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Lytic polysaccharide monooxygenases (LPMOs) are enzymes that bind polysaccharides followed by an (oxidative) disruption of the polysaccharide surface, thereby boosting depolymerization. The binding process between the LPMO catalytic domain and polysaccharide is key to the mechanism and establishing structure-function relationships for this binding is therefore crucial. The hyperfine coupling const
Adaptation in new environments depends on the amount of genetic variation available for evolution, and the efficacy by which natural selection discriminates among this variation. However, whether some ecological factors reveal more genetic variation, or impose stronger selection pressures than others, is typically not known. Here, we apply the enzyme kinetic theory to show that rising global tempe
Denna uppsats redogör för den senaste ändringen rörande tidsbegränsade anställningar i Lagen (1982:80) om anställningsskydd, samt undersöker huruvida syftet med den har uppnåtts. Dessutom undersöks huruvida den nuvarande regleringen behöver ändras ytterligare på grund av den kritik den fått beträffande att den enligt TCO och EU-kommissionen inte skulle uppfylla Visstidsdirektivets syfte. ResultateThis thesis gives an account of the latest change regarding fixed term employment in the Swedish Employment Protection Act (Lagen (1982:80) om anställningsskydd) and whether the purpose of it has been fulfilled. Furthermore, an investigation is made regarding whether this regulation needs further change due to accusations from TCO (The Swedish Confederation for Professional Employees) and the Euro
The phylogenetic relationships of the lichenised ascomycete family Stereocaulaceae were investigated with partial beta-tubulin, partial glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and SSU rDNA sequence data. Due to the marked length variation in the SSU rDNA sequences, the analyses were performed with direct optimization. The combined analysis of the beta-tubulin, GAPDH and SSU rDNA sequences
Ozone dry deposition measurements were carried out during approximately one year over a flat grass field in Portugal. The results show prominent diurnal and seasonal patterns in deposition flux, dry deposition velocity and surface resistance, especially for the daytime period. Dry deposition velocities vary diurnally from a minimum of 0.1 cm s(-1) during the night to a maximum of 0.7-0.5 cm s(-1)
Insertion of lithium in anatase TiO2, giving LixTiO2, is performed under ultrahigh vacuum (UHV) conditions and studied using synchrotron radiation based electron spectroscopy. Core level photoemission spectra are directly compared to results obtained after electrochemical insertion, illustrating the usefulness of the UHV approach. The growth of a state of mainly Ti 3d character in the band gap is
The exposure to Th-232 from TIG welding with thoriated electrodes has been determined at five different workshops. Welding with both alternating and direct current was investigated. The exposure levels of Th-232 were generally below 10 mBq m(-3) in the breathing zone of the welders. Two samples from AC welding showed significant higher exposure levels, probably due to maladjustment of the TIG weld
The aim of this study was to analyse whether the interleukin-1 (IL-1) and IL-6 gene polymorphisms were associated with the susceptibility of chronic periodontitis. Genomic DNA was obtained from 20 patients with chronic periodontitis and 31 periodontally healthy subjects. All subjects were of North European heritage. The test subjects were kept in a maintenance program after periodontal treatment b
Popular Abstract in Swedish Syftet med denna avhandling är att undersöka mötet mellan den kyrkliga överheten och de olika lokalsamhällena sådant som det tog sig uttryck vid de kyrkliga visitationerna. I fokus står biskopsvisitationerna men även de visitationer som prostarna genomförde tas upp till behandling. Undersökningsområdet är Växjö stift och den tidsmässiga avgränsningen är 1650-1760. De frThe aim of this thesis is to investigate the encounter of the ecclesiastical authorities with the local community, as reflected in the church visitations. The focus is on the bishops' visitations, but there is also a brief examination of the deans' visitations, which are used for a comparison of the two types of inspections. The geographical limit of the study is the diocese of Växjö in southern S
Semenogelins I and II are major coagulum-forming proteins in semen, and they are secreted mainly by the seminal vesicles. These proteins bind Zn2+ and act as substrates for prostate-specific antigen and transglutaminase. A variant semenogelin I lacking 60 amino acids has been described that occurs in different populations with an allele frequency of 1%-3%. To better understand the function of the
The behavior of DNA at different types of interfaces and how the formed structures DNA at an interface could be affected by cationic surfactant has been studied. Particular attention was paid to how the type of cationic surfactant and DNA (single or double stranded and length) affects the compaction/decompaction of DNA. Adsorption of DNA-cationic surfactant complexes is determined by a delicate ba
Nine patients with spondylarthropathy (SpA) (6 with ankylosing spondylitis and 3 with psoriatic arthritis) who had not responded properly to conventional DMARD therapy were treated with 3 infusions (at 0, 2 and 6 weeks) of the TNF alpha inhibitor infliximab (3 mg/kg), in combination with methotrexate. To measure the effect of treatment, patients were evaluated before as well as 8 and 12 weeks afte
We examined the interaction of GABA and the competitive inhibitor SR95531 at human α1β1γ2S and α1β1 GABAA receptors expressed in Sf9 cells. The efficacy and potency of inhibition depended on the relative timing of the GABA and SR95531 applications. In saturating (10 mm) GABA, the half-inhibitory concentrations of SR95531 (IC50) when coapplied with GABA to α1β1γ2S or α1β1 receptors were 49 and 210
A time domain method building on the concept of wave splitting is used to study direct wave propagation phenomena in weakly nonlinear media. The starting point is the linear wave equation with time-dependent coefficients. This means that the studied nonlinear medium in some sense has to be approximated with a nonstationary medium which changes while the wave passes through. For the nonstationary e
BACKGROUND: Earlier studies have found that transthyretin (TTR) is reduced in cerebrospinal fluid (CSF) from patients with major depressive disorder and that levels correlate negatively with suicidal ideation. The purpose of this study was to examine CSF-TTR in a cohort of suicide attempters with different psychiatric diagnoses and to further assess the relationship between CSF-TTR and suicidal be
Risk minimization is no longer a sufficient survival strategy for poor people in livelihood systems increasingly exposed to frequent extreme events. This calls for comprehensive adaptation to climate change. Within the climate change regime, adaptation is as central as mitigation but needs to be much more explicitly addressed at local, national and global levels. There is also a need for policy re
Two anionic fluorene-thiophene alternating copolymers, poly[9,9-bis(4-sulfonylbutoxyphenyl)fluorene-2,7-diyl-2,5-thienylene] (PBS-PFT) and poly [9,9-bis(4-sulfonylbutoxyphenyl)fluorene-2,7-diyl-2,2'-bithiophene-5,5'- diyl] (PBS-PF2T), have been synthesized and their solution behaviors in water studied by UV-vis absorption spectroscopy, fluorescence, and electrical conductivity and compared with th
The electroenzymatic reactions of Trametes hirsuta laccase in the pure organic solvent dimethyl sulfoxide (DMSO) have been investigated within the framework for potential use as a catalytic reaction scheme for oxygen reduction. The bioelectrochemical characteristics of laccase were investigated in two different ways: (i) by studying the electroreduction of oxygen in anhydrous DMSO via a direct ele
