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IMPORTANCE An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression. OBJECTIVE To evaluate the prognostic value of tau positron emission tomography (PET) to predict clinical progression from MCI to dementia. DESIGN, SETTING, AND PARTICIPANTS This was a multicenter cohort study with external valid
In this article, we propose a post-processing scheme for the novel volumetric microscopy technique SILMAS. We demonstrate this scheme on data from an alpha-synuclein transgenic mouse brain. By combining structured illumination and axial sweeping, a SILMAS measurement provides a prerequisite for quantitative data extraction through improved contrast and optical sectioning. However, due to the techn
The term ‘artificial intelligence’ has arguably come to function in political discourse as, what Laclau called, an ‘empty signifier’. This article traces the shifting political discourse on AI within three key institutions of global governance–OHCHR, WHO, and UNESCO–and, in so doing, highlights the role of ‘crisis’ moments in justifying a series of pivotal re-articulations. Most important has been
Brazil has faced severe droughts in recent decades, significantly affecting agriculture, water supply, and hydropower generation, among other sectors. The Paraná River Basin, a major hub for hydropower, has been particularly affected, posing challenges for water management. To address this, we conducted a study to provide tailored climate information for the Brazilian hydroelectric sector. Given t
Established in 2015, the Multi-Stakeholder Engagement (MuSE) Consortium is an international network of over 120 individuals interested in stakeholder engagement in research and guidelines. The MuSE group is developing guidance for stakeholder engagement in the development of health and healthcare guideline development. The development of this guidance has included multiple meetings with stakeholde
Normalizing flows (NFs) have been shown to be advantageous in modeling complex distributions and improving sampling efficiency for unbiased sampling. In this work, we propose a new class of continuous NFs, ascent continuous normalizing flows (ACNFs), that makes a base distribution converge faster to a target distribution. As solving such a flow is non-trivial and barely possible, we propose a prac
The research presented here explores the nuances of data collection and sharing via digital platforms in everyday CrossFit coaching practice. There is a growing body of work on data and digital platforms in CrossFit, though currently there is a lack of research on the role of coaches in these processes. Empirically grounding the digital fitness practices of CrossFit coaching is essential for our u
The ATLAS trigger system is a crucial component of the ATLAS experiment at the LHC. It is responsible for selecting events in line with the ATLAS physics programme. This paper presents an overview of the changes to the trigger and data acquisition system during the second long shutdown of the LHC, and shows the performance of the trigger system and its components in the proton-proton collisions du
Protein and lactose of cheese whey can be separated using ultrafiltration membranes and lactose can be hydrolyzed by β-galactosidase. This study investigated the integration of ultrafiltration and enzymatic hydrolysis for simultaneous protein concentration and lactose hydrolysis. β-galactosidase was immobilized on ceramic membrane via surface activation with gelatin and subsequent enzyme cross-lin
Crohn’s disease (CD) and ulcerative colitis (UC) are the two main types of inflammatory bowel disease (IBD). The prevalence of these conditions is approximately 0.7%. With the advent of new treatments and improved management algorithms throughout the last century, the mortality rates associated with these conditions have decreased steeply. However, IBD is still a major cause of lifetime morbidity.
In-situ remediation through the injection of bioremediation fluids is becoming increasingly common for treating contaminated sites. Contaminants are targeted for treatment either directly at the source zone or through injections that form a permeable reactive barrier to prevent further transport of the contaminants. Commonly, multiple injections are performed in a grid covering an area of strategi
This chapter addresses perinatal mortality in early modern Lutheran Sweden by examining the interplay between religious and medical birth practices and fetal and infant concepts and imagery. Early modern European birth intervention strategies aimed at securing baptism: the spiritual survival of unborn individuals. Lutheran doctrine demanded a complete live birth before baptism, yet emergency solut
Under the UK-focused Greenhouse gAs and Uk and Global Emissions (GAUGE) project, two new tall tower greenhouse gas (GHG) observation sites were established in the 2013/2014 Northern Hemispheric winter. These sites, located at existing telecommunications towers, utilized a combination of cavity ring-down spectroscopy (CRDS) and gas chromatography (GC) to measure key GHGs (CO2, CH4, CO, N2O and SF6)
This study aims to compare the effectiveness of different Pharmacokinetic-Pharmacodynamic (PK-PD) models for administering Propofol and Remifentanil, two critical agents in anesthesia. Initially, different PK models were introduced: one for Propofol based on the Schnider model and another for Remifentanil using the Minto model. Alternatively, both drugs were modeled using the Eleveld models. The P
Corrosion of steel components embedded in concrete is detrimental to the structural integrity and their intrinsic function,such as the leak-tightness of containment liners in nuclear reactor containment buildings. Detection of embedded linercorrosion is a challenging task due to the concrete’s heterogeneity and the large dimensions of containment buildings.This initial study explores early-stage d
