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INTRODUCTION: Dysfunction of the cerebral vasculature is considered one of the key components of Alzheimer's disease (AD), but the mechanisms affecting individual brain vessels are poorly understood.METHODS: Here, using in vivo two-photon microscopy in superficial cortical layers and ex vivo imaging across brain regions, we characterized blood-brain barrier (BBB) function and neurovascular couplin
Smart cities promote computational and data-driven understandings of the built environment and have the potential to reconfigure urban planning and governance practices in profound ways. Smart urbanisation is often presented as a politically neutral and socially beneficial approach to achieve urban sustainability goals but the emphasis on data gathering and algorithmic analysis and decision-making
In our article we focus on potentials and challenges that arise in the use of situational analysis for reflexive-relational transition research. We discuss how transitions can be mapped as transformation processes in the life course and mapping can function as reflective tool in research projects. We explore mapping transitions not only as static situations, but also in their complex processuality
Earlier descriptions of the expansion of fashion often centered on new areas of content such as first names, or scientific approaches. Here sociologists will see how an old area of fashion activity receives new treatment. The subject area is food, not in respect to vogue in dishes, but in reference to the preparation of food as a matter of vogue. The practical has become independent of the strictl
We investigate the tetragonal phase of the binary transition metal oxide CuO (t-CuO) within the context of cellular dynamical mean-field theory. Due to its strong antiferromagnetic correlations and simple structure, analysing the physics of t-CuO is of high interest as it may pave the way towards a more complete understanding of high-temperature superconductivity in hole-doped antiferromagnets. In
Management of urban hydrological systems requires a knowledge of short-term and small-scale rainfall properties. Small catchment areas, dense building structures, a high degree of impermeable areas, and resulting rapid runoff, mean that the properties of individual rain cells are important considerations. Accordingly, this paper characterizes mainly spatial rainfall properties on a scale suitable
Double perovskites are a promising family of lead-free materials that not only replace lead but also enable new optoelectronic applications beyond photovoltaics. Recently, a titanium (Ti)-based vacancy-ordered double perovskite, Cs2 TiBr6, has been reported as an example of truly sustainable and earth-abundant perovskite with controversial results in terms of photoluminescence and environmental st
OBJECTIVE: To explore the experience of using audience response systems (ARS) in postgraduate physiotherapy training.DESIGN: Qualitative interview study following the 'reflexive thematic analysis' by Braun and Clarke.SETTING: Higher education university.PARTICIPANTS: Ten Italian students (60% men, N=6; 40% women, N=4) agreed to partake in the interviews.RESULTS: We generated four themes. Specifica
When two putatively cryptic species meet in nature, hybrid zone analysis can be used to estimate the extent of gene flow between them. Two recently recognized cryptic species of banded newt (genus Ommatotriton) are suspected to meet in parapatry in Anatolia, but a formal hybrid zone analysis has never been conducted. We sample populations throughout the range, with a focus on the supposed contac
The aim of this paper is to contribute to the empirical question of the labour organisation and the gender division of labour in a semi-landless rural group, crofters (Swedish torpare), during the nineteenth century, and thereby also add to the larger question of the role of gender division of labour in the formation of a wagedependent class. The crofters’ households performed contract-defined cor
Several studies have investigated the effect of botulinum toxin A (BoNT-A) for managing chronic musculoskeletal pain, bringing contrasting results to the forefront. Thus far, however, there has been no synthesis of evidence on the effect of BoNT-A as an adjunctive treatment within a multimodal approach. Hence, Medline via PubMed, EMBASE, and the Cochrane Library-CENTRAL were searched until Novembe
It is a common technique in many fields of engineering to reinforce materials with certain types of fibres in order to enhance the mechanical properties of the overall material. Specific simulation methods help to predict the behaviour of these composites in advance. In this regard, a widely established approach is the incorporation of the fibre direction vector as an additional argument of the en
Complexity science refers to the theoretical research perspectives and the formal modelling tools designed to study complex systems. A complex system consists of separate entities interacting following a set of (often simple) rules that collectively give rise to unexpected patterns featuring vastly different properties than the entities that produced them. In recent years a number of case studies
Pharmaceutical companies regularly fund patient organisations. It is important for patient organisations’ credibility that there should be transparency regarding this financial support. In Europe, the pharmaceutical industry promises to deliver transparency through self-regulation, as opposed to legally binding provisions, but self-regulation’s effectiveness is contested. We compared the industry’
The lack of success of legal challenges made against externalisation policies of various kinds is taken up in this article written by three authors focusing on three very different contexts: Oceania, Europe and South America. This comparative analysis highlights that externalisation practices are hard to challenge across the globe in the courts but for a variety of reasons. In Oceania, there is a
