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Background: Extracellular vesicles (EV) are nano-sized membranous structures released from most cells. They have the capacity to carry bioactive molecules and gene expression signals between cells, thus mediating intercellular communication. It is believed that EV confer protection after ischemic preconditioning (IPC). We hypothesize that myocardial ischemic preconditioning will lead to rapid alte

Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and hereditary breast cancer using five microsatellite markers spanning the chromosomal region 13q12-q13 which harbours the BRCA2 breast cancer susceptibility gene, and using one other marker located within the RBI tumour-suppressor gene at 13q14. LOH at the BRCA2 region was found in 34% and at RBI in 27% of th

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance that primarily affects women of childbearing age. The underlying pathophysiology of POTS is not fully understood, but it has been suggested that autoimmunity may play a role. The aim of this study was to compare concentrations of autoantibodies to cardiovascular G protein-coupled receptors between

We used diblock poly(acrylic acid)-b-poly(2-dimethylamino ethyl methacrylate) (PAA-b-PDMAEMA) polyampholytes to prepare core-shell complexes with ionic surfactants. The dispersions have been characterized by means of small-angle X-ray scattering (SAXS), cryogenic transmission electron microscopy (Cryo-TEM), dynamic light-scattering, and zeta potential methods. Using cationic or anionic surfactants

Loss of appetite and negative energy balance are common features of endotoxemia in all animals and are thought to have protective roles by reducing nutrient availability to host and pathogen metabolism. Accordingly, fasting and caloric restriction have well-established anti-inflammatory properties. However, in response to reduced nutrient availability at the cellular and organ levels, negative ene

We conducted a phase I-IIa, randomized, monocentric, double-blind, placebo-controlled clinical trial to evaluate the safety and impact of the combination treatment of Itolizumab and insulin on preserving beta cell function in adults with recent-onset type 1 diabetes. Twelve patients were randomly assigned to three treatment groups, each receiving a different Itolizumab dose (0.4/0.8/1.6 mg/kg body

Obsessive-compulsive disorder (OCD) is a treatable condition that often requires specialist care, particularly when comorbid with autism spectrum disorder (ASD). However, specialist clinics are few and typically located in large medical centers. To increase availability of evidence-based treatment for OCD in individuals with ASD, we adapted an internet-delivered cognitive behavior therapy (ICBT) p

PURPOSE: Epinephrine is used in local anesthetics to induce vasoconstriction and thus reduce bleeding and prolong the anesthetic effect. Finding the optimal delay between the administration of the anesthetic and skin incision to ensure vasoconstriction and minimize bleeding is important and has recently become the subject of debate. This is the first study to assess blood perfusion and oxygen satu

Since the 1970s critical marketing scholars have called for systemic change to overcome the ethical problems generated by consumption, such as unsustainable resource use, industry-induced climate change, and social inequities. Mainstream marketing research has instead problematised the individual consumer and sought ways to diminish the so-called gap between ethics and consumption. The current con

Introduction: Emergent mental illness during adolescence affects daily functioning, causing disruption to daily activities, routines, and patterns. Multiple inter-related personal, social and environmental determinants influence the onset, nature and subsequent course of those difficulties. Research suggests a bi-directional relationship exists between mental health and activity choices. Activity-

OBJECTIVE: To investigate whether maternal paracetamol use in early pregnancy is associated with cerebral palsy (CP) in offspring.STUDY DESIGN: We conducted a registry and biobank-based case-control study with mother-child pairs. We identified CP cases (n=322) born between 1995-2014 from a nationwide CP-registry. Randomly selected controls (n=343) and extra preterm controls (n=258) were obtained f

The presence of distant protoplanets may explain the observed gaps in the dust emission of protoplanetary disks. Here, we derive a novel analytical model to describe the temporal decay of the pebble flux through a protoplanetary disk as the result of radial drift. This has allowed us to investigate the growth and migration of distant protoplanets throughout the lifespan of the disk. We find that M

Objective: We investigated differences in somatosensory profiles (SSPs) assessed by quantitative sensory testing in children and adolescents with cerebral palsy (CCP) with and without chronic pain and compared these differences to those in a group of typically developed children and adolescents (TDC) with and without chronic pain. Method: All included subjects were consecutively recruited from and

Sustainable products have arrived on the market and faced competition with traditional products with one extra challenge: they normally tend to be more expensive than traditional ones. Customers are yet to pay more for these products as they are alerted for environmental impacts. However, the gap between knowledge and action is being decreased slowly. One of the factors for this sluggish behavior

Under appropriate conditions, neural tissues transplanted into the adult mammalian brain can survive, integrate, and function so as to influence the behavior of the host, opening the prospect of repairing neuronal damage, and alleviating symptoms associated with neuronal injury or neurodegenerative disease. Alternative mechanisms of action have been postulated: nonspecific effects of surgery; neur

Många sjukdomar som inte beror på virus eller bakterier kopplas ofta till genetik. Vår förståelse kring hur gener påverkar vår hälsa har ökat dramatiskt med molekylärbiologins framfart. Sedan 1930-talet har det utvecklats nya tekniker för att tyda gener och dess DNA. Länge var gener ett ganska abstrakt koncept, man visste att det fanns något som fördes vidare genom generationerna men inte exakt vaTo find true genetic associations in complex diseases, such as allergic rhinitis and chronic rhinosinusitis, is a difficult task. Both are polygenetic diseases where it is believed that genetic variation in several genes make up their phenotypes. In addition, the environment of the affected individuals also play an important role, further obscuring eventual associations. Today most genetic associa