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AimIntraoperative rectal washout is performed to eliminate exfoliated intraluminal cancer cells and thereby decrease the risk of local recurrence. Rectal washout in abdominoperineal resection has not been studied. The aim of this study was to assess the oncological outcome after rectal washout in abdominoperineal resection for rectal cancer and to find evidence as to whether rectal washout should
Background: Community services for Swedish people with intellectual disability (ID) are intended to support self-determination and integrity. Legislation does not allow the use of restrictive or coercive measures. Aim: The aim of this study is to identify the extent of, rationale for, and strategies staff believe would reduce the use of restrictive measures in group homes and daily activities serv
To limit global warming to 1.5°C, fossil fuel use must rapidly decline, but historical precedents for such large-scale transitions are lacking. Here we identify 147 historical episodes and policy pledges of fossil fuel decline in 105 countries and global regions between 1960 and 2018. We analyze 43 cases in larger systems most relevant to climate scenarios. One-half of 1.5°C-compatible scenarios e
NTRU is a lattice-based public-key cryptosystem that has been selected as one of the Round III finalists at the NIST Post-Quantum Cryptography Standardization. Compressing the key sizes to increase efficiency has been a long-standing open question for lattice-based cryptosystems. In this paper we provide a solution to three seemingly opposite demands for NTRU cryptosystem: compress the key size, i
Background: Nail psoriasis (NP) is common and of high importance in patients with psoriasis. Complete resolution of NP at week 24‒26 is an unambiguous nail outcome accessible for indirect treatment comparison of biologics. Objective: To evaluate the comparative efficacy of approved biologics in achieving complete resolution of NP at week 24‒26. Methods: A network meta-analysis (NMA) was conducted
Within the grand sandstone quarries of Gebel el-Silsila is a vast amount of unique symbolic representations; stylized iconographic and pseudo-scripted signs and marks that to some extent signify deities and their protection against demons, evil and mishaps. Like written protective formulae, these marks were placed within the quarries to symbolically safe-keep the quarry workers, and for expressing
BACKGROUND: Phaeochromocytoma is sometimes not diagnosed before surgery and may present as an adrenal incidentaloma. The aim of this study was to investigate differences in clinical presentation and perioperative outcome in patients with subclinical and symptomatic phaeochromocytoma, and in patients operated with and without preoperative α-blockade. METHODS: This was a retrospective observational
Transport energy conservation research in urban transport systems dates back principally to the Organization of the Petroleum Exporting Countries’ (OPEC) “Arab Oil Embargo” (1973–1974) and the Iranian revolution (1979), when global oil supplies became threatened and costs rose steeply. Two subsequent Gulf Wars (1991 and 2003) highlighted the dangerous geo-political dimensions of Middle-Eastern oil
Canada is one of the only nations in the world that offers universal health coverage that excludes outpatient prescription drug services. This means that citizens may find out their diagnosis free of charge, but must incur out-of-pocket expenses for prescription drugs dispensed outside of hospitals. This paper examines the prevalence of prescription drug coverage in Canada across various socioecon
Over the last decade, financial disclosure and its impact on equity markets has increasingly become an area of interest. Firms suffering from poor operating performance have been shown to disclose bias earnings estimates as a means of evading negative market reactions. In this thesis, we attempt to discern whether managers purposefully bias their earnings estimates in periods of credit quality det
The purpose of this paper is to compare a collection of control variates for Monte Carlo-valuation of spread options on three assets with a view towards energy markets and to lay a foundation for continued research on control variates, e.g. combinations of control variates and adaption for quasi-Monte Carlo. The paper builds upon previous research on option pricing using Monte Carlo-simulation and
In a progressively globalized world the catapults of economic globalization, is in large, due to increased flows of foreign direct investments (FDI) across the world. FDI flows are considered essential vehicles for economic growth and development. The complex entities that embody a multinational company (MNC ) are often simplified to encompass either an exploitation approach of LDCs by MNCs or the
The aim of this thesis has been to investigate the legal conditions and process for triggering Credit Default Swaps, which are derivative instruments to shift credit risk exposure between parties in an underlying financial instrument. The condition is called credit event and a case study has been done on the Greek credit event in 2012. The thesis shows that there is a clear and robust framework o
This essay addresses the needs of so called ‘climate migrants’. It focuses exclusively on the relocation of the population of Kiribati, a small island nation in the Pacific Ocean whose very existence is threatened by the effects of climate change. With the principles of causality, morality, capacity and community, Miller’s Connection Theory provides the study with a framework for discussing the di
Lytic polysaccharide monooxygenases (LPMOs) are enzymes that bind polysaccharides followed by an (oxidative) disruption of the polysaccharide surface, thereby boosting depolymerization. The binding process between the LPMO catalytic domain and polysaccharide is key to the mechanism and establishing structure-function relationships for this binding is therefore crucial. The hyperfine coupling const
BACKGROUND: Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a substantial issue in neonatal intensive care units worldwide. Current therapies to prevent or treat GMH-IVH are limited. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, and/or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonatal stud
