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Background and purpose: Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular endothelium may modulate BBB structural and functional dynamics, thereby affecting neuronal damage and recovery after ischemic stroke. The aim of this study was to investigate temporal and
This bachelor thesis examines how Sámi women and queer Sámi people's vulnerabilization is constructed through an indigenous feminist and western politics discourse in the report called Violence against Sámi women (Våld mot samiska kvinnor). By using critical discourse analysis and Fairclough’s three-dimensional model, the thesis shows that the report constructs Sámi women's vulnerabilizati
This thesis investigates the development of an object-oriented modular framework for PLC systems, intended for use at Etteplan, an international engineering consultancy. The thesis was motivated by recurring challenges in PLC projects, including unclear program flows, low code reusability, and limited scalability. These issues justify the need for a standardized framework grounded in the IEC 61131
Detta examensarbete tar fram ett förslag för en ny arena vid Norra Hovstallängen i Uppsala och undersöker hur en storskalig evenemangs- och idrottsbyggnad kan integreras i en av stadens mest centrala och strategiskt placerade platser, i nära anslutning till Uppsala centralstation. Platsens läge i staden väcker frågor kring hur en sådan framträdande yta bör användas, och vilket värde en storskalig
Denna studie undersöker hur människors välbefinnande i bostadsområden påverkas av utomhusmiljö och biofilisk design. Vi har valt särskilt fokus på Holma i Malmö, ett område som byggdes under miljonprogrammet. Syftet med studien är att analysera hur Holmas bostadsmiljö förhåller sig till biofilisk design både i nutid och i samband med renoveringar och framtida stadsomvandling. För att genomföra arbThis study examines how people’s well-being in residential areas is affected by the outdoor environments and biophilic design. We have chosen to focus specifically on Holma in Malmö, an area built during the million homes programme era. The aim of the study is to analyze how Holma’s residential environment relates to biophilic design, both in present time and in connection with renovations and pla
Den ökade efterfrågan och turismen i Stockholms skärgård har skapat en identitetsmässig konflikt, där bebyggelseutvecklingen främst drivs av kommersiella besöksnäringar och privata fritidshus. Skärgårdsmiljön balanserar idag mellan strikt skyddade naturområden och exklusiva, privatiserade strandtomter, vilket lämnar lite utrymme för ett levande permanentliv. För att skärgården ska förbli en fungerThe growing demand and tourism in the Stockholm archipelago have created a conflict of identity, where property development is primarily driven by commercial hospitality industries and private seasonal housing. Today, the archipelago environment balances between strictly protected natural areas and exclusive, privatized shorelines, leaving little room for a vibrant, year-round community. For the a
Climate change policies have stimulated a shift towards renewable energy sources such as biomass. The economic crisis of 2008 has also increased the practice of household biomass burning as it is often cheaper than using oil, gas or electricity for heating. As a result, household biomass combustion is becoming an important source of air pollutants in the European Union.This position paper discusse
With the growth of e-commerce, understanding the nuances of packaging performance and consumer expectations has become essential to enhancing the customer experience. In e-commerce, packaging is a key component of the overall consumer experience, directly influencing perceptions and expectations. Despite its importance, packaging often remains overlooked and is significantly understudied. This exp
The theory of optimal control on positive cones has recently identified several new problem classes where the Bellman equation can be solved explicitly, in analogy with classical linear quadratic control. In this paper, the idea is extended to minimax adaptive control, yielding exact solutions to instances of the Bellman equation for dual control. In particular, this allows for optimization of the
In this paper, we introduce a generalized dynamical unbalanced optimal transport framework by incorporating limited control input and mass dissipation, addressing limitations in conventional optimal transport for control applications. We derive a convex dual of the problem using dual optimal control techniques developed before and during the 1990s, transforming the non-convex optimization into a m
Timber structures often combine multiple lateral load-resisting systems whose interaction under serviceability loading remains insufficiently understood. This study presents a full-scale experimental investigation into the lateral response of a single-storey timber mock-up comprising lightweight timber frame wall diaphragms, a roof diaphragm, and a centrally positioned moment-resisting frame. Two
BACKGROUND: Air pollution is a major public health concern, contributing to cardiovascular and respiratory diseases. One of the main pathways by which air pollution affects cardiovascular health is through dysregulation of the autonomic nervous system (ANS), which impairs cardiac control. Hydrotreated vegetable oil (HVO) is a renewable fuel with unknown toxicity in comparison to conventional diese
Graphical methods for system analysis have played a central role in control theory. The Scaled Relative Graph (SRG) has recently emerged as a useful tool for stability analysis of feedback interconnections. In this letter, we further extend its applicability by showing how the SRG of a discrete-time linear-time-invariant (LTI) system can be computed exactly from its state-space representation usin
In diesem essential werden die aktuellen Probleme der Agenda 2030 zur Umsetzung der Nachhaltigkeitsziele im Bereich Gesundheit erläutert. Das weltweite Aufkommen von Zivilisationskrankheiten und die explodierenden Kosten in der medizinischen Versorgung stellen die Weltgemeinschaft in Zeiten von Corona und Krieg vor große Herausforderungen. Um einen weiteren Rückschritt in der globalen Gesundheitsv
Die Agenda 2030 hat sich zum Ziel gesetzt, eine Welt ohne Armut, Hunger und Krankheit zu schaffen und dafür zu sorgen, dass jeder Mensch ein Leben frei von Furcht und ohne Unterdrückung führen kann. Um dies zu erreichen, muss jeder Mensch auch ein Recht auf Bildung haben. Ganzheitliche Bildungskonzepte sind hierbei von großer Bedeutung, da mit ihnen ein Umdenken zu einer nachhaltigen Lebensweise i
In der Geschichte der Menschheit haben Seuchen und Plagen immer wieder eine Spur von Leid und Tod hinterlassen. Auch in der Zukunft werden wir nicht von Pandemien, die über uns hereinbrechen werden, verschont bleiben. Der Ausbruch von COVID-19 kann daher auch als der Beginn einer neuen Bedrohung, die von lebensgefährlichen Infektionskrankheiten ausgeht, angesehen werden. Ursache hierfür sind unter
Introduction: Malignant hyperthermia (MH) is a pharmacogenetic, hypermetabolic and potentially lethal reaction to potent volatile anaesthetics and the muscle relaxant succinylcholine. To improve the understanding of MH, the aim of this retrospective study was to describe the Swedish cohort with respect to clinical manifestations, demographics and genetic findings. Method: The Swedish MH Registry c
Proteoglycans with their attached negatively charged glycosaminoglycans (GAGs) play a crucial role in proper tissue morphology and function throughout the body. Their complex meshwork exists either as thin sheet-like basement membranes lining epithelial cells as in airway bronchial and alveolar epithelial tissue or as a meshwork-like interstitial extracellular matrix (ECM) that forms porous three-
Smooth muscle cell–related transcription factors have been associated with coronary artery disease in large genome-wide association studies, increasing their translational value for therapeutic investigations. Our study shows for the first time that FOXC1 is a major transcriptional regulator in vascular injury and atherosclerotic lesions, causally implicated in the disease. Functionally, our data
With climate change and urbanisation increasing wildfire risk in the wildland–urban interface (WUI), enhancing community evacuation preparedness is crucial. This study evaluates different data collection methods for measuring traffic flows during a community wildfire evacuation drill in Roxborough Park, Colorado, in June 2024. A multi-method strategy was applied, including drone footage, human obs
