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Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults
Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate r
Commentary: Weighing up the Dead and Missing: Reflections on Inverse-probability Weighting and Principal Stratification to Address Truncation by Death.
Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure
Most previous genetic epidemiology studies within the field of osteoporosis have focused on the genetics of the complex trait areal bone mineral density (aBMD), not being able to differentiate genetic determinants of cortical volumetric BMD (vBMD), trabecular vBMD, and bone microstructural traits. The objective of this study was to separately identify genetic determinants of these bone traits as a
Women who gave birth to girls with Turner syndrome: maternal and neonatal characteristics
Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characterist
Near Ambient Pressure X-ray Photoelectron Spectroscopy Study of the Atomic Layer Deposition of TiO2 on RuO2(110)
The atomic layer deposition (ALD) of TiO2 on a RuO2(110) surface from tetrakis(dimethylamido) titanium and water at 110 degrees C was investigated using near ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) at precursor pressures up to 0.1 mbar. In addition to the expected cyclic surface species, evidence for side reactions was found. Dimethylamine adsorbs on the surface during the TDMA
Real-World Outcome Analysis of Continuously and Intermittently Treated Patients with Moderate to Severe Psoriasis after Switching to a Biologic Agent.
Background: Clinical studies of continuous versus intermittent biologic therapy for moderate to severe psoriasis demonstrate improved efficacy with continuous treatment. Objective: To analyse Swedish real-world data of continuously and intermittently treated biologic-naïve patients after switching to a biologic agent. Methods: This is an observational study based on PsoReg, the Swedish registry fo
Region-Specific Nutrient Intake Patterns Exhibit a Geographical Gradient within and between European Countries
Until recently, the study of nutrient patterns was hampered at an international level by a lack of standardization of both dietary methods and nutrient databases. We aimed to describe the diversity of nutrient patterns in the European Prospective Investigation into Cancer and Nutrition (EPIC) study at population level as a starting point for future nutrient pattern analyses and their associations
Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone
Previous genome-wide association (GWA) studies have identified SNPs associated with areal bone mineral density (aBMD). However, this measure is influenced by several different skeletal parameters, such as periosteal expansion, cortical bone mineral density (BMDC) cortical thickness, trabecular number, and trabecular thickness, which may be under distinct biological and genetic control. We have car
Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study
Purpose. We assessed the association between smoking cessation and prospective weight change in the European population of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of smoking. Eating out of home And obesity (EPIC-PANACEA) project. Methods. The study involved more than 300,000 healthy volunteers, recruited between 1992 and 200
A prospective cohort study on risk of acute pancreatitis related to serum triglycerides, cholesterol and fasting glucose
Background/objectives: To investigate risk for acute pancreatitis related to moderately elevated triglycerides, cholesterol and fasting glucose. Methods: This was a prospective cohort study in Malmo, Sweden of 33 346 subjects investigated 1974 - 1992 and followed until December 31, 2006. Baseline investigation included a self-administered questionnaire and analysis of serum triglycerides, choleste
Equity in maternal, newborn, and child health interventions in Countdown to 2015: a retrospective review of survey data from 54 countries
Background Countdown to 2015 tracks progress towards achievement of Millennium Development Goals (MDGs) 4 and 5, with particular emphasis on within-country inequalities. We assessed how inequalities in maternal, newborn, and child health interventions vary by intervention and country. Methods We reanalysed data for 12 maternal, newborn, and child health interventions from national surveys done in
The Rh(100)-(3 × 1)-2O structure.
The O adsorption on Rh(100) has been studied using high resolution core level spectroscopy, low energy electron diffraction and scanning tunnelling microscopy. In addition to the well known (2 × 2), (2 × 2)-pg and c(8 × 2) structures at coverages of 0.25, 0.5 and 1.75 ML respectively, an intermediate (3 × 1) structure with a coverage of 2/3 ML is identified.
A variant near the interleukin-6 gene is associated with fat mass in Caucasian men
Context: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. Objective: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these
Developing a teaching and learning culture – the case of Faculty of Engineering at Lund University
The first chapter of this paper will give an overview of different ways of developing a university’s teaching and learning. There are many single activities that individually deal with the topic in a positive direction, such as teacher training, develop learning environments, develop teacher reward systems, etc. Traditionally educational development has been about these single activities focusing
Taking pedagogic responsibility for the difference between plagiarism and cheating
The Swedish Higher Education Ordinance states1 in Chapter 8, section 1 (Svensk Förfat- tningssamling [SFS] 1993:100) that disciplinary action can be taken against a student who “at- tempt to deceive during examinations or when academic work is otherwise assessed”. Suspicion of such behaviour is to be reported to the disciplinary board, which in turn has to establish the students intent. The main f
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Integration of the computer-based design analysis activity in the engineering design process - A literature survey
Computer-based design analysis is nowadays a common activity in most development projects. Used for design evaluation, verification, validation, or as a support for design exploration, it fulfils an important support function for the engineering designer, thus making it essential to have an operationally efficient and effective integration between both the engineering design and design analysis ac
