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Human proinsulin (HPI) and C-peptide (HCP) were visualized by specific monoclonal antibodies (Mab's) in the conventional indirect immunofluorescent assay for ICA (islet cell cytoplasmic antibodies) on frozen sections of human pancreas. Two different Mab's, GS-9A8 (anti-HPI, mouse IgG1) and GN-ID4 (anti-HPI/HCP, rat IgG2A), showed intense islet cell cytoplasmic staining. In contrast to the anti-HPI
The effects of phlorizin on several parameters of β-cell function were studied with microdissected islets of obese-hyperglycemic mice. At a concentration of 10 mM, phlorizin significantly depressed insulin release, glucose transport, glucose oxidation, and the level of fructose 1,6-diphosphate, when tested in the presence of 10 mM glucose. Whereas 1 mM phlorizin inhibited glucose transport by abou
Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a
There is a well-documented tension in many nonprofts - particularly those seeking government contracts or working in areas that compete with the private sector - between the institutional logics of business-market and nonproft-mission. This paper presents a case study of a century old Swedish nonproft. It suggests that in the presence of competing hybrid logics, organizational actors respond accor
This paper discusses topicality in Icelandic grammar as realized in severalphenomena: referential third person pro drop in Old Icelandic, diverse typesof topic drop in Old and Modern Icelandic, and Narrative Inversion (declarativeVS clauses), also in both Old and Modern Icelandic. These phenomena all involveaboutness topics, given topics or both, thus showing that distinct types of topicality are This paper discusses topicality in Icelandic grammar as realized in several phenomena: referential third person pro drop in Old Icelandic, diverse types of topic drop in Old and Modern Icelandic, and Narrative Inversion (declarative VS clauses), also in both Old and Modern Icelandic. These phenomena all involve aboutness topics, given topics or both, thus showing that distinct types of topicality
We present calculations for attosecond atomic delays in the photoionization of noble-gas atoms based on the full two-color two-photon random-phase approximation with exchange in both the length and velocity gauge. Gauge-invariant atomic delays are demonstrated for the complete set of diagrams. The results are used to investigate the validity of the common assumption that the measured atomic delays
We determined whether disulfide-linked insulin peptides that are immunogenic in vitro for CD4+ T cells bind to major histocompatibility complex class II in vivo. Radiolabeled recombinant human insulin (rHI) was injected into BALB/c mice, and processed rHI peptides bound to I-A(d) molecules on different thymic antigen-presenting cells were characterized. The A6-A11/B7-B19 and A19-A21/B14-B21 disulf
OpenFlow flow tables in Open vSwitch contain valuable information about installed flows, priorities, packet actions and routing policies. Their importance is emphasised when collocated tenants compete for the limited entries available to install flow rules. OpenFlow flow tables are a security asset that requires confidentiality and integrity guarantees. However, commodity software switch implement
Models suggest that climate change mitigation now depends on negative emissions, i.e. the large‐scale removal of carbon dioxide from the atmosphere. This assumption has been criticised in the climate policy literature for being unfeasible and unjust. This article asks how critical scholars can make sense of, and contribute to these debates. It suggests that negative emissions can be conceived of a
Selling goods and providing services in public spaces is one of the most accessible occupations for many urban poor. However, use of public space for such occupations is often prohibited by local regulations, excluding street vendors from legally using this space for their survival. While significant research has been devoted to state efforts to control informality, less is known about the everyda
Wettability gradient in radial direction and evaporation rate gradient can cause droplet motion on a solid surface. Here a theoretical model is proposed. Besides, an equation of droplet velocity is derived on a solid surface. We consider the wettability and evaporation rate gradients are mainly caused by the chemical composition and surface roughness, only along the radial direction. Surface tensi
Cd13-x;In7Sb10 (x≈2.7, Y≈ 1.5) was synthesized in the form of millsized crystals from reaction mixtures containing excess cadmium. The intermetallic compound crystallizes in the rhombohedral space group R3m with α = 12.9704(4), c= 12.9443(5) Å, V= 1886.0(1) Å3, Z=3 and is isostructural to thermoelectric ß-Zn 4Sb3 and ßCd4Sb3. However, in contrast to these last two compounds Cd13-xInySb 10 is free
This study scrutinizes gender differences in adolescent problem behaviour and its potential determinants, simultaneously taking into account the individual and contextual level, including personality, family and country characteristics. Using the 2010 EU Kids Online Survey, we estimate multilevel models on 18,027 individuals from 24 European countries. In line with earlier research, we find that b
We present high statistics MC calculations of the static potential in three-dimensional SU(2) for a wide range of β values on a 243 lattice. The deviations from area law are unambiguously demonstrated by use of 2nd lattice R derivative. After a clear crossover at β=4.5 the data show signs of an effective string roughening up to β=6.5, while scaling is not strictly obeyed in this interval. Pure fer
Purpose In this paper, the authors challenge traditional views of project management and sustainable development as purportedly complementing each other. Rather, the authors apply a projectification perspective from a multi-disciplinary approach to sustainable development. The purpose of this paper is to demonstrate how we can better understand the interface between projects and sustainable devel
It has been suggested that the new (and controversial) endoscopic techniques are more successful than standard operation for the preservation of the ligamentous pulley function across the carpal tunnel and for the separation of the gliding structures from the subcutaneous tissues after release of the carpal ligament in carpal tunnel syndrome. We therefore decided to study the possible importance o
