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Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Enzymes with a protein kinase fold transfer phosphate from adenosine 5'-triphosphate (ATP) to substrates in a process known as phosphorylation. Here, we show that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein polyglutamylation. SidJ is activated by host-cell calmodulin to polyglutamylate the SidE family of ubiquitin (Ub) ligases. Crystal structu

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs

Serine hydroxymethyltransferase (SHMT) is the major source of 1-carbon units required for nucleotide synthesis. Humans have cytosolic (SHMT1) and mitochondrial (SHMT2) isoforms, which are upregulated in numerous cancers, making the enzyme an attractive drug target. Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures.

Early identification of urban locations towards soundscape analysis

Soundscape management in a city implies mitigating harmful sounds and promoting useful ones, according to their environmental, social or cultural significance and considering a more human centered paradigm. The Soundscape approach does not consider sound as a waste but a resource and its application may reach more benefits than solely noise control actions. This conception conveys an emerging para

Vulnerable agency: fat, bodies and their making among youth in a Brazilian favela

Contemporary social and cultural conditions in Brazil, together with technological developments and social media have enabled more young people of the favela to participate in different spheres of public life. These social and cultural changes have brought diversified new images of what it means to be an embodied subject. In this article, I explore the ways in which the body holds a seemingly para

Gendered Justice Gaps in Bosnia-Herzegovina

A gendered reading of the liberal peacebuilding and transitional justice project in Bosnia–Herzegovina raises critical questions concerning the quality of the peace one hopes to achieve in transitional societies. By focusing on three-gendered justice gaps—the accountability, acknowledgement, and reparations gaps—this article examines structural constraints for women to engage in shaping and implem

Centrosome Movements Are TUBG1-Dependent

The centrosome of mammalian cells is in constant movement and its motion plays a part in cell differentiation and cell division. The purpose of this study was to establish the involvement of the TUBG meshwork in centrosomal motility. In live cells, we used a monomeric red-fluorescenceprotein-tagged centrin 2 gene and a green-fluorescence-protein-tagged TUBG1 gene for labeling the centrosome and th

The Significance of the Anointing of Jesus' Feet

In this paper I argue that the author of John singled out the feet in his description of the anointing of Jesus because he wanted to portray Jesus as a serving, suffering, and dying Anointed One of the Lord, and because he wanted to emphasize the notion that the lowly ones of God’s people also would be anointed with the Holy Spirit. In order to support this conclusion I argue that (1) the anointin

Pfisterer

©2011 Landes Bioscience. Do not distribute. www.landesbioscience.com Cell Cycle 3311 Cell Cycle 10:19, 3311-3316; October 1, 2011; © 2011 Landes Bioscience RepORt RepORt *Correspondence to: Malin Parmar; Email: Malin.Parmar@med.lu.se Submitted: 07/28/11; Revised: 07/29/11; Accepted: 08/01/11 DOI: 10.4161/cc.10.19.17584 Induced pluripotent stem cells (iPS cells) obtained by repro- gramming of adult

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/pfisterer.pdf - 2026-06-07

Publikationslista sapes mars 2016sv

1 Vetenskapliga publikationer från forskningsmiljön SAPES 2010 – 2016 Ahrenfeldt, E.J., Klatt, B.K., Arildsen, J., Trandem, N., Andersson, G.K.S., Tscharntke, T., Smith, H.G. and Sigsgaard, L. 2015. Pollinator Communities in Strawberry Crops - Variation at Multiple Spatial Scales. Bulletin of Entomological Research 105, 497-506. Albizua, A., Williams, A., Hedlund, K. and Pascual, U. 2015. Crop Rot

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/publikationslista_sapes_mars_2016sv.pdf - 2026-06-07

Björn Berglund

Professor emeritus Contact details Email: bjorn [dot] berglund [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Service point: 16 WebpageBjörn Berglunds profile in Lund University research portalPersonal website:http://internt2.geol.lu.se/personal/bnb/index.htmOther affiliations Professor emeritus Department of GeologyCurrent research within three main

https://www.geology.lu.se/bjorn-berglund - 2026-06-06

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JUNE 22 – JULY 3, 2026 INSA TOULOUSE, FRANCE SECOIAS SUMMER SCHOOL 2026 JOIN THE FUTURE OF AEROSPACE TECHNOLOGY Security and Communication In Aerospace Embedded Systems Immerse yourself in the heart of Europe’s aerospace capital - Toulouse - home to Airbus, Thales Alenia Space, Safran, and CNES. Over two weeks at INSA Toulouse, one of France’s top engineering institutes, you’ll explore how embedde

https://www.student.lth.se/fileadmin/lth/utbildning/studerautomlands/andra_filer/brochure_secoia_2026_official.pdf - 2026-06-06

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Master´s Dissertation Structural Mechanics Report TV SM -5135 M A G N U S SA M U ELSSO N W IN D LO A D S A N D B U ILD IN G A ER O D Y N A M IC S MAGNUS SAMUELSSON WINDLOADS AND BUILDINGAERODYNAMICS Detta är en tom sida! Copyright © 2007 by Structural Mechanics, LTH, Sweden. Printed by KFS I Lund AB, Lund, Sweden, September, 2007. For information, address: Division of Structural Mechanics, LTH, Lu

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5135.pdf - 2026-06-07

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Saco-S C /O Jusek M edlem sregistret Svarspost Kundnum m er 110633700 110 05 Stockholm B Please tape here Please tape here B-porto betalt: N o stam p required Please fold here Are you an academic graduate? Join a Saco-S association Our job is to create good conditions for academic graduates. In other words, to ensure that you have good conditions at work. Fo to sk ri ft A B | 1 60 7 | 5 0 00 e x |

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/hogskolan-dalarna/dokument/about-saco-s/ - 2026-06-07

23 heintz_farnqvist

23 heintz_farnqvist LTHs 7:e Pedagogiska Inspirationskonferens, 30 augusti 2012 Abstract—We claim that competitive elements can improve the quality of programming and algorithms courses. To test this, we used our experience from organising national and international programming competitions to design and evaluate two different contests in an introductory algorithms course. The first contest turned

https://www.lth.se/fileadmin/lth/genombrottet/konferens2012/29_Heintz_Farnqvist.pdf - 2026-06-07