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Preservation of protein conformation upon transfer into the gas phase is key for structure determination of free single molecules, for example using X-ray free-electron lasers. In the gas phase, the helicity of melittin decreases strongly as the protein's protonation state increases. We demonstrate the sensitivity of soft X-ray spectroscopy to the gas-phase structure of melittin cations ([melittin

JavaScript is a dynamically typed and object-based scripting language with runtime evaluation. It has emerged as an important language for client-side computation of web applications. Previous studies have shown differences in behavior between established JavaScript benchmarks and real-world web applications. However, there still remains several important aspects to explore. In this paper, we comp

We used the nationwide Swedish Family-Cancer Database to analyse the association of histology-specific brain tumours with other cancers in family members. Among 0-68-year-old offspring, 9414 patients with brain tumours were identified from 1961 to 2000, of whom, 3387 parents were diagnosed with any primary neoplasm. Astrocytoma, meningioma and neurinoma were the main histological types. Increased

G-quadruplexes (G4s) have long been implicated in the regulation of chromatin packaging and gene expression. These processes require or are accelerated by the separation of related proteins into liquid condensates on DNA/RNA matrices. While cytoplasmic G4s are acknowledged scaffolds of potentially pathogenic condensates, the possible contribution of G4s to phase transitions in the nucleus has only

With the aim to reach deeper insights into dynamics of resilience and resurgence in Sámi systems of knowledge, this article explores how Sámi worldviews and knowledges are enacted and passed on despite violent efforts of erasure by colonial state actors and settler colonialists. I analyze a variety of sources—interviews, a podcast, a documentary and a magazine—to highlight Sámi resilience and resu

PARP-family ADP-ribosyltransferases (PARPs) and sirtuin deacetylases all use NAD(+) as cosubstrate for ADP-ribosyl transfer. PARP inhibitors are important research tools and several are being evaluated in cancer treatment. With the exception of a few tankyrase inhibitors, all current PARP inhibitors mimic the nicotinamide moiety in NAD(+) and block the nicotinamide binding pocket. We report here t

Glycosidases are phylogenetically widely distributed enzymes that are crucial for the cleavage of glycosidic bonds. Here, we present the exceptional properties of a putative ancestor of bacterial and eukaryotic family-1 glycosidases. The ancestral protein shares the TIM-barrel fold with its modern descendants but displays large regions with greatly enhanced conformational flexibility. Yet, the bar

In recent decades there has been an increasing demand in environmental sciences for harmonized climatic data at large spatial scales and long periods. Here we present easyclimate, a software package to obtain daily climatic data at high resolution (0.0083°, ∼1 km) with R. The package facilitates the downloading and processing of precipitation, minimum and maximum temperatures for Europe from 1950

What do struggles for women’s and LGBTI+ rights in Russia, Turkey and the Scandinavian countries have in common? And what can actors who struggle for rights and justice in these contexts learn from each other? Based on a multisited ethnography of feminist and LGBTI+ activisms across Russia, Turkey and the Scandinavian countries, this Open Access book explores transnational struggles on various lev

FeCo nanoparticles exsolved from Co-doped Sm0.9FeO3 nanofibers with abundant oxygen vacancies (Vos) are proposed as an efficient electrocatalyst to promote nitrate reduction reaction (NITRR). Such catalyst achieves a maximum Faradaic efficiency (FE) of 90.3 % and a large NH3 yield of 17.2 mg h−1 mg−1cat. at a negatively shifted potential of −0.9 V in 0.1 M PBS with 0.1 M NaNO3, and the alloy nanop

Net Zero Energy Buildings, Net ZEBs, is one of many necessary measures for climate change mitigation as they may reduce the energy consumption in the building sector. The Net ZEB interacts with a grid infrastructure. It is therefore important to consider the interaction with the grid in the design phase. This paper reports an evaluation of a proposed design of a Net ZEB in the south of Sweden eva

For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation. c-MYC is a critical regulator of cell proliferation; T58 is central in a phosphodegron long recognized as a hotspot for mutation in ca