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Intensification of arable crop production degrades soil health and production potential through loss of soil organic carbon. This, potentially, reduces agriculture's resilience to climate change and thus food security. Furthermore, the expected increase in frequency of adverse and extreme weather events due to climate change are likely to affect crop yields differently, depending on when in the gr

BACKGROUND AND OBJECTIVES: Degarelix is a gonadotropin-releasing hormone antagonist registered for the treatment of advanced hormone-dependent prostate cancer. Treatment causing androgen deprivation is associated with QT prolongation and this study investigated whether degarelix at supratherapeutic concentrations has an intrinsic effect per se on cardiac repolarisation and the QT interval.METHODS:

In the last decades spatiotemporal manifestations of shopping are changed radically in conjunction with proliferation of car usage, internationalization of retail, and establishment of out-of-town malls. The social, cultural, and economic backgrounds of this axis alteration and its implication to the city life have been discussed thoroughly. However, the main empirical focus laid mostly on the mai

During the preclinical period of insulin-dependent diabetes mellitus (IDDM), progression to clinical IDDM is characterized by declining β-cell function. Although the presence of insulin autoantibodies (IAA) improves the ability of islet cell antibodies (ICA) to predict subsequent clinical IDDM, few studies have examined the risk of developing IDDM in subjects positive for IAA but negative for both

Plasma levels of islet cell cytoplasmic and cytotoxic antibodies were determined in 10 children with insulin-dependent diabetes mellitus (IDDM) treated with plasmapheresis shortly after diagnosis, and in 9 children with IDDM treated by conventional means alone. Islet cell cytoplasmic antibody (ICA) titers were determined by indirect immunofluorescence using unfixed sections of human pancreas, and

Non-competitive N-methyl-D-aspartate receptor antagonists mimic schizophrenia symptoms and produce immediate and persistent antidepressant effects. We investigated the effects of ketamine and phencyclidine (PCP) on thalamo-cortical network activity in awake, freely-moving male Wistar rats to gain new insight into the neuronal populations and brain circuits involved in the effects of NMDA-R antagon

Purpose: The purpose of this paper is to elaborate on how perspectives and assumptions embedded in the complexity paradigm contribute to make logistics management research better aligned with real-life logistics. This is necessary, due to increasing supply chain complexity caused by an increasing request for sustainable development (SD). Design/methodology/approach: The research is exploratory and

Sarcomeric mitochondrial creatine kinase (Mi(b)-CK) of chicken was expressed in Escherichia coli as a soluble enzyme by using an inducible phage-T7 promoter. Up to one third of the protein in E. coli extracts consisted of soluble recombinant Mi(b)-CK in an enzymically active form. Approx. 20 mg of nearly-homogenous Mi(b)-CK was isolated in a two-step isolation procedure starting with 1 litre of is

Aim: The aim of this pilot study was to explore the Fear of Birth Scale in a mixed sample of women of childbearing age, by investigating the levels of childbirth fear and the content of women's thoughts when completing the scale. Methods: A cross-sectional mixed method study of 179 women who completed a short questionnaire and a think aloud interview. Results: The mean score of the Fear of Birth S

Arctic homeotherms counter challenges at high latitudes using a combination of seasonal adjustments in pelage/plumage, fat deposition and intricate thermoregulatory adaptations. However, there are still gaps in our understanding of their thermal responses to cold, particularly in Arctic birds. Here, we have studied the potential use of local heterothermy (i.e. tissue cooling that can contribute to

A socially mixed population is a politically stated ambition in Stockholm, the capital of Sweden. By providing a variety of tenure alternatives – i.e. rental and ownership housing – throughout all neighborhoods it is presumed this objective could be at least partially fulfilled. Since current tenure proportions display a weak balance in many neighborhoods it could consequently be assumed that gove

Inverse modelling is a useful tool for retrieving CH4 fluxes; however, evaluation of the applied chemical transport model is an important step before using the inverted emissions. For inversions using column data one concern is how well the model represents stratospheric and tropospheric CH4 when assimilating total column measurements. In this study atmospheric CH4 from three inverse models is com

The treatment of Parkinson's disease (PD) has for over 50 years relied on dopaminergic therapies that are highly effective especially in the early years of the condition, but ultimately are limited by the development of side effects that relate to the nonphysiological stimulation of dopamine receptors including in nonstriatal areas. Targeted regenerative therapies designed to restore specifically

Public procurement represents a very large share of most economies worldwide. Besides its direct purchasing power, public procurement has an enormous potential to become one of the most important mission-oriented policy instruments in the context of the Sustainable Development Goals. The paper argues that the key to achieve more innovations when pursuing public procurement is to describe problems

The compelling images and promises attached to autonomous drive vehicles can easily create an impression that one can speak of a radical distinction between a self-driving future and a manual-driving present. Yet today’s drivers can already refer to their everyday driving as being experienced as though on ‘auto-pilot’, in which they are able to drive their cars while lost in things such as daydrea

Popular Abstract in Swedish Om vi använder allt tillgängligt fossilt bränsle kommer detta leda till att havsnivån ökar med mer än 50 m, enligt nya rön [1]. Även om detta hot ligger långt in i framtiden, finns ett flertal akuta problem kopplade till den globala uppvärminingen. FNs klimatpanel (IPCC) förutspår i sin senaste rapport en stor ökning av torka, skogsbränder, kraftiga orkaner, svält och mTo enable the transition to a green, bio-based economy, an extensive enzymatic toolbox competitive to traditional chemical procedures is needed. One strong area for enzymes is carbohydrate chemistry, due to the over-functionalized nature of carbohydrates, difficult to handle in traditional chemistry. Glycosylation can be catalyzed by four main classes of enzymes, glycosyltransferases, glycoside ph

Popular Abstract in Swedish Prostanoider, en samlingsbeteckning för prostaglandiner och tromboxaner, tillverkas av de flesta av kroppens olika celltyper och fungerar som en slags hormoner i många olika organsystem i människor och djur. Prostanoiderna bildas alla från prostaglandin H2 som i sin tur tillverkas av enzymet cyklooxygenas (COX) från fettsyran arachidonsyra. Prostanoiderna är alltså fettProstanoids are ubiquitously distributed lipid signaling molecules derived from arachidonic acid, that exhibit numerous and diverse biological effects in a variety of physiological and pathophysiological conditions. The cell surface receptors for the prostanoids belong to the family of G protein-coupled receptors. In this thesis, the author describes the cloning and structural characterization of

This paper examines the value to Swedish citizens of reducing the risk for salmonella bacteria in chicken filet. The contingent valuation (CV) study is based on the results of a postal questionnaire that was distributed to 2 000 randomly selected Swedish citizens aged 18-74. The valuation format used is a stated preference double bounded dichotomous choice. We employ the non-parametric Turnbull Lo

Popular Abstract in Swedish I många tekniska applikationer vill man på något sätt överföra elektrisk energi till mekanisk energi eller tvärtom. Det kan till exempel handla om att med hjälp av en elektrisk signal generera eller mäta rörelse. Så kallade elektroaktiva material har den speciella egenskapen att överföringen mellan elektrisk och mekanisk energi sker direkt. I ett piezoelektriskt materiaThe electroactive polymer materials considered in this work react to electric stimuli by producing deformations. In some cases, the electrically induced deformations are moderate, while in other cases they can be very large and the specimen is stretched to more than twice its original length. The latter response is seen in so called dielectric elastomer actuators (DEA). The possibility of very lar