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Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease. Several studies have identified transcriptional subtypes of mCRPC, but comprehensive analysis of prognostic gene expression pathways has been limited. Therefore, we aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression-based pathways with clinical out
A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.
The modern food industry faces the challenge of catering to diverse consumer preferences while maintaining efficiency and profitability. Rapid shifts in consumer trends, emerging technologies, and evolving regulations make it difficult for companies to keep pace, often resulting in inefficiencies and lost opportunities. The vast amount of data generated across production, supply chains, and market
Nonlinear effects play a central role in photonics as they form the foundation for most of the device functionalities such as amplification and quantum state preparation and detection. Typically the nonlinear effects are weak and emerge only at high photon numbers with strong drive. Here we present an experimental study of a Josephson junction -based high-impedance resonator. We show that by takin
BACKGROUND: A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long-term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown. METHODS AND RESULTS: We included 8364 women (age ≤65 years) undergoing first coronary artery stentin
This paper deals with numerical investigations of cross laminated timber (CLT) beams. Previous investigations have revealed discrepancies between experimental test results and suggested design methods regarding shear force capacity of such beams. To gain further understanding of the failure behaviour and the shear force capacity, nonlinear finite element analyses have been performed, using a cohes
Probing the internal structure of crystalline materials is vital for understanding and optimizing their functional properties, especially in semiconductors and multiferroics, where nanoscale distortions such as strain and lattice tilt can dramatically affect performance. Among various characterization tools, X-ray diffraction imaging offers a unique combination of deep penetration, nondestructive
BACKGROUND: Previous case-control studies have reported aberrations of the gut microbiota in individuals with prediabetes. The primary objective of the present study was to explore the dynamics of the gut microbiota of individuals with prediabetes over 4 years with a secondary aim of relating microbiota dynamics to temporal changes of metabolic phenotypes.METHODS: The study included 486 European p
A common type of inhalation medicine uses a dry powder formulation where the active pharmaceutical ingredient (API) is attached on the surface of carrier particles, often in combination with additional components. The spatial distribution of the API on the carrier particle is critical for the release into the lungs and thus for the efficacy of the drug. In this work, we use ToF-SIMS imaging in com
BackgroundDietary shift is necessary for improving public health, mitigating climate change, and achieving the Sustainable Development Goals. Adaption of climate-friendly diets might prevent chronic diseases and reduce mortality; however, consuming diets with a low climate impact have been suggested to increase risk of some micronutrient deficiencies.ObjectivesThis study aimed to examine whether s
It is by now a common trope that youth climate activism has become a ‘global phenomenon’. Yet, it also has significant regional variations. This literature review analyses eighteen academic articles on the topic of youth climate activism in Asia. We found that the literature from Asia overall had ambitions to contextualise and nuance international scholarship on youth climate activism. This was ac
The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive
Background and Aims: Previous studies have shown that procalcitonin (PCT) concentration is elevated in patients with liver disease without evidence of bacterial infection. We aimed to investigate the association between elevated PCT and the future risk of liver disease. Method: PCT was measured in 3897 individuals without known liver disease in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-
Background: Regular monitoring of healthcare quality and equity is crucial for informing decision-makers and clinicians. This study explores the application of generative AI, more specifically large language models (LLMs), to facilitate standardized monitoring of healthcare quality using the established framework Analysis of Individual Heterogeneity and Discriminatory Accuracy (AIHDA). The study i
BACKGROUND: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.METHODS: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017
Combining multiple III-V materials into axial nanowire heterostructures has enabled the fabrication of custom nanowire-based devices useful for a wide range of applications. However, our ability to form axial heterostructures between arbitrary combinations of III-V compounds is impeded by a lack of information on the dynamics of the heterojunction formation process, often resulting in suboptimal h
RNA modifying enzymes play a pivotal role in reshaping gene expression programs in response to diverse intracellular and extracellular cues, thereby maintaining cellular homeostasis. When dysregulated, these enzymes are increasingly implicated in the onset and progression of various diseases. While traditionally recognised for their catalytic functions, mounting evidence suggests that many RNA mod
Binary nanoparticles (BNPs), composed of two distinct materials, offer tailored properties advantageous for various applications, including enhanced catalytic, magnetic, and optical behavior. Among the synthesis methods for BNPs, spark ablation stands out for its capability to produce multicomponent nanostructures with tunable compositions. This study investigates the mixing dynamics of material v
Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder. How exactly mutant GFAP eventually leads to white and gray matter deterioration in AxD remains unknown. GFAP is known to be expressed also in neural precursor cells in
