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Male infertility

Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation o

Springtime migratory restlessness and departure orientation of great knots (Calidris tenuirostris) in the south compared to the north yellow sea

Background: The motivation of birds to proceed with migration is associated with both endogenous and exogenous factors. According to their migratory situation and to the characteristics of stopover sites, birds might exhibit migratory motivation differently among sites. Although migratory motivation of migrating birds has been well stud-ied in many species, the investigation of the same species in

Excitement is not the only experience

Expectations of what constitutes a positive customer experience have changed over time. Developments in technology and digital services have enabled new kinds of customer experience. As have new store formats and diversified retail offerings. Regardless of the form it has taken, customer experience has always been of paramount importance to retail managers. And it continues to be so. Over 50% of p

Messy customer journey self-mapping

The new retail landscape is complex. New types of touchpoints and new store formats mean messy, non-linear customer journeys with multiple online and offline touchpoints. If we want to understand these journeys, and what value customers derive from new and innovative touchpoints, we must use methods that allow them to explain their own complex customer journeys in all their messy glory!

The modified Medical Research Council scale misclassifies exertional breathlessness among people referred for exercise testing

BACKGROUND: Exertional breathlessness is a major symptom in cardiorespiratory disease and is often assessed using the modified Medical Research Council (mMRC) questionnaire. The mMRC might underestimate exertional breathlessness in people with impaired exercise capacity who have reduced their physical activity to avoid the symptom. We aimed to evaluate the ability of mMRC to detect abnormally high

Substance Use Problems and Death of Despair in a 32-Year Follow-Up Study of Suicide Attempters Examined at a Medical Emergency Inpatient Unit

Deaths of despair (DoD), encompassing suicide, drug overdose, and alcohol-related mortality, are often linked to social and psychological distress. This study examined the long-term risk of DoD among individuals previously hospitalized for suicide attempts, with a focus on substance use problems and psychiatric disorders as potential risk factors. A prospective cohort of 1044 individuals admitted

A high-repetition rate attosecond light source for time-resolved coincidence spectroscopy

Attosecond pulses, produced through high-order harmonic generation in gases, have been successfully used for observing ultrafast, subfemtosecond electron dynamics in atoms, molecules and solid state systems. Today’s typical attosecond sources, however, are often impaired by their low repetition rate and the resulting insufficient statistics, especially when the number of detectable events per shot

Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study

PurposeWe studied the promising Alzheimer biomarker plasma tau phosphorylated at threonine 231 (p-tau231) in a cohort of cardiac arrest patients who survived to intensive care to predict long-term neurological outcomes. We also compared it to total tau (t-tau), which has demonstrated predictive abilities of neurological outcome post-cardiac arrest.MethodsThis observational multicentre cohort study

Designing and developing the Professional Development Course for External Examiners

A 2015 review of external examining in the UK assessed the effectiveness of the external examining system in safeguarding academic and quality standards in higher education. The development of the Professional Development Course for External Examiners was a key response to the recommendations from this review. This chapter contains an overview of the structure of the course, the key messages commu

A Feasibility Trial on Intranasal Evaporative Cooling for Acute Migraine in an At-Home Setting

BACKGROUND: A significant proportion of people with migraine do not achieve sufficient relief of their acute migraine symptoms with the currently available medications. A previous study showed that intranasal evaporative cooling reduced headache and migraine-associated symptoms when given in an outpatient clinic setting. This study aimed to evaluate the feasibility of self-administering the same i

Effect of nanoparticle concentration and surfactants on nanofluid pool boiling

Silica nanofluids are prepared with a concentration varying from 0.001 vol.% to 0.003 vol.%, and pool boiling of the nanofluids is experimentally investigated. It is found that critical heat flux and heat transfer coefficient increase by a maximum of 62.66% and 45.88% compared with deionized water. The best boiling performance is achieved with the nanofluid of 0.002 vol.%. In addition, the paper f

Maternal and fetal haemopexin and α1-microglobulin concentrations in pre-eclamptic IVF pregnancies according to presence of corpus luteum at embryo transfer

Research questionDo pregnancies with corpus luteum show different maternal and fetal plasma concentrations of the scavenger proteins haemopexin and α1-microglobulin compared with pregnancies without corpus luteum in preeclampsia?DesignCase-control study of 160 singleton pregnancies: 54 naturally conceived, 50 by IVF after fresh embryo transfer or frozen embryo transfer (FET) in natural cycle (pres

The impact of AI on inclusive learning communities

The possibilities of generative artificial intelligence (GenAI) are both exciting and potentially concerning in many aspects of higher education. One concern may be that the increased use of GenAI tools exacerbates and perpetuates structural inequities due to the material used to train these tools, counteracting efforts to build inclusive learning communities. In this chapter, we consider how univ

Self-assessed performance-based function test versus patient-reported outcome measures for knee and hip osteoarthritis

BACKGROUND: Physical function constitutes a key component of outcome assessment for almost all osteoarthritis interventions. The aim was to compare physical function measured using a self-assessed performance-based test versus self-reported function using questionnaires among individuals with knee or hip osteoarthritis (OA) participating in a digital exercise and education therapy.METHODS: We anal

Despite antiretroviral therapy (ART) rollout, most cases of tuberculosis among people with HIV in Adama, Ethiopia, occur before ART initiation

Introduction: Although antiretroviral therapy (ART) leads to reduced tuberculosis (TB) incidence in people with HIV (PWH), ART recipients remain at higher risk of TB compared to HIV-seronegative people. With accelerated ART rollout in sub-Saharan Africa, increasing proportions of TB cases among PWH in people receiving long-term ART have been reported. Objective: To determine TB notifications among

Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19

BackgroundCritical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma endostatin at intensive care unit (ICU) admission as a biomarker for AKI, renal replacement therapy (RRT), and 90-day mortality in COVID-19.Method

Prenatal PFAS exposure associates with DXA assessed markers of adiposity in 7-year-old children from the Odense Child Cohort

The global increase in childhood overweight and obesity presents significant public health concerns due to its long-term health implications. Emerging evidence suggests that exposure to endocrine disrupting chemicals, such as per- and polyfluoroalkylated substances (PFAS), may be obesogenic and contribute to adiposity. This study aimed to investigate the association between prenatal PFAS exposure

Analysis of heat and mass transport characteristics in microchannel reactors with non-uniform catalyst distributions for hydrogen production

Purpose: The purpose of this paper is to investigate the heat and mass transport characteristics in microchannel reactors with non-uniform catalyst distributions. Design/methodology/approach: A two-dimensional model is developed to study the heat and mass transport characteristics in microchannel reactors. The heat and mass transport processes in the microchannel reactors with non-uniform catalyst