implemen-tation and functionality, the available s

The Swedish Hernia Register (SHR) is a national quality register with more than 350,000 prospectively registered groin hernia repairs. Studies from the SHR have addressed important and clinically relevant issues within the field of laparoscopic groin hernia surgery and the aim of this paper is to present five of the most innovative patient-oriented publications including analysis of laparoscopic h

Regionaliseringsprosesser og politisk regionalisme har over lengre tid blitt sentrale temaer i akademiske debatter om nasjonalstaters re-skalering og den såkalte misnøyens geografi. Lignende dynamikker er også til stede i Norge, hvor regionreformen som ble gjennomført i 2020 møtte motstand langs sentrum-periferi-linjer. Slike fenomener stiller spørsmål om hvordan ulike aktører bidrar til regionersRegionalisation processes and regionalist contestation have been the subjects of long-standing debates on state rescaling and political geographies of discontent. Similar dynamics are also present in Norway, where a recent regional reform has faced opposition along centre-periphery lines. These phenomena raise questions about how different actors discursively enact the institutionalisation and/or

Changes in environmental temperature during development can affect growth, metabolism and temperature tolerance of the offspring. We know little about whether such changes remain to adulthood, which is important to understand the links between climate change, development and fitness. We investigated whether phenotypic consequences of the thermal environment in early life remained in adulthood in t

Recent years’ publications have shown how valuable information can be in the integrity management of civil structures. Monitoring systems increase the knowledge about the structural state, improving the prioritization of the interventions, and the selection of optimal maintenance strategy and thereby allowing for budget optimization and risk minimization. This paper investigates the effect of mult

In this thesis, I discuss the nature of responsibility and punishment. The main aim is to present a philosophical account of responsibility and punishment that is open to insights from other disciplines such as evolutionary biology, cognitive science, politics, cultural studies, and so forth.In the first section, which consists of three papers, I examine the relationship between responsibility, li

Hållbarhet och hållbar mobilitet har blivit viktiga mål i national politik och policy. Cykling har dock inte kunnat dra nytta av detta. Om man betraktar cyklingens betydelse under de senaste decennierna, och dess förväntade betydelse i framtiden, finns emellertid få anledningar till optimism, åtminstone inte på nationell och övergripande nivå; cykeln befinner sig fortfarande i skuggan av bilen. DeSustainability and sustainable mobility have become important political goals and have left their mark as important discourses in national policies and programs. Against expectations, cycling has barely benefited from this. Looking back over the shoulder at the significance of cycling over the last few decades and looking forward to suggested implications in the future give no reason for joy, at l

Adaptive radiation is a major source of biodiversity but the way in which known components of ecological opportunity, ecological differentiation, and reproductive isolation underpin such biodiversity patterns remains elusive. Much is known about the evolution of ecological differentiation and reproductive isolation during single speciation events, but exactly how those processes scale up to comple