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The effects of phlorizin on several parameters of β-cell function were studied with microdissected islets of obese-hyperglycemic mice. At a concentration of 10 mM, phlorizin significantly depressed insulin release, glucose transport, glucose oxidation, and the level of fructose 1,6-diphosphate, when tested in the presence of 10 mM glucose. Whereas 1 mM phlorizin inhibited glucose transport by abou
Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a
Violence is central to social life, especially for people at the margins of urban society. This article examines ethnographic data collected in Oslo among individuals who are involved in street life and crime. We propose the following typology for understanding violence in this population: respect-based violence, business violence, drunken violence, and family violence. We argue that from an emic
Temporal and spatial variability of soil water content on mainly two different scales is visualized by means of correlation analyses. The soil water data were collected at seven sites for a period of about ten years. The spatial variability of soil water in the unsaturated zone is illustrated and discussed from the aspects of interdepth, intersite and temporal changes respectively. The results in
The aim of the present paper is to explore the interrelated and complex relationships between religionsvetenskap (Religious Studies), religionskunskap (Religious Education) and religionsdidaktik (Religion and Education). After briefly outlining the concurrent developments of Religious Studies as a university discipline and Religion and Eudcation as a non-confessional school subject, both of which
This study examines the views of stakeholders involved in house renovations regarding the one-stop-shop business concept innovation, and assesses their level of preparedness to adopt such a concept in order to enter the promising market of detached house renovations. The investigation is based on 25 interviews with construction SMEs owners, real estate agents and loan consultants, and on a concept
Many retail chains believe that the personal service encounter is the solution to declining sales figures. Via a large-scale study of Swedish fashion consumers, we demonstrate, that this may not necessarily be the case. We argue that retailers can potentially save money and convert more customers by providing a more automated journey, which includes self-service technologies, for some customers, a
The aim of this work was to compare the production of carotenes and ergosterol by red yeasts grown on pine lignocellulose substrates. The yeast strains Rhodotorula aurantiaca and Sporobolomyces shibatanus were grown on the liquid fraction of steam pretreated pine (210 °C, catalyst SO2). Biomass production on a pine hydrolysate was lower than on glucose. The highest content of carotenoids and ergos
This paper presents the moisture dependency of moisture transport and moisture fixation in mortars with OPC, slag and silica fume. Water vapor desorption isotherms were measured with gravimetric methods and the moisture dependency of moisture transport was investigated with cup-tests. The results show an ongoing evolution of water vapor desorption isotherms from eight months to four years. The evo
During the past decade, there has been accumulating evidence of the involvement of passive and active cell death mechanisms in both the clinical setting and in experimental models of traumatic brain injury (TBI). Traditionally, research for a treatment of TBI consists of strategies to prevent cell death using acute pharmacological therapy. However, to date, encouraging experimental work has not be
This paper contains a study of the extent to which aggregate losses due to severe wind storms can be explained by wind measurements. The analysis is based on 12 years of data for a region, Ska § ne, in southern Sweden. A previous investigation indicated that wind measurements from six recording stations in Ska § ne was insufficient to obtain accurate prediction. The present study instead uses geos
In this article, we introduce and demonstrate the concept-metaphor of broken data. In doing so, we advance critical discussions of digital data by accounting for how data might be in processes of decay, making, repair, re-making and growth, which are inextricable from the ongoing forms of creativity that stem from everyday contingencies and improvisatory human activity. We build and demonstrate ou
Many firms manage the innovation process by using metrics. Yet, whether measurement supports or hinders innovation continues to be a topic of debate. To shed new light on this debate, this paper presents a conceptual framework of how measurement engages attention in firms. We draw on attention based theory and conceptualize innovation measurement as an attention-focusing device. We identify two id
The article tells the story of the rise and fall of the organic store Yggdrasill in Iceland. That story features humble founders, caring customers, dedicated staff, as well as anonymous investment funds, and it describes the conversion of organics from a niche market to mainstream consumption. Through an ethnographic account of everyday life at the organic store, the article analyzes how intimacy
In psychology as elsewhere, the main statistical inference strategy to establish empirical effects is null-hypothesis significance testing (NHST). The recent failure to replicate allegedly well-established NHST-results, however, implies that such results lack sufficient statistical power, and thus feature unacceptably high error-rates. Using data-simulation to estimate the error-rates of NHST-resu
Although the relationship between trade and the success of international sanctions has been a topic of many debates in political economy over the past 30 years, the effect of sanctions on foreign direct investment (FDI) is still largely unexplored. Using the data for 184 countries from 1970 to 2010 and bias-corrected estimators, this study tests the effect of sanction imposition on foreign investm
