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Zinc constitutes the second most abundant transition metal in the human body, and it is implicated in numerous cellular processes, including cell division, DNA and protein synthesis as well as for the catalytic activity of many enzymes. Two major membrane protein families facilitate zinc homeostasis in the animal kingdom, i.e., Zrt/Irt‐like proteins (ZIPs aka solute carrier 39, SLC39, family) and
Protein folding is the dynamic process by which a protein folds into its final native structure. This is different to the traditional problem of the prediction of the final protein structure, since it requires a modeling of how protein components interact over time to obtain the final folded structure. In this study we test whether a model of the folding process can be obtained exclusively through
Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton–proton collision. Such LLP signatures are distinct from those of promptly decaying particles t
In recruitment, promotion, admission, and other forms of wealth and power apportion, an evaluator typically ranks a set of candidates in terms of their perceived competence. If the evaluator is prejudiced, the resulting ranking will misrepresent the candidates’ actual ranking. This constitutes not only a moral and a practical problem, but also an epistemological one, which begs the question of wha
Forests are key components of European multifunctional landscapes and supply numerous forest ecosystem services (FES) fundamental to human well-being. The sustainable provision of FES has the potential to provide responses to major societal challenges, such as climate change, biodiversity loss, or rural development. To identify suitable strategies for the future sustenance of FES, we performed a s
The aim of this work is to investigate the improvement of image quality in few-view grating-based phase-contrast computed tomography (PCCT) applications via compressed sensing (CS) inspired iterative reconstruction on an in vitro mouse model. PCCT measurements are performed on a grating-based PCCT setup using a high-brilliance synchrotron source and a conventional tube source. The sampling density
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive bronchoscopic procedure, well established as a diagnostic modality of first choice for diagnosis and staging of non-small cell lung cancer (NSCLC). The therapeutic decisions for advanced NSCLC require comprehensive profiling of actionable mutations, which is currently considered to be an essential
Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydrop
Vehicle-to-everything (V2X) wireless communication is expected to play a key role in enabling complex Advanced Driving Assistance Applications, including the support of emerging autonomous vehicles. The development of V2X applications, especially safety-related, requires rigorous verification. Field trials, though, have to be supplemented with less expensive and more repeatable methods. Thorough V
Background: Internet gaming disorder (IGD) was recently added in the Diagnostic and Statistical Manual of Mental Disorder as a “condition for further studies.” There is no consensus regarding which rating scales should be used but many scholars suggest the GASA (Game Addiction Scale for Adolescents) and a ranking of the criteria, “the core approach” to avoid over-diagnosing of disordered gaming. M
In light of concerns about adolescent mental health, there is a need to identify and examine potential pathways to wellbeing in their daily lives. Outdoor environments can offer multiple pathways to wellbeing through opportunities for restoration, physical activity and socialising. However, urbanisation and new lifestyles revolving around the home and the internet are changing young people’s acces
Salinity Gradient Power - Reverse Electrodialysis (SGP-RED) is a promising membrane-based technology to harvest the energy of mixing from solutions of different ionic concentration. Unfortunately, currently available commercial ion exchange membranes – being not specifically designed for RED – are far from satisfying the requirements of this operation, especially when operated with hyper-concentra
IntroductionSmall bowel obstruction, infertility, and chronic abdominal pain are generally mentioned as the main clinical consequences of adhesion formation after abdominal surgery1,2. Difficulties experienced during reoperation are less pronounced consequences, but seem to have a huge impact. A large retrospective cohort study3 revealed that adhesiolysis was significantly associated with risk of
Det här dokumentet ger lokala politiker och tjänstemän ett processorienterat verktyg för att stärka förankringen (integreringen) av ekosystembaserad klimatanpassning i relevanta sektorer av kommunal verksamhet. Guiden presenterar systematiskt de nivåer och områden där förankring av ekosystembaserad klimatanpassning är viktigt, och möjliggör på så sätt planering och bedömning av åtgärder. Det övergThis guideline offers local government officers and local politicians process‐oriented assistance for integrating ecosystem‐based adaptation within relevant sectors of municipal administration with the aim of fostering sustainable urban development. It is thus an instrument to support leadership of this integration process. The levels and areas where integration of ecosystem‐based adaptation isrel
BACKGROUND: Resection is the cornerstone of curative treatment for many nonmetastatic gastric cancers (GCs), but the population treatment patterns remains largely unknown. This large international population-based study aimed at investigating the treatment patterns and trends for nonmetastatic GC in Europe and the United States and at exploring factors associated with resection.METHODS: Data of pa
The history of racial science, as it emerged in Sweden and in other European countries in the nineteenth and twentieth centuries, is a standard research topic today. But notions of race are not only produced in scholarly contexts; they are also generated in the mass media, popular culture, and politics. The history of racialisation cannot only be studied by focusing on academia, in other words. We
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: Tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to result in loss of cartilage proteoglycans, the source of tissue fixed charge density (FCD). In order to
