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Aggregation can be a major challenge in the development of antibody-based pharmaceuticals as it can compromise the quality of the product during bioprocessing, formulation, and drug administration. To avoid aggregation, developability assessment is often run in parallel with functional optimization in the early screening phases to flag and deselect problematic molecules. As developability assessme
Unesterified radioactive cholesterol, both bound to serum lipoproteins and dispersed in ethanol-saline, was injected into bile fistula and intact rats. Due to phagocytosis, mainly by the liver macrophages, intravenously injected cholesterol in ethanol-saline disappears from the bloodstream significantly faster than lipoprotein-bound cholesterol. Soon after the initial phagocytosis, the particulate
Archaeological 3D GIS provides archaeologists with a guide to explore and understand the unprecedented opportunities for collecting, visualising and analysing archaeological datasets in three dimensions.With platforms allowing archaeologists to link, query and analyse in a virtual, georeferenced space information collected by different specialists, the book highlights how it is possible to re-thin
We are currently experiencing an enduring global epidemic of obesity and diabetes. It is now understood that chronic low-grade tissue inflammation plays an important role in metabolic disease, brought upon by increased uptake of a so-called Western diet, and a more sedentary lifestyle. Many evolutionarily conserved links exist between metabolism and the immune system, and an imbalance in this syst
Electromagnetic induction (EMI) methods are often used to map rapidly large areas with minimal logistical efforts. However, they are limited by a small number of frequencies and by their severe ill-posedness. On the other hand, electrical resistivity tomography (ERT) results are generally considered more reliable, with no need for specific calibration procedures and easy 2D/3D inversion. Still, ER
The European Spallation Source Neutrino Super Beam (ESSνSB) project aims at a discovery of leptonic CP violation with a precise measurement of the CP phase angle. ESSνSB is characterized by an intense neutrino beam to be produced at ESS by a 5-MW proton beam, and the placement of the far detector at the second oscillation maximum. The aims of the near detector for ESSνSB are neutrino flux and inte
Grasslands are a prerequisite for rearing livestock, and livestock is the mainstay of people’s existence in drylands. As one Kenyan woman put it, “without grass there is no livestock, without livestock there is no life.” Based in the lowlands of Baringo County in Kenya’s Rift Valley, RAE (Rehabilitating Arid Environments) Ltd. has worked for 38 years to develop a successful socio-ecological model
Net primary production (NPP) is modeled for a coniferous forest in southern Sweden for 2001. The model is based on the light-use efficiency concept where NPP is calculated as a product of absorbed photosynthetically active radiation (APAR) and a light-use efficiency factor (ε). APAR is estimated from the fraction of APAR (FAPAR) multiplied with the daily total amount of incoming PAR. FAPAR is obta
The groundwater contamination risk in future climates was investigated at three locations in Sweden. Solute transport penetration depths were simulated using the HYDRUS-1D model using historical data and an ensemble of climate projections including two global climate models (GCMs), three emission scenarios and one regional climate model. Most projections indicated increasing precipitation and evap
Graph neural networks for crystal structures typically use the atomic positions and the atomic species as input. Unfortunately, this information is not available when predicting new materials, for which the precise geometrical information is unknown. We circumvent this problem by replacing the precise bond distances with embeddings of graph distances. This allows our networks to be applied directl
The nature of transient electronic states created by photoabsorption critically determines the dynamics of the subsequently evolving system. Here, we investigate K-shell photoionized atomic neon by absorbing a second photon within the Auger-decay lifetime of 2.4 fs using the European XFEL, a unique high-repetition-rate, wavelength-tunable x-ray free-electron laser. By high-resolution electron spec
Protein lysine acetylation is known to regulate multiple aspects of bacterial metabolism. However, its presence in mycobacterial signal transduction and virulence-associated proteins has not been studied. In this study, analysis of mycobacterial proteins from different cellular fractions indicated dynamic and widespread occurrence of lysine acetylation. Mycobacterium tuberculosis proteins regulati
Preservation of protein conformation upon transfer into the gas phase is key for structure determination of free single molecules, for example using X-ray free-electron lasers. In the gas phase, the helicity of melittin decreases strongly as the protein's protonation state increases. We demonstrate the sensitivity of soft X-ray spectroscopy to the gas-phase structure of melittin cations ([melittin
JavaScript is a dynamically typed and object-based scripting language with runtime evaluation. It has emerged as an important language for client-side computation of web applications. Previous studies have shown differences in behavior between established JavaScript benchmarks and real-world web applications. However, there still remains several important aspects to explore. In this paper, we comp
