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Computational analysis of large-scale metagenomics sequencing datasets provides valuable isolate-level taxonomic and functional insights from complex microbial communities. However, the ever-expanding ecosystem of metagenomics-specific methods and file formats makes designing scalable workflows and seamlessly exploring output data increasingly challenging. Although one-click bioinformatics pipelin

The aim of this study was to assess to what extent receptive vocabulary could be explained by morphological knowledge, language majority/minority background and socioeconomic status (SES) for Swedish 8–11-year-old children. A total of 89 children participated, of whom n = 47 were L1 speakers (language majority) and n = 42 were L2 speakers (language minority). Morphological knowledge (MK) was asses

Direct laser writing (DLW) has arise interest in a variety of fields due to the capabilities that we get from the realization of 2D and 3D structures with high resolution fabrication techniques. Multi-photon lithography (MPL) relies on non-linear absorption effects, making possible the fabrication of metasurfaces with feature size beyond the diffraction limit. A new approach in this direction is t

Streptococcus pyogenes, also known as group A Streptococcus (GAS), is a Gram-positive bacterial pathogen responsible for approximately 500,000 deaths globally per year. Therefore, surveillance of invasive GAS infections is of critical importance in understanding societal transmission. In this study, we propose an optical DNA mapping (ODM)-based assay for strain-level typing of S. pyogenes. Fluores

Background. Vaccine immunogenicity is reduced in kidney transplant recipients (KTRs), especially in those using mycophenolate mofetil (MMF). Whether replacement of MMF by everolimus improves vaccine immunogenicity is unknown. Methods. KTRs were randomized 1:1 to continue MMF or switch to everolimus. Participants received one coronavirus disease 2019 (COVID-19) booster vaccination and two herpes zo

Surface water pollution consists of various pollutants like heavy metals (Cu, Cr, Pb, and Ni), metalloids (Se, As, and Ag), and organic pollutants (dyes, antibiotics, pharmaceuticals, pesticides, and phenolic compounds). The escalating issue of water pollution requires innovative solutions for mitigation and climate resilience. Although various advanced techniques are being developed for removing

AbstractBackground: Identification of patients at risk and prevention of acute postoperative pain (APOP) are central to individualized anesthesia and analgesia. Venous cannulation pain (VCP) has shown promise as a predictor of APOP. In the PeriOPerative Individualization Trial (POPIT), VCP was evaluated as a pain-sensitivity stratification method to guide anesthesia and reduce postoperative pain.

The downstream process of monoclonal antibodies (mAbs) is expensive and significantly contributes to overall manufacturing costs. One primary reason is the extensive consumption of water and chemicals required for preparing large volumes of various buffers, essential for multiple chromatography and filtration steps. Reducing the water consumption in biopharmaceutical processes is critical to drive

We update the HOMER method, a technique to solve a restricted version of the inverse problem of hadronization – extracting the Lund string fragmentation function f (z) from data using only observable information. Here, we demonstrate its utility by extracting f (z) from synthetic PYTHIA simulations using high-level observables constructed on an event-by-event basis, such as multiplicities and shap

Intolerance of uncertainty (IU), cognitive avoidance (CA), positive beliefs about worry (PBW) and a tendency to view everyday problems as threats, termed negative problem orientation (NPO), are cognitive vulnerabilities associated with symptoms of anxiety and depression in adults, with fewer studies examining all four vulnerabilities in youth. In this study, validated measures of IU, CA, PBW and N

Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children

Background Labels for neck pain after a motor vehicle crash (MVC) influenced recovery expectations and management preferences. Research is needed to understand why these expectations and preferences varied based on the label given. Aim To explore how people perceive different labels for neck pain after an MVC. Methods We performed a content analysis of qualitative data from a randomised controlled

Heme proteins are central to metabolism and stress responses but remain challenging to express recombinantly due to cytotoxicity and folding constraints. Phytoglobins (Pgbs) exemplify these difficulties, as expression protocols often fail to translate across protein species. Here, we used a cell-free protein synthesis (CFPS) platform powered by digital microfluidics to screen expression determinan

District heating is critical for low-carbon urban energy systems, yet most networks remain centralized in both heat generation and data ownership, fossil-dependent, and poorly integrated with digital, customer-centric, and market-responsive solutions. While artificial intelligence (AI), the Internet of Things (IoT), and automation offer transformative opportunities, their adoption raises complex c

Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,