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BACKGROUND: The urokinase receptor (uPAR/CD87) is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA) and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex forme

Europe Indo-Pacific Institute of South Asian Studies National University of Singapore 29 Heng Mui Keng Terrace #08-06 (Block B) Singapore 119620 Tel (65) 6516 4239 Fax (65) 6776 7505 URL www.isas.nus.edu.sg SOUTH ASIA DISCUSSION PAPERS EUROPE IN THE INDO-PACIFIC: MOVING FROM PERIPHERY TO THE CENTRE? 2 SOUTH ASIA DISCUSSION PAPERS Europe in the Indo-Pacific: Moving from Periphery to the Centre? Ins

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/europe_indo-pacific_.pdf - 2026-07-25

The current juvenile delinquency has been a debated subject for a long time, for instance among politicians, scientists, media and the police. Some think it has increased dramatically during the last years, while some claim the opposite. During the fall of 2017 the government commissioned an investigation regarding a proposal of removing the juvenile discount for young offenders. The treatment ide

Sverige tillåter för närvarande inte anonyma vittnesmål. Ämnet har trots det varit uppe för diskussion i Sverige sedan 90-talet. Med anledning av den ökade gängkriminaliteten samt vittnens otillräckliga skydd ses anonyma vittnen som en alternativ lösning på problemet. Syftet med uppsatsen är att utreda huruvida ett system med anonyma vittnen hade fungerat i svensk rätt eller inte. Undersökningen Anonymous witnesses are not allowed in the Swedish legal system, although the subject has been debated in Sweden for decades. Due to increased organized crime and inadequate witness protection, anonymous witnesses is discussed as a solution to the problem. The purpose of this essay is to straighten out if a system of anonymous witnesses would be possible in the Swedish legal system. This is done

Rhesus Rhadinovirus (RRV) is currently the closest known, fully sequenced homolog of human Kaposi's sarcoma-associated herpesvirus (KSHV). Both these viruses encode complement inhibitors: KSHV-complement control protein (KCP) and RRV-complement control protein (RCP). Previously we characterized in detail the functional properties of KCP as complement inhibitor. Herein, we performed comparative ana

BackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

A business becoming more common in todays labour market is the one of consultants. The idea of consultants is that they come into a company as experts in order to solve a problem and when the problem is solved and the contract has expired they move on to another costumer/client. These are usually shorter persiods of time, which means that consultants are constantly looking for new assignments. The

Popular Abstract in Swedish Hematopoes är den process under vilken alla röda och vita blodceller i kroppen bildas. Denna process sker kontinuerligt i benmärgen och förser kroppen med blodceller under hela livet. I benmärgen finns en viss typ av omogna celler sk stamceller som alla olika typer av blodceller bildas ifrån. Genom att stamceller gradvis mognar så bildas mogna blodceller som transporterThe Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The ojective of this thesis was to investigate the role of WT1 during human hematopoiesis and leukemia. To ga

Popular Abstract in Swedish Anorexia nervosa är en sjukdom som i över 100 år förbryllat den medicinska vetenskapen. Det är en sjukdom med okänd orsak, oförutsägbart förlopp och där ingen enskild behandlingsmetod kunnat hävda sig som den mest effektiva. Den självförvållade svält, som är det främsta symtomet i sjukdomen, har i alla tider fascinerat mänskligheten. Trots att det är en relativt sällsynThis dissertation presents a study of 26 adolescent anorexia nervosa patients and their families regarding family function and treatment. Family function was studied at the start of treatment and at two-year follow-up. In a Nordic study, 49 families were studied at the start of treatment, and different sub-groups of families were examined. The 26 patients took part in a randomised controlled study

Popular Abstract in Swedish När vi blir infekterade av virus eller bakterier (patogener) hjälper olika delar av vårt immunförsvar till att försvara oss från dem. Vår hud, slemhinnor, magsyra och vissa immunceller hjälper till att ospecifikt och snabbt hindra patogenerna från att angripa oss och ofta räcker detta för att infektionen skall klaras av. Men det finns en del till av vårt immunförsvar soT lymohocytes (T cells) and B lymphocytes (B cells) are important effector cells of the adaptive immune system. In response to infections, B cells are activated and produce antibodies against specific antigens. There are two types of T cells, cytotoxic T cells that kill cells infected with bacteria or viruses, and helper T (Th) cells that help B cells produce antibodies by secreting cytokines as w

We present high-precision relative radial velocities of the very low mass star VB 10 that were obtained over a time span of 0.61 years as part of an ongoing search for planets around stars at the end of the main sequence. The radial velocities were measured from high-resolution near-infrared spectra obtained using the CRIRES instrument on the Very Large Telescope with an ammonia gas cell. The typi

This paper has two purposes. The first, empirical purpose is to estimate and evaluate the effects of aggregate income, institutional and socio-demographic factors on health care expenditures in the OECD countries. The second purpose is methodological, and comprises assessment of temporal instability, the choice of functional form, and misspecification of the estimated relationships. Data compiled