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Neuropathological and cell culture studies suggest that tau and alpha-synuclein pathologies may promote each other. To study the relevance and functional implications of these findings in vivo, we transduced hippocampal neurons of wild-type or human A30P alpha-synuclein transgenic mice with wild-type or P301S mutated human tau using an adeno-associated virus vector. Green fluorescent protein trans

Modeling Parkinson's disease remains a major challenge for preclinical researchers, as existing models fail to reliably recapitulate all of the classic features of the disease, namely, the progressive emergence of a bradykinetic motor syndrome with underlying nigrostriatal alpha-synuclein protein accumulation and nigrostriatal neurodegeneration. One limitation of the existing models is that they a

Recent data suggest that platelets not only control thrombosis and hemostasis but may also regulate inflammatory processes such as acute pancreatitis. However, the specific role of platelet-derived mediators in the pathophysiology of acute pancreatitis is not known. Herein, we examined the role of CD40 ligand (CD40L, CD154) in different models of acute pancreatitis. Acute pancreatitis was induced

Popular Abstract in Swedish Den psykiatriska tvångsvården av lagöverträdare är omfattande i Sverige. Omkring 1000 personer vårdas på olika omhändertagandenivåer – vårdtiderna är långa (median drygt 3 år). Omvårdnadspersonalen står för det mesta av behandlings- och rehabiliteringsarbetet med dessa patienter. Det finns nästan ingen nordisk forskning som har granskat verksamheten (det enda undantaget

Innovation has been regarded a crucial means by which organizations adapt to the changes in the environment. Previous studies have identified organizational culture as a key factor that influences innovation, suggesting that a culture with certain characteristics can lead to superior innovation performance. This culture is referred to as “innovation culture”, a notion which has recently enjoyed gr

A theoretical framework based on the process of how founders and members of a team make decisions during the establishment stage of their respective new ventures, is a relatively unexplored area in the entrepreneurship research field. I develop upon Sarasvathy’s (2001) framework, which is based upon the existence of two decision making processes; causation and effectuation, during the establishmen

Pausanias’ Hellados Periegesis has proven to be difficult to group with other ancient works, whether preserved or not. In light of its highly varied subject matter, it is tempting to sort Pausanias together with other authors of miscellanies from the second century AD, like Aelian and Athenaeus. Like the Deipnosophistae and the Varia historia among other works, the Periegesis is a collection of fa

Today's electrical energy conversion devices, such as motors, transformers, inductors and generators, are based on laminated magnetic cores for reduction of eddy current losses, imposing a two-dimensional magnetic flux distribution. Using a three-dimensional magnetic flux distribution while maintaining low magnetic losses requires new approaches to magnetic core materials. Soft Magnetic Composites

Snakes (Serpentes) are a diverse suborder of reptiles that, along with lizards and amphisbaenians, belong to the reptilian order Squamata. The phylogenetic position of snakes relative to lizards and amphisbaenians has been debated for about 140 years. Despite the many morphological and molecular studies that had been done, no consensus had been reached as to the phylogenetic position of snakes or

Some of the most consistently utilized terms in international environmental law are “sustainable development” and “sustainability”. Sustainable development is mentioned in virtually every domestic, regional and international laws on environment, energy and natural resources. This has led to the contentions by some scholars that the concept of sustainable development has matured into customary inte

Popular Abstract in Swedish Den nya stadens bibliotek Folkbiblioteket beskrivs ofta som en av våra mest omtyckta och uppskattade samhällsinstitutioner. Trots detta har både besöken och utlåningen av böcker minskat under senare år, filialer läggs ner och på många håll minskar personalstyrkan. I en tid när böcker kan köpas på bensinmacken och mycket av den information vi söker kan hittas på nätet tyThis dissertation explores how perceived challenges and changing conditions for public libraries are translated and enacted in a local library setting. In 2008, Malmoe City Library, a public library situated in the third largest city of Sweden, initiated an ambitious strategy for renewal and change of their services. The strategy was given the name The Darling Library and expressed a vision to enf

It is today commonplace that games and virtual worlds are not only multi-billion dollar businesses but also momentous socio-cultural phenomena that require critical attention. Massively Multiplayer On-line Games (MMOGs) are these days becoming recognized not only as grounds for play within ‘magic circles’ but also as complex and significant social spaces with 24-7 access to the millions of gamers

Every year about 15 million people are injured in traffic, 500,000 of these fatally. Developing countries are badly affected. During the worst years of the war in Nicaragua, more people died in traffic accidents than as a direct result of the war. Transport system and infrastructure have developed rapidly in developing countries, while little has been achieved in preventing accidents or lessening

Production of synthetic vehicle fuels from biomass is a hot topic. There are several alternative fuels to consider when evaluating properties such as cost of production and energy efficiency to both product and final use in a road vehicle. Thermochemical conversion via gasification and downstream synthesis of fuels as well as biochemical conversion of woody biomass to ethanol is considered in this

Introduction: Development of industrial yeast strains with high tolerance towards the inhibitors released during biomass pretreatment is critical for bioethanol production. Combining this trait with increased thermotolerance would result in a more efficient production via Simultaneous Saccharification and Fermentation (SSF) as well as reduced cooling costs. The aim of the present work was to devel

Objective. Patients with hepatitis C have been shown to have impaired health-related quality of life (HRQoL). The aim of this study was to determine HRQoL in patients in different stages of hepatitis C virus (HCV) and to compare HRQoL in HCV cirrhosis with non-HCV-induced cirrhosis. Material and methods. Out of 489 consecutive patients who fulfilled the inclusion criteria, 472 (96%) agreed to part

Popular Abstract in Swedish Tvärströms mikrofiltrering är en teknik för att avskilja partiklar med en storlek på ungefär en mikrometer (en tusendel av en millimeter) från vätskor. Exempel på tillämpningar är avskiljning av jästceller från öl, och avskiljning av bakterier från mjölk. I mikrofiltrering används membran (filter) med porer med en storlek på 0.1 - 10 mikrometer. Mikrofiltreringsmembran Crossflow microfiltration is a technique to separate suspended particles (or cells or droplets) from liquids by use of a membrane that is permeable for the liquid but impermeable for the particles. The permeate flow drives particles to the membrane surface, where they may be deposited and form a fouling layer. To limit the growth of this fouling layer a flow is applied tangentially to the membrane

The work described in this thesis represents a biophysical approach, mainly using nuclear magnetic resonance (NMR) spectroscopy, to investigate the impact of magnesium ions on the EF-hand calcium-binding proteins calmodulin and calbindin D9k, as well as the dynamics of these proteins at low calcium levels. The x-ray structure of magnesium-saturated calbindin D9k shows a magnesium ion in only one o

Cystatin C, a major extracellular cysteine proteinase inhibitor, is deposited as amyloid in brain haemorrhage patients with hereditary cystatin C amyloid angiopathy (HCCAA). A disease-causing mutation on the genetic level results in the substitution Leu68-->Gln (L68Q) in cystatin C, which causes protein instability. Besides carrying the L68Q substitution, cystatin C in amyloid deposits isolated fr