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Cities are key actors in reducing both the causes of climate change (mitigation) and its impact (adaptation), and many have developed separate mitigation and adaptation strategies and measures. However, in order to maximize outcomes, both scholars and practitioners are increasingly calling for more integrated and synergetic approaches. Unfortunately, related research remains scarce and fragmented,
Lung transplantation is the only option for patients with end-stage lung disease, but there is a shortage of available lung donors. Furthermore, efficiency of lung transplantation has been limited due to primary graft dysfunction. Recent mouse models mimicking lung disease in humans have allowed for deepening our understanding of disease pathomechanisms. Moreover, new techniques such as decellular
Savannas are inherently “disturbed” ecosystems, but the regularly recurring disruptions play such a fundamental ecological role (Scholes and Archer, 1997) that “episodic events” rather than “disturbance” may the more apt terminology. From an atmospheric perspective, fire is the most significant of these episodic events. Fires shape community species composition; tree to grass ratio and nutrient re
Ferromagnetic semiconductor thin layers of the quaternary (Ga,Mn)(Bi,As) and reference, ternary (Ga,Mn)As compounds, epitaxially grown under either compressive or tensile strain, have been characterized from a perspective of structural and magnetization homogeneity. The quality and composition of the layers have been confirmed by secondary-ion mass spectrometry (SIMS). A thorough evaluation of the
The Baltic Sea is one of the most eutrophied seas in the world, facing challenges with both hypoxia and algae blooms. In this study we analyse the effect of using different fishery policy instruments to reduce nutrient loads by removing fish biomass from the ecosystem. The study covers Danish, Finnish and Swedish pelagic fisheries. We distinguish between a private optimum maximising the net presen
The production and consumption of fossil fuels need to decrease significantly to meet the 2015 Paris Agreement's ambitious climate change goals. However, fossil fuels continue to receive significant amounts of government support. Although reforming fossil fuel subsidies can yield climate change mitigation benefits, the specific international and domestic political context and political economy of
ESA's Earth Explorer candidate mission A-SCOPE aims at observing CO2 from space with an active LIDAR instrument. This study employs quantitative network design techniques to investigate the benefit of A-SCOPE observations in a Carbon Cycle Data Assimilation System. The system links the observations to the terrestrial vegetation model BETHY via the fine resolution version of the atmospheric transpo
The paper presents a feasibility study for a Climate Prediction Data Assimilation System following the methodological approach of the Carbon Cycle Data Assimilation System (CCDAS). The usefulness of accurate gradient information for estimating process parameters of the spectral atmospheric circulation model PUMA on climate time-scales is investigated. Pseudo observations of the long-term mean surf
Humor is essential to social life, but it is often overlooked in the study of crime and other social problems. We introduce and make use of humor theory, emphasizing the theories of superiority and relief. Based on interviews with incarcerated men, we demonstrate how humor is used to criticize authorities, for self-aggrandizement, and to alleviate the pain of tragic experiences. Funny remarks and
The growth of a planetary core by pebble accretion stops at the so-called pebble isolation mass, when the core generates a pressure bump that traps drifting pebbles outside its orbit. The value of the pebble isolation mass is crucial in determining the final planet mass. If the isolation mass is very low, gas accretion is protracted and the
Botulinum neurotoxins (BoNTs), the most potent toxins known, are potential bioterrorism agents. It is well established that all seven serotypes of BoNTs (BoNT/A-G) require complex gangliosides as co-receptors. Here, we report that BoNT/DC, a presumed mosaic toxin between BoNT/D and BoNT/C1, binds and enters efficiently into neurons lacking complex gangliosides and shows no reduction in toxicity in
The Absolut Company har öppnat besökscentret Absolut Home i Åhus och detta har potential att medföra ett stort antal värden för orten. Forskarna har studerat bådeturistaktörers och Åhusbors syn på värden för att ta reda på hur de ställer sig till det nya besökscentret i sin ort.
The differences between two standard Monte Carlo models, LEPTO and ARIADNE, for deep inelastic scattering at small-χ is analysed in detail. It is shown that the difference arises from a 'unorthodox' suppression factor used in ARIADNE which replaces the normal ratio of parton densities. This gives rise to a factor that qualitatively is similar to what one would expect from BFKL dynamics for some ob
Understanding the origins of biodiversity has been an aspiration since the days of early naturalists. The immense complexity of ecological, evolutionary, and spatial processes, however, has made this goal elusive to this day. Computer models serve progress in many scientific fields, but in the fields of macroecology and macroevolution, eco-evolutionary models are comparatively less developed. We p
A promise of genomics in precision medicine is to provide individualized genetic risk predictions. Polygenic risk scores (PRS), computed by aggregating effects from many genomic variants, have been developed as a useful tool in complex disease research. However, the application of PRS as a tool for predicting an individual's disease susceptibility in a clinical setting is challenging because PRS t
The past years have seen the rise of genomic biobanks and mega-scale meta-analysis of genomic data, which promises to reveal the genetic underpinnings of health and disease. However, the over-representation of Europeans in genomic studies not only limits the global understanding of disease risk but also inhibits viable research into the genomic differences between carriers and patients. Whilst the
Parkinson’s disease (PD) is a complex, progressive neurological condition that impacts daily life and reduces life satisfaction (LS). To achieve and maintain high LS, persons with PD (PwPD) must go through a process of change to adapt to their new life situation. However, our knowledge about this process is very limited. The aim of this study was to investigate the process of change, and the main
In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen, Strepto
Translation termination in eukaryotes is governed by the concerted action of eRF1 and eRF3 factors. eRF1 recognizes the stop codon in the A site of the ribosome and promotes nascent peptide chain release, and the GTPase eRF3 facilitates this peptide release via its interaction with eRF1. In addition to its role in termination, eRF3 is involved in normal and nonsense-mediated mRNA decay through its
Purpose: Institutional and commercial web profiles that provide biobibliographic information about researchers are used for promotional purposes but also as information sources. In the latter case, the profiles' (re)presentations of researchers may be used to assess whether a researcher can be trusted. The article introduces a conceptual framework of how trust in researchers may be formed based on
