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Astrocytes are one of the major cell types in the central nervous system and are indispensable for brain development and function. The human brain and human astrocytes have unique structures and functions that are not present in other animal species. Studies of fundamental astrocyte biology in humans and their role in neurological disease have been hindered by shortage of native human astrocytes f
The argument running through Sevilla-Buitrago’s analysis is that spatial planning as a form of expertise cannot be untethered from capitalist urbanization, but that planning also must be related to urban commons, conceptualized as the actually existing self-management of resources in opposition to capital. The book’s four case studies are used all in an argument contending that planning must ‘neutThe argument running through Sevilla-Buitrago’s analysis is that spatial planning as a form of expertise cannot be untethered from capitalist urbanization, but that planning also must be related to urban commons, conceptualized as the actually existing self-management of resources in opposition to capital. The book’s four case studies are used all in an argument contending that planning must ‘neut
Since 2003, the United Nations international human rights framework has moved notably toward increased international human rights recognition for sexual and gender minorities. Most recently, 2016 saw the adoption of an Independent Expert on violence and discrimination based on sexual orientation and gender identity. Motivated by the nevertheless continued refusal by predominantly African and Middl
A polyethylene terephthalate (PET)-degrading bacterium identified as Stenotrophomonas maltophilia PRS8 was isolated from the soil of a landfill. The degradation of the PET bottle flakes and the PET prepared as a powder were assessed using live cells, an extracellular medium, or a purified cutinase-like enzyme. These treated polymers were analyzed using Fourier transform infrared spectroscopy
Unga vuxna nämns ofta som bland de mest ekonomiskt utsatta grupperna och Sverige karakteriseras ofta som ett av de länder i EU som har de mest skuldsatta hushållen. Även om hushållens skuldsättning främst är kopplad till bostadslån, har även andra former av kreditanvändning blivit allt vanligare. Mot bakgrund av en ökande tillgången till lättillgängliga konsumentkrediter, en tuff bostadsmarknad meYoung adults are often mentioned as among the most financially vulnerable groups, and Sweden is often characterized as being one of the countries in the EU with the most indebted households. While this houshold indebtedness mainly is linked to home loans, also other forms of credit usage have become increasingly common. Given the increasing access to readily availabe consumer credits, a difficult
Background: The aim of this study was to clarify the possible causal associations between education phenotypes and non-fatal suicide attempts. In particular, we evaluated the roles of academic achievement (school grades), cognitive performance (IQ), and educational attainment (education level). Methods: Based on longitudinal Swedish registry data, we included 2,335,763 individuals (48.7% female) w
Background: Adolescent pregnancy and associated neonatal mortality are major global health challenges. In low-income settings where 90% of the 21 million global adolescent pregnancies occur, half are unintended and a fifth experience unsafe abortion. In Kenya, Uganda, and Tanzania, the survival patterns of neonates born to adolescents are unclear.Objectives: To assess survival patterns among neona
BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual
We develop a cognitive evaluation schema for analysing the diversity and nuances of visuospatial complexity and multimodal interactions encountered in naturalistic everyday driving conditions. The proposed schema is based on a finegrained empirical analysis of real-world everyday driving situations involving stakeholders such as drivers, pedestrians, cyclists. Our method involves a semantic analys
Introduction: Digital options for osteoarthritis (OA) treatment are increasingly available with high patient satisfaction and acceptability. Little is, however, known about physical therapists’ (PT) perception of this treatment modality. Objective: To investigate PT’s experience of delivering digital treatment for hip and knee OA using a smart-phone application. Method: Nine PTs (mean age 36 years
Background: Compared to negative experiences and ill health, little attention has been paidto positive experiences connected to being transgender and gender diverse (TGD).Aim: The aim of the current study was to explore TGD people’s positive experiences in depth.Methods: In total, 33 TGD people were interviewed. Transcripts were analyzed using reflexivethematic analysis.Results: Results show that
OBJECTIVES: Early diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) MRI parameters, including cerebral blood volume (CBV), cerebra
Despite advancements in multiple myeloma treatment, prognostic variability persists. We investigated the impact of income and education on treatment and survival in a country with publicly funded healthcare. We analysed data from the Swedish Myeloma Registry (2008–2021) linked to national registers. Cox models assessed survival, adjusting for demographics and comorbidities. Treatment patterns were
The Swedish digital games industry portrays itself as inclusive and egalitarian, yet structural inequalities persist, particularly for women. Despite progress in gender equality in Sweden, the industry remains male-dominated, with women comprising only 24% of the workforce in 2023. Female game developers often face exclusion, sexism, and limited career opportunities, being relegated to less presti
Abstract:Background:The need for vascular procedures for certain disease-specific causes is a majorissue for health care today. This thesis will focus on endovascular treatmentfor PAD and malfunctioning haemodialysis access. Although many other vasculardiseases and anatomic regions sometimes need to be managed with endovascularprocedures, PAD and haemodialysis access together account for a signifi
Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. Proliferation of HSCs is linked to decreased reconstitution potential, and a precise regulation of actively dividing HSCs is thus essential to ensure long-term functionality. This regulation becomes important in the transplantation setting where HSCs unde
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM
De första levande organismerna uppstod på jorden när den funnits i 1,5 miljarder år. Under de följande tre miljarder åren bildades livet på jorden, och existerade i harmoni, med gravitation, kosmisk-strålning, elektriska och magnetiska fält och dess cyklisk-hemlighetsfulla variationer medan exponeringen från den naturlga mikrovågstrålningen var endast i storleksordningen 210-15 W/kg. Det var i deOur team of the clinical researchers in Lund, Sweden, found that electromagnetic radiation, such as those used in mobile communications, even at shallow power values, cause users’ blood albumin to leak through the blood-brain barrier “BBB” into the brain tissue. The BBB is supposed to protect the brain against unwanted and toxic molecules potentially present in the blood, to transfer to the brain
Introduction: Pre-analytical sample handling might affect the results of Alzheimer's disease blood-based biomarkers. We empirically tested variations of common blood collection and handling procedures. Methods: We created sample sets that address the effect of blood collection tube type, and of ethylene diamine tetraacetic acid plasma delayed centrifugation, centrifugation temperature, aliquot vol
Wanting to help others and benefit society in one’s future career are examples of communal career goals. Raising these goals in youth should increase interest in HEED-occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender-skewed and face labor shortage. Research has yet to find ways to increase communal career goals. In this study, we test the novel Wanting to help others and benefit society in one’s future career are examples of communal career goals. Raising these goals in youth should increaseinterest in HEED-occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender-skewed and face labor shortage.Research has yet to find ways to increase communal career goals. In this study, we test the novel hy
