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Close encounters involving free-floating planets in star clusters

Instabilities in planetary systems can result in the ejection of planets from their host system, resulting in free-floating planets (FFPs). If this occurs in a star cluster, the FFP may remain bound to the star cluster for some time and interact with the other cluster members until it is ejected. Here, we use N-body simulations to characterize close star-planet and planet-planet encounters and the

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes. These autoantibodies are detectable for a variable period of time before diabetes onset. Thus, the occurrence of islet autoantibodies is associated with the beginning of the disease process. The age at, and order in, which autoantibodies appear may be associated with different genetic backgrounds o

From homothally to heterothally; mating preferences and genetic variation within clones of the dinoflagellate Gymnodinium catenatum

The chain-forming dinoflagellate Gymnodinium catenatum Graham is responsible for outbreaks of paralytic shellfish poisoning (PSP), a human health threat in coastal waters. Sexuality in this species is of great importance in its bloom dynamics, and has been shown to be very complex but lacks an explanation. For this reason, we tested if unreported homothallic behavior and rapid genetic changes may

The S3 State of the Oxygen-Evolving Complex in Photosystem II Is Converted to the S2YZ State at Alkaline pH

Here we report an EPR signal that is induced by a pH jump to alkaline pH in the S3 state of the oxygen-evolving complex in photosystem II. The S3 state is first formed with two flashes at pH 6. Thereafter, the pH is changed in the dark prior to freezing of the sample. The EPR signal is 90-100 G wide and centered around g = 2. The signal is reversibly induced with a pK = 8.5 ± 0.3 and is very stabl

Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain.

Multipotent stem/progenitor cells derived from human first trimester forebrain can be expanded as free-floating aggregates, so called neurospheres. These cells can differentiate into neurons, astrocytes and oligodendrocytes. In vitro differentiation protocols normally yield γ-aminobutyric acid-immunoreactive neurons, whereas only few tyrosine hydroxylase (TH) expressing neurons are found. The pres

Restricted clinical efficacy of cyclosporin A on rat transient middle cerebral artery occlusion

The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly reducing infarct size induced by transient middle cerebral artery occlusion (MCAO)

Cryptotephra sedimentation processes within two lacustrine sequences from west central Sweden

Distal tephra horizons, particularly within lacustrine sequences, are increasingly being used as time-synchronous marker horizons within palaeoclimatic and palaeoenvironmental investigations. As sedimentary features marking the presence of these so-called cryptotephras are absent to the naked eye, it is of some importance that the stratigraphic position representing primary airfall, and likewise t

Fragmentation of proteins in cartilage treated with IL-1. Specific cleavage of type IX collagen by MMP-13 releases the NC4 domain.

Degradation of bovine nasal cartilage induced by interleukin-1 (IL-1) was used to study catabolic events in the tissue over 16 days. Culture medium was fractionated by two-dimensional electrophoresis (isoelectric focusing and SDS-PAGE). Identification of components by peptide mass fingerprinting revealed released fragments representing the NC4 domain of the type IX collagen {alpha}1 chain at days

A high-density putative monomeric mucin is the major [(35)S]labelled macromolecular product of human colorectal mucins in organ culture.

We have studied the biosynthesis of mucins in organ cultures of human colon using isopycnic density-gradient centrifugation following pulse labelling with [35S]sulphate and [3H]-D-glucosamine. A high-density [35S]sulphate labelled component, of larger size than MUC2 monomers, appeared in the tissue and also in the medium. It was not degraded by reduction, trypsin digestion, digestion with chondroi

Hybrid Modelling of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics—A Survey

The Homogeneous charge compression ignition (HCCI) principle holds promise to increase efficiency and to reduce emissions from internal combustion engines. As HCCI combustion lacks direct ignition timing control and auto-ignition depends on the operating condition, control of auto-ignition is necessary. Since auto-ignition of a homogeneous mixture is very sensitive to operating conditions, a fast

An analysis of population genetic differentiation and genotype-phenotype association across the hybrid zone of carrion and hooded crows using microsatellites and MC1R.

Abstract The all black carrion crow (Corvus corone corone) and the grey and black hooded crow (Corvus corone cornix) meet in a narrow hybrid zone across Europe. To evaluate the degree of genetic differentiation over the hybrid zone, we genotyped crows from the centre and edges of the zone, and from allopatric populations in northern (Scotland-Denmark-Sweden) and southern Europe (western-central no

High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease

OBJECTIVE: Previous studies have shown possible neuroendocrine effects of GH. In the present study we investigated the incidence of mental disorders and the prevalence of mental distress and cognitive dysfunction in hypopituitary women with untreated GH deficiency compared to population-based controls.DESIGN AND PATIENTS: Thirty-three hypopituitary women with a median age of 64 years (range 39--77

Historical diversification of migration patterns in a passerine bird

Migratory strategies of birds require complex orientation mechanisms, morphological adaptations, and life-history adjustments. From an evolutionary perspective, it is important to know how fast this complex combination of traits can evolve. We analyzed mitochondrial control-region DNA sequences in 241 blackcaps (Sylvia atricapilla) from 12 populations with different migratory behaviors. The sample

Lactic acid bacteria fermentations in oat-based suspensions

Popular Abstract in Swedish Mjölk anses som det enda flytande livsmedlet som på naturlig väg innehåller de tre fundamentala byggstenarna, fett, protein och kolhydrater, vilket definierar ett livsmedel näringsmässigt. Majoriteten av världens vuxna befolkning är dock tvungen att ha en begränsad konsumtion av mjölk då toleransen för dess kolhydrat, laktos, minskar med vuxen ålder. Detta beror främst This thesis deals with the fermentation characteristics of lactic acid bacteria (LAB) in oat-based suspensions, with formulation work of fermented products based on oat and with nutritional studies of these products. Changes in structure in terms of viscosity and ropiness were studied when exopolysaccharide (EPS)-producing LAB strains, namely, Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772,

The Swedish Knee Arthroplasty Register. Validity and Outcome.

The Swedish Knee Arthroplasty Register (SKAR) was initiated in 1975 to prospectively follow patients operated on with knee arthroplasty. With revisions utilized as the end-point in survival analyses, it is of importance that all revisions of included patients are reported. To validate if revision status was correctly recorded, a postal survey was made among all living patients, registered as opera

Att göra region genom stadspolitik - America's Cup och gränslöshetens gränser

This article is based on a study of the sailing event America’s Cup in Malmö in the late summer of 2005. It serves the purpose of exemplifying a project of urban governance. Urban governance means that municipalities are engaged in implementing different strategies in order to strengthen their own position in the competition between cities and regions. The article’s main theme is the relation betw

Cornelis Vreeswijk. Artist - vispoet - lyriker

The six chapters of this study approach the work of Cornelis Vreeswijk from different perspectives with an emphasis on the motifs, poetic technique, and intertextuality of individual songs amd Iyrical texts. Vreeswijks s work is interpreted in the context of contemporary history and debate, the cultural tradition to which it belongs and important events in the author's life. The first chapter foc

Effects of a Novel Amphiphilic Graft Copolymer on Ternary Mixtures of Surfactant, Water, and Oil

An amphiphilic graft copolymer, with hydrophilic poly(ethylene glycol) monomethyl ether side chains grafted onto a hydrophobic poly(dodecyl methacrylate) backbone, has been synthesized. The side chains are water soluble and the backbone is soluble in oils such as cyclohexane and isooctane. The graft copolymer is not soluble in oil or water, but it is quite soluble in AOT oil-continuous microemulsi

Using Acoustic Differential Extraction to enhance analysis of sexual assualt evidence on a valveless glass microdevice

The isolation of male and female DNA is an important step in the analysis of sexual assault evidence. A vaginal swab with female epithelial cells and male sperm cells is obtained from the female, and it is vital to separate the male and female fractions in order to obtain a single-source DNA profile of the suspect. In the case of a low abundance of sperm cells, it is very important that no cells a

Impact of Power Amplifier Nonlinearities in Multi-user Massive MIMO Downlink

In this paper, we investigate the impact of power amplifier (PA) nonlinear distortion in pre-coded multi-user large antenna or massive MIMO downlink systems. First, detailed signal and system models are derived for the received signal at single-antenna user equipment (UE) under channel-aware linear precoding in the base-station combined with behavioral models for the individual PA units, covering