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Copper (Cu) is considered to be an indispensable microelement for plants. Excessive Cu, however, is toxic and disturbs severalprocesses in the plant. The present study addressed the effects of ionic Cu (2.0 mMand 8.0mM) on mitosis, the microtubule cytoskeleton,and DNA in root tip cells of Allium cepa var. agrogarum L. to better understand Cu toxicity on plant root systems. The results indicated th
We have previously shown that the reciprocal translocation t(6;7) associated with the spontaneous immunocytoma of the Louvain rat (RIC) leads to the juxtaposition of myc to the IgH cluster. In 10 of 14 tumors investigated the breakpoints on the myc carrying chromosome were clustered in a 1.5 kb region 5' of the intact gene, proximal to the myc promoters. In this paper we describe the effect of the
We have previously identified 20 different fusidic acid-resistant alleles of fusA, encoding mutant forms of the ribosomal translocase EF-G. One of these, P413L, is used here as the starting point in selections for internal revertants, identifying 20 different pseudo-wild-type forms of EF-G. We have also identified two alleles of fusA previously isolated as suppressors of 4.5 S RNA deficiency. All
Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments in a high-throughput manner. To address this we designed and constructed two human synthetic antibody frag
The city of Moscow has been going through a transformation of its surface transport network during the past decade as part of a broader policy of urban beautification. Despite a renewed interest in public transport, this policy has led to the dismantling of the trolleybus system. This was met with resistance from various groups. Bringing together scholarly discussions on urban growth coalitions an
A long line of contemporary studies of religion in South East Europe links resurgent nationalism together with the revival of religion. These studies argue that the new nations and the nationhood of these states are grounded on an ideological use of religion and especially the Orthodox Churches. This type of argument has become a key feature of social scientific studies of religion, as Daniela Kal
In migratory birds, constraints due to breeding are relaxed during the non-breeding season and thus, social behaviours and spatial associations are potentially more directly coupled to food resources and habitats. Use of space and territorial behaviour has rarely been studied in Afro-Palearctic migrants. Variation in strategies could exist among species within the same habitat because of differenc
This article analyses how the launch of Sweden’s feminist foreign policy marked a change in Sweden’s digital diplomatic efforts. It draws on three strands of research: digital diplomacy, foreign policy analysis (FPA) and feminist scholarship. Informed by FPA, the article explores the relevance of political leadership, bureaucratic agency and political context as drivers of policy change, and, spec
Within-plant variation in seed size may merely reflect developmental instability, or it may be adaptive in facilitating diversifying bet-hedging, that is, production of phenotypically diverse offspring when future environments are unpredictable. To test the latter hypothesis, we analyzed patterns of variation in seed size in 11 populations of the perennial vine Dalechampia scandens grown in a comm
Humans require multiple services from ecosystems, but it is largely unknown whether trade-offs between ecosystem functions prevent the realisation of high ecosystem multifunctionality across spatial scales. Here, we combined a comprehensive dataset (28 ecosystem functions measured on 209 forest plots) with a forest inventory dataset (105,316 plots) to extrapolate and map relationships between vari
Streptococcus pyogenes (Group A streptococcus; GAS) is a human pathogen causing diseases from uncomplicated tonsillitis to life-threatening invasive infections. GAS secretes EndoS, an endoglycosidase that specifically cleaves the conserved N-glycan on IgG antibodies. In vitro, removal of this glycan impairs IgG effector functions, but its relevance to GAS infection in vivo is unclear. Using target
Much of the debates surrounding public space is currently centred on privatisation and how it has contributed to the erosion of publicness in public space. However, public ownership and management of public space does not necessarily guarantee its accessibility, inclusivity and publicness – highly curated and regulated public space that are publicly funded and operated can be just as restrictive a
PROBLEM: The embryo is protected from immunologic rejection by the mother, possibly accomplished by immunosuppressive molecules located in the placenta. We investigated the distribution and biochemical properties in placenta of the immunosuppressive plasma protein alpha 1-microglobulin.METHOD OF STUDY: Placental alpha 1-microglobulin was investigated by immunohistochemistry and, after extraction,
Optimized biogenic carbon fluxes for Europe wereestimated from high-resolution regional-scale inversions, uti-lizing atmospheric CO2measurements at 16 stations for theyear 2007. Additional sensitivity tests with different data-driven error structures were performed. As the atmosphericnetwork is rather sparse and consequently contains large spa-tial gaps, we use a priori biospheric fluxes to
Serine hydroxymethyltransferase 2 (SHMT2) regulates one-carbon transfer reactions that are essential for amino acid and nucleotide metabolism, and uses pyridoxal-5′-phosphate (PLP) as a cofactor. Apo SHMT2 exists as a dimer with unknown functions, whereas PLP binding stabilizes the active tetrameric state. SHMT2 also promotes inflammatory cytokine signalling by interacting with the deubiquitylatin
