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Introduction: Synaptic dysfunction and degeneration is one of the earliest events in Alzheimer's disease (AD) and the best correlate of cognitive decline. Thus, identification and validation of biomarkers reflecting synaptic degeneration to be used as prognostic biomarkers are greatly needed.Method: Solid-phase extraction and parallel reaction monitoring mass spectrometry were used to quantify 17

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Phosphorus induced eutrophication of freshwaters is one of the great global challenges. As the critical threshold concentration for eutrophication is very low, there is a strong need for development of phosphate sorbents with high affinity and selectivity. Single sheet iron oxide (SSI), a nanomaterial prepared from oxidation and exfoliation of layered iron(II)-iron(III) hydroxide (green rust), is

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Electromagnetic fields exist all around us. Through evolution, nature has developed tools to interact and use these fields, where our eyes are a spectacular example. Humans have a long history of developing structures and objects of their own to alter and interact with these fields. Today they are important cornerstones in society, with radiating devices such as cell phones, Wi-Fi routers, or car

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This paper suggests a taxonomy for labeling deviating patterns in district heating (DH) customer data. The taxonomy contains several fault labels intended to register information about faults in the DH systems that cause deviations in customer data. This taxonomy is needed because the DH industry is currently missing a unanimous way to label identified faults. The lack of a taxonomy makes it hard

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In this article, we consider the properties of the Pesaran CD test for cross-section correlation when applied to residuals obtained from panel data models with many estimated parameters. We show that the presence of period-specific parameters leads the CD test statistic to diverge as the time dimension of the sample grows. This result holds even if cross-section dependence is correctly accounted f

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Motivated by the influence of (micro-)cracks on the effective electrical properties of material systems and components, this contribution deals with fundamental developments on electro-mechanically coupled cohesive zone formulations for electrical conductors. For the quasi-stationary problems considered, Maxwell’s equations of electromagnetism reduce to the continuity equation for the electric cur

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This paper presents research on the need for boundary spanners in organizations that has an offshore insourcing strategy for the IT-function. The research question addressed was: How does an offshore insourcing strategy influence the need for having boundary spanners? Empirical data was collected using a case study in three phases, including semi-structured and structured interview in a multinatio

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The renovation of buildings involves multidisciplinary issues and multistakeholder involvement, which makes the process complex to manage. The purpose of this paper is to present a transparent, openly accessible, adaptable framework to ensure a sustainable renovation process, covering the technical, environmental, economic, social, and cultural historical aspects to be considered by the various ac

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An e-library for standardized chemotherapy regimens has been developed and is, since 2015, available as a national resource for healthcare staff and patients in cancer treatment in Sweden. The library was developed in a user-centered design process and is now evaluated to understand how it is used and if it is used in the intended way. This paper presents the e-library in brief together with preli

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PURPOSE: Interventional radiology techniques cause radiation exposure both to patient and personnel. The radiation dose to the operator is usually measured with dosimeters located at specific points above or below the lead aprons. The aim of this study is to develop and validate two fast Monte Carlo (MC) codes for radiation transport in order to improve the assessment of individual doses in interv

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Sweden has set ambitious goals concerning future sustainable cities. Solar energy plays a vital role in this transformation, since it directly relates to our health and well-being, on-site renewable energy production, economic activity, and social interaction. Therefore, prioritizing solar access already in the urban design phase is important to create equal possibilities for everyone living and w

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The increased use of cloud and other large scale datacenter IT services and the associated power usage has put the spotlight on more energy-efficient datacenter management. In this paper, a simple model was developed to represent the heat rejection system and energy usage in a small DC setup. The model was then controlled by a reinforcement learning agent that handles both the load balancing of th

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This paper is an attempt to advance research on walking at a neighborhood level of analysis for people with disabilities by proposing a theoretical model that combines the knowledge of two disciplines: traffic planning and environmental psychology. The aim is to provide guidance for a discussion and a plan for future interdisciplinary investigations by proposing a model that accounts for the dynam

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The concept of ‘resilience’ is not independent of physical, psychological, cultural, and political environments. The human capacity to sustain is ingrained in the contextualization and internalization of resilience. This makes the notion of resilience an interdisciplinary construct requiring theoretical and methodological triangulation. A decontextualization of the concept ‘resilience’ and an atte

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This work presents an on-chip memory subsystem envisioned for real-time applications performing Oriented FAST and Rotated Brief (ORB) feature extraction for Simultaneous Localization and Mapping (SLAM) systems. For autonomous navigation of battery-powered devices, feature-based SLAM is a computationally frugal alternative to direct methods. This paper thoroughly analyses ORB multiple memory access

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Objective: Termination in psychodynamic therapy (PDT) is a potentially conflictual and turbulent phase for patients, with a risk for increases in symptoms. However, few studies of PDT have assessed symptoms frequently enough during treatment to determine whether such setbacks are in fact common in PDT. Methods: In a doubly randomized clinical preference trial, 217 adults (female = 163; M age = 34.

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Measurements of the decay of electric fields, formed spontaneously within vapour-deposited films ofcis-methyl formate, provide the first direct assessment of the energy barrier to secondary relaxation in a molecular glass. At temperatures far below the glass transition temperature, the mechanism of relaxation is shown to be through hindered molecular rotation. Magnetically-polarised neutron scatte