Sökresultat

Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h

Fatal accidents in UK’s manufacturing sector are expected to remain the same or increase in coming years. This paper has tried to combat this issue by adapting and further developing a previously defined Safety Framework for the Paint Sector, to evaluate the safety performance of a metal manufacturing facility. To achieve this, the original Safety Framework was updated to align with the current Br

Everyday driving relies on cognitive functions such as visual search, change detection and predictive attention for maintaining a high-level mental model of the world. Such functions are especially constrained by limited cognitive resources under complex conditions. Understanding the manner in which environmental complexity influences cognitive driving performance is key to improving road safety a

Within Relevance Theory, it has been suggested that extended metaphors might be processed differently relative to single metaphoric uses. While single metaphors are hypothesized to be understood via the creation of an ad hoc concept, extended metaphors have been claimed to require a switch to a secondary processing mode, which gives greater prominence to the literal meaning. Initial experimental e

Background Functional Somatic Disorders (FSD) and Internalizing Psychiatric Disorders (IPD) are frequently comorbid and likely share familial/genetic risk factors. Methods We performed a Common Factor Multivariate Analysis of 2 FSDs, Fibromyalgia (FM) and Irritable Bowel Syndrome (IBS), and two IPDs, Major Depression (MD) and Anxiety Disorders (AD), in five kinds of Swedish female-female relative

Introduction: The healthcare sector is globally experiencing increasing demands and workplace interventions on an organisational level is sought to create healthy workplaces. The aim of this study was to provide an overview of Nordic research on the work environment and health of healthcare professionals, with a focus on identifying organisational-level risk and health-promoting factors. Methods:

Light to the Nations is a work created by Yael Bartana which combines different media such as sculpture, VR, and video animation, as well as a learning center.It is a proposal about the attempts, dystopic and utopic, to save humanity in the face of a global catastrophe, whether man-made or caused by nature, which would extinguish any possibility of life on Earth. The work is influenced by post-apo

BACKGROUND & AIMS: Emerging evidence implicates the importance of perinatal and early-life exposures in colorectal cancer (CRC) development. However, it remains unclear whether being breastfed in infancy is associated with CRC risk in adult life, particularly early adulthood.METHODS: We prospectively investigated the association between history of being breastfed and risk of CRC and its precur

Youth anxiety disorders are common and heterogeneous. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered tool designed to assess overall anxiety severity, independent of specific symptoms. The thresholds on PARS for the reliable change index (RCI), the minimal clinically important difference (MCID), treatment response, and full and partial remission remain unclear. Using the Cli

Introduction: The risk of celiac disease (CD) is high in children with type 1 diabetes (T1D). While some studies have linked CD in children with T1D to impaired growth and poorer glycaemic control, results have been inconsistent. Further, no study has examined the relevance of whether the diagnosis of CD is established before, in conjunction with, or after T1D. We aimed to examine whether CD influ

Context. Aims. The goal of this paper is to demonstrate the outstanding quality of the second data release of the Gaia mission and its power for constraining many different aspects of the dynamics of the satellites of the Milky Way. We focus here on determining the proper motions of 75 Galactic globular clusters, nine dwarf spheroidal galaxies, one ultra-faint system, and the Large and Small Mage

BACKGROUND Orthostatic hypotension (OH), defined as a sustained drop in systolic or diastolic blood pressure upon standing, is known to negatively affect survival in the general population. However, its impact on outcomes in patients with advanced coronary artery disease remains unclear. The aim of this study was to assess the prevalence and prognostic value of OH in patients undergoing isolated c

The purpose of this thesis is to investigate if there are any differences regarding syntactic complexity in written language between persons with (phonologically based) reading and writing difficulties and a control group. Earlier research has pointed to such a difference, indicating that texts written by subjects with reading and writing difficulties display a lower grade of syntactic complexity

Background: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. Purpose: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD pati

Objective: The study aimed to examine the vocal behavior and self-assessed vocal health in women with varying everyday vocal load and functional voice problems, including patients with functional dysphonia, in three conditions: work, leisure, and a vocal loading task (VLT). Study Design: This is a longitudinal controlled, clinical trial. Methods: Fifty (n = 50) female subjects were tracked during

Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro. We evaluated the role of human SULT1A1 in AA bioactivation in vivo after treatment of transgenic mice carrying a fu