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Introduction: Oral dopaminergic treatment is the cornerstone of Parkinson’s disease (PD) management. However, progressive shortening of oral levodopa’s effect, along with the limited efficacy of enzyme inhibitors and dopamine agonists, does not allow to adequately control motor and non-motor complications characterizing advanced PD. At this stage, device-aided therapies (DATs), including infusion
Obstructive sleep apnea (OSA) has been hypothesised to promote cancer via intermittent hypoxia, and assessing what happens when OSA is controlled by continuous positive airway pressure (CPAP) may provide valuable insight. We conducted a meta-analysis of three randomised controlled trials (SAVE, RICCADSA, ISAACC) assessing cancer incidence from adverse event data on neoplasms among OSA patients ran
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities a
Objectives ‒ The STarT Back screening Tool (SBT) captures patients with low back pain (LBP) at risk of worse prognosis. However, the SBT does not include assessment of multisite and chronic widespread pain (MS-CWP). The aim was to study the differences in prognostic factors in patients with LBP classified according to SBT or SBT in combination with MS-CWP, and the 1-year outcome regarding visits t
Imaging the orientations of crystallites in bone requires the usage of synchrotron X-ray radiation, which is a limited resource for researchers. Thus scans have historically been limited to either small regions or few samples. In the present study, we scan 16 full frontal cross sections of mouse femora. This makes it possible to study structure, orientation, and composition, statistically across m
In this study, we perform paleontological and sedimentary research of three sections, Tianjiayuanzi, Jiulongwan, and Qinglinkou, located within the carbonate platform of the Huangling Anticline in the eastern Three Gorges area, Yichang City, Hubei Province. The aim is to investigate the spatial distribution patterns of microfossils in silicified bands from the lower Member III of the Doushantuo Fo
Mycelial residues, also known as fungal necromass, represent a substantial fraction of soil organic matter (SOM) pools in terrestrial ecosystems worldwide. Although microbial decomposers are increasingly recognised as key drivers of fungal necromass carbon stock formation, the diversity and composition of their microbial predators—and the roles these predators play in mediating fungal necromass de
YchF is a universally conserved unconventional G protein. It is known to be involved in the translation of leaderless mRNA. However, leaderless mRNA is rare in Escherichia coli under normal culture conditions, so we analyzed E. coli YchF to clarify its function in vivo. First, bioinformatics analysis was performed, and then the growth and survival of ychF mutants were investigated. The results sug
This article discusses baptism as expressing the four-fold relationality of life based on God, creation, neighbour, and self, as found in the second narrative of creation in the book of Genesis. Based on this understanding of baptism, baptismal ecclesiology can be defined as an understanding of the church that is primarily grounded in the sacrament of baptism. Baptismal ecclesiology sheds light on
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Purpose: Prolonged stress leading to sick leave is a serious health problem, and it is crucial to find ways to support recovery. The aim of this review was to synthesize the results from qualitative research about what people with stress-related disorders experience as supportive for recovery. Methods: The systematic review was designed as a qualitative meta-synthesis following the recommendations
The estimation of high resolution spectrometer Instrument Spectral Response Functions (ISRFs) is crucial because an imperfect knowledge of these functions can induce errors in the measurements. The state-of-the-art for this problem currently relies on the use of parametric models, which frequently lack flexibility to accurately model real-world ISRFs. To address this limitation, this paper propose
The 2025 Boyle Lecture explores the partnership between science, technology, theology, and spirituality in addressing contemporary challenges. Reflecting on historical and modern dynamics, it emphasizes the need for transdisciplinary collaboration to avoid cultural poverty and handle the current polycrisis in a world prone to polarization, populism, protectionism, post-truth, and patriarchy. The l
