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Goals concerning reduced car traffic are found in most European cities, indicating a potential change in local transport policy and land use planning, which have traditionally been very car-centric. This paper analyses goals and measures to reduce car traffic in Swedish municipalities’ long-term transport and land use plans. Theoretically, the paper is based on an understanding of policies as part
Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here,we describe the involvement of BRCA2 in O6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts. We show that BRCA2 physically associates and undergoes repair-mediated degradation with AGT. In contrast, BRCA2 w
Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus. The quantification of cell cycle markers first revealed
Permafrost thaw can substantially increase the total export of dissolved organic carbon (DOC) to aquatic systems. The effects for bio- and photo-degradable DOC, however, are poorly known, because previous studies have mainly targeted lakes and streams which are indirectly affected by permafrost, while direct experimental work on permafrost thaw is lacking. We thus incubated permafrost cores from a
Return to Kashgar – the Jarring Collection of Uyghur Manuscripts Kashgar was a major crossroads for trade and culture along the Eurasian Silk Route for thousands of years, a place where Turkic, Persian, Arab, Chinese and other groups interacted. The Lund University Library is privileged to hold some 600 handwritten books from the sixteenth to the twentieth centuries from cities in this region like
This article explains perceived loneliness among people in Europe by accounting for cultural factors as well as social isolation. Culturally, it measures the impact of both personal and societal individualism-collectivism on loneliness. It accounts for social isolation by looking at the separate effects of living alone, emotional isolation, and relational isolation. Using a 2014 European Social Su
This paper explores whether Article 11 TFEU, requiring that ‘[e]nvironmental protection requirements must be integrated into the definition and implementation of the Union’s policies and activities, in particular with a view to promoting sustainable development’ provides an environmental right within the EU’s constitutional setting. After setting out relevant features of rights and environmental r
Differential evolution is a real value encoded evolutionary algorithm for global optimization. It has gained popularity due to its simplicity and efficiency. Use of special kind of mutation and crossover operators differentiates it from other evolutionary algorithms. In recent times, it has been widely used in different fields of science and engineering. Among recently developed various variants o
The production of 1 ton of PVC requires 2.0 - 2.5 m3 of demineralised water. Some of the water is lost in the process, e.g. as vapor during the drying of the PVC or as sealing water, while approx. 80% of the water could potentially be recycled. In today’s installations only about 20 – 25% of the water recovered by the PVC decanter is used for flushing of the facilities, while 75 – 80% is dischar
In the current public discourse the phenomenon of insecurity is widely discussed since various kinds of social risks are becoming more widespread throughout European societies threatening biographical stability and status security. Given this there is a quest for a realignment of statEinterventions aiming at the (re-)production of stability and security. It is assumed that institutional arrangemen
The success of maternally transmitted endosymbiotic bacteria, such as Wolbachia, is directly linked to their host reproduction but in direct conflict with other parasites that kill the host before it reaches reproductive maturity. Therefore, symbionts that have evolved strategies to increase their host’s ability to evade lethal parasites may have high penetrance, while detrimental symbionts would
Cells, the basic units of living organisms, are well delineated and separated from the external environment by membranes. Capable of both enclosing the cellular constituents and allowing exchanges with the outside world, these membranes are only a few nanometers thick. All the membranes in a human body cover an area of a few hectares, but account for only a small part of our mass. To study the dyn
We present a new model for building up complete exclusive hadronic final states in high energy nucleus collisions. It is a direct extrapolation of high energy pp collisions (as described by Pythia), and thus bridges a large part of the existing gap between heavy ion and high energy physics phenomenology. The model is inspired by the old Fritiof model and the notion of wounded nucleons. Two essenti
Data on menstrual pattern, gynecological disorders and infertility were obtained from 51 chronic alcoholic women aged 20--42 years attending an outpatient clinic for alcoholics, using 51 randomly drawn age-matched healthy women as controls. A higher variability (P less than 0.05) in the duration of both menstrual cycle and menstrual flow was recorded in the chronic alcoholic women during active al
The analytical distinction between critical and problem-solving research is useful. At the onset of research, the latter takes the world as it is while the former questions it. Yet, in striving to integrate social and natural dimensions of sustainability such a distinction may surface as a methodological obstacle. We illustrate how combining critical with problem-solving approaches can help us ima
