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BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee
In forensics, identifying and comparing DNA is common practice. One way to analyse DNA is through high-resolution DNA melting. When melting DNA experimentally, the rate of a given sequence of DNA denaturing from its double-helix form into two separate strands is measured as a function of temperature. In this thesis, the application of high-resolution DNA melting analysis to distinguish individual
This thesis examines how individuals form and enact political vegan identity through everyday practice, and the role digital media platforms play in mediating that process. Drawing on 12 semi-structured interviews with vegan participants across 4 groups defined by age and length of vegan practice – New Sprouts, Early Roots, Late Bloomers, and The Oakes – the study traces the specific processes thr
Biological phosphorus removal in cold-climate regions is historically challenged by suppressed kinetic rates and severe biomass washout during spring snowmelt events. This study evaluates the performance, resilience, and kinetic limitations of a pilot-scale Sequencing Batch Moving Bed Biofilm Reactor (SB-MBBR) for Enhanced Biological Phosphorus Removal (EBPR) un-der low temperatures (8.3–9.6°C) at
Pesticide use in agricultural landscapes creates environmental contamination that is heterogenous in space and time. Mobile organisms, such as bees, are exposed to multiple contamination sources when visiting patches that vary in the amount, timing and toxicity of pesticides used. Yet, environmental risk assessments (ERA) typically fail to consider this heterogeneity, in part because of the comple
Community cohesion is a recent concept in ecology referring to the varying levels of connectivity and integration between populations of different taxonomic or functional groups within ecosystems. Positive cohesion denotes positive interactions such as mutualism or facilitation, while negative cohesion implies negative interactions such as competitive exclusion or a preference for different habita
Sugar beet molasses is a low-value byproduct from the sugar industry. It contains significant amounts of sucrose (approx. 50% (w/w)), which can be used for many different applications, for example, as feedstock for the production of fuel (as ethanol) and biobased chemicals such as 5-hydoxymethyl furfural (HMF). To produce platform chemicals, sucrose is hydrolyzed into its monomeric C6 sugars: gluc
The toxicity of particulate matter (PM) is dependent on particle physical and chemical properties and is commonly studied using in vivo and in vitro approaches. PM to be used for in vivo and in vitro studies is often collected on filters and then extracted from the filter surface using a solvent. During extraction and further PM sample handling, particle properties change, but this is often neglec
Background: Cardiovascular disease (CVD) is a major global health issue, primarily caused by atherosclerosis. Psychological factors may play a role in the development and progression of CVD. However, the relationship between psychological factors and atherosclerosis is complex and poorly understood. This study, therefore, aimed to examine the association of psychological factors with (i) coronary
Abstract Fatty acids mobilized from triacylglycerol stores are a major energy source in humans. Mobilization occurs through the consecutive action of three lipases: adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). Whereas ATGL and MGL only hydrolyse tri- and monoacylglycerols, respectively, HSL has a broad substrate range and hydrolyses cholesterol
Popular Abstract in Swedish Transplantation av nervvävnad till hjärnan är inte en ny idé. Redan 1890, publiserade Thompson de första försöken att transplantera vuxen hjärnvävnad till det vuxna centrala nervsystemet och han rapporterade att vävnaden överlevde i sju veckor "without wholly losing its identity". Trots detta var det först under 1970-talet som metoderna för intracerebral nervcellstranspIntracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction in both animals models and Parkinson's disease, although problems still remain. The newly introduced technique of ex vivo gene transfer could serve as an alternative approach, possible avoiding some of the draw-backs of the embryonal tissue used in neuronal grafting. We have investigated the feasibli
Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. Classical reaction engineering was combined with genetic engineering to improve the production of chiral alcohols and kinetic resolution of racemic ketones with high enantiomer
The adsorption of different metal-organic complexes at surfaces was investigated by spectroscopic techniques (x-ray photoemission spectroscopy, x-ray absorption spectroscopy, resonant photoemission spectroscopy) and by scanning tunnelling microscopy. The investigation methods are able to provide atomic scale information on the studied systems, which moreover originates from the top-most atomic lay
We present new abundance determinations of neutron-capture elements Ge, Zr, Os, Ir, and Pt in a sample of 11 metal-poor (-3.1<=[Fe/H]<=-1.6) Galactic halo giant stars, based on Hubble Space Telescope UV and Keck I optical high-resolution spectroscopy. The stellar sample is dominated by r-process-rich stars such as the well-studied CS 22892-052 and BD +17°3248 but also includes the r-process-poor,
Popular Abstract in Swedish När vi äter kolhydrater, fett, protein och andra näringsämnen sker kemiska reaktioner i kroppen som kan liknas vid dom som sker när man eldar en brasa. Vid förbränning reagerar kolhydrater med syre och bildar koldioxid och vatten. Denna förbränning frigör den energi som funnits lagrad i kolhydraterna, i brasan i form av värme, och i kroppens celler omvandlas den till keNADH:quinone oxidoreductase, or complex I, is a large, complex and poorly understood bioenergetic enzyme in the respiratory chain of living organisms. The enzyme has a conserved core structure, comprising fourteen protein subunits: Seven subunits protrude from the membrane and contain a flavin prosthetic group and eight iron-sulfur clusters that guide electrons from the oxidation of NADH towards t
Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) with the help of glutathione (H-SG). It is currently unclear whether MG and H-SG are substrates of GlxI or whether the enzyme processes hemithioacetal (HTA), which is nonenzymatically formed from MG and H-SG. Most previous studies have concentrated on the latter mechanism. Here, we study the two-subs
Extensive diversity has been identified in the human heavy chain immunoglobulin locus, including allelic variation, gene duplication, and insertion/deletion events. Several genes have been suggested to be deleted in many haplotypes. Such findings have commonly been based on inference of the germline repertoire from data sets covering antibody heavy chain encoding transcripts. The inference process
