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The aggregating proteoglycans (aggrecan, versican, neurocan, and brevican) are important components of many extracellular matrices. Their N-terminal globular domain binds to hyaluronan, but the function of their C-terminal region containing a C-type lectin domain is less clear. We now report that a 90-kDa protein copurifies with recombinant lectin domains from aggrecan and versican, but not from t

Background Many patients who are discharged from the hospital without receiving a clear-cut diagnosis of their chest pain continue to consume health care because of disabling physical and psychological symptoms. By identifying their experiences and concerns following hospitalization, an empirical basis for discussions on ways of improving the care of these particular patients will be obtained. Me

Three variants in the caspase recruitment domain 15/nucleotide-binding oligomerization domain 2 (CARD15/NOD2) gene have been shown to be associated with Crohn's disease (CD). There is a strong support for shared genetic determinants between various autoimmune and inflammatory diseases. In particular, linkage of type 1 diabetes (T1D) and other autoimmune and inflammatory diseases has been reported

Inflammation is a physiological response that may go uncontrolled and thereby develop in a chronic way. This seems to happen in many common diseases of autoimmune, degenerative, or allergic character. Rheumatoid arthritis (RA) is by definition a chronic disease with an autoimmune inflammatory attack on diarthrodial cartilaginous joints. The development of new treatment neutralizing cytokines invol

Cross sections for elastic production of J/psi mesons in photoproduction and electroproduction are measured in electron proton collisions at HERA using an integrated luminosity of 55 pb(-1). Results are presented for photon virtualities Q(2) up to 80 GeV2. The dependence on the photon-proton centre of mass energy W-gamma p is analysed in the range 40 <= W-gamma p <= 305 GeV in photoproduction and

The creation spectra of F centres by synchrotron radiation of 5-35 eV have been measured for Na6Al6Si6O24(NaI)(2x) and Na6Al6Si6O24(NaBr)(2x) optical ceramics at 8 and 80 K. The exciting photons cause the excitation and ionization of halogen ions (6-8 eV) and of an aluminosilicate carcass (8.5-31 eV) or the excitation of Na+ ions (32-35 eV). An exciting photon of 20-26 and 27-31 eV creates two or

The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorub

This overview focusses on the ubiquitous presence of immunohistochemically visible peptidergic nerves with vasodilatory function. The nerve fibres are primarily related to the parasympathetic system (vasoactive intestinal polypeptide or VIP), the sympathetic system including the adrenal medulla (enkephalins) and to the sensory system (substance P as well as calcitonin gene-related peptide, CGRP).

In this work the steady and unsteady flamelet models have been applied to soot formation in laminar and turbulent diffusion flames. The aim was to study how different model parameters affect soot formation in diffusion flames. It was shown that certain assumptions are more crucial in laminar diffusion flames than in turbulent ones. The soot formation in turbulent diffusion flames is more sensitive

This thesis consists of three essays on incomplete information in financial markets, two of which are theoretical, and one that is mainly of an empirical nature. All three essays concern parameter uncertainty, and they employ a continuous-time framework. The first essay, "The Effect of Information Quality on Optimal Portfolio Choice," analyzes the portfolio choices made by three types of agents,

The PIXE technique offers the possibility of scanning a single hair strand longitudinally with a millimetre proton beam for trace elements. However, the accuracy of the method has been questioned since the quantification of the mass concentration has been a serious problem. In this paper a specific beam-hair-detector geometry is assumed, and the correction factor accounting for the proton energy l

Aim: To investigate the association between the use of cellular or cordless telephones and the risk for salivary gland tumours. Methods: Cases were assessed from the six regional cancer registries in Sweden. Four controls matched for sex and age in five year age groups were selected for each case. A total of 293 living cases and 1172 controls were included. Results: There were 267 (91%) participat

BACKGROUND AND PURPOSE: The purpose of this study was to determine whether preoperative and postoperative enrichment of the environment can enhance the functional outcome after cerebral infarction in rats. METHODS: The right middle cerebral artery was ligated in adult spontaneously hypertensive male rats, and the functional outcome was studied for 12 weeks after the operation. Three groups were co

BACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was perfo

A new Reynolds stress transport model (RSTM) aimed for engineering applications is proposed with consideration of near-wall turbulence. This model employs the Speziale, Sarkar and Gatski (SSG) pressure strain term, the omega equation, and the shear stress transport (SST) model for the shear stresses at the near-wall region (say, y(+) < 30). The models are selected based on the following merits: Th