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BackgroundThe purpose was to evaluate the prognostic impact of aryl hydrocarbon receptor (AHR) genotypes in relation to lifestyle and adjuvant treatments in breast cancer.MethodsAHR genotyping was performed on genomic DNA from 1701 patients included 2002–2016 in Lund, Sweden, and followed for up to 15 years. Eight AHR polymorphisms and eight haplotypes were analysed using survival and interaction

Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B (MTNR1B) is robustly associated with increased risk of T2D. This single-nucleotide polymorphism (SNP; rs10830963; G-allele) is an expression quantitative trait locus (eQTL) in human pancreatic islets, conferri

Background During the last decade, evidence has emerged on selective glomerular hypofiltration syndromes (SGHS), defined by selectively reduced filtration of middle-sized molecules irrespective of kidney function and resulting in a low ratio between cystatin C- and creatinine-based estimated glomerular filtration rates (eGFRcys/eGFRcr). We aimed to examine whether SGHS is a hallmark of premature k

Background: The global food system is a major contributor to climate change, accounting for about one-third of human-induced greenhouse gas emissions (GHGE). Shifting toward plant-based diets offers potential benefits for both planetary health and chronic disease prevention. However, epidemiological evidence linking dietary GHGE to health outcomes remains limited and inconsistent. Objective: To ex

1 Studenthandbok 2019/20 INSTITUTIONEN FÖR STRATEGISK KOMMUNIKATION 2 Välkommen! Strategisk kommunikation är ett flervetenskap- ligt ämne som hjälper oss att förstå, analysera och granska verksamhetskommunikation inom företag, offentliga organisationer och myndigheter utifrån ett holistiskt perspektiv. Kommunikation är grund- läggande i alla typer av arbeten. Förmågan att kom- municera väl blir al

https://www.isk.lu.se/sites/isk.lu.se/files/studenthandbok_2019_svenska_0.pdf - 2026-06-03

Low back pain is common and negatively impacts quality of life and workplace productivity. However, few studies have focused on small- and medium-sized enterprises (SMEs) where risk factors are prevalent. This cross-sectional study examined the association and structural relationships between physical and social factors in low back pain among Japanese SME workers. We analyzed survey data collected

We present the design and implementation of a portable transfer system equipped with an integrated electrochemical cell that enables the controlled transfer of samples between an electrochemical environment and an ultrahigh vacuum (UHV) system without air exposure. This setup allows for the preparation of well-defined model surfaces, their electrochemical modification, and subsequent structural an

Electrochemical reactions like water-splitting or corrosion initiate at electrode-electrolyte interface, and in some cases can also be closely linked. In particular, the oxygen evolution reaction (OER) in electrolyzers and the oxygen reduction reaction (ORR) in fuel cells are not only sluggish but can also lead to severe catalyst degradation. A fundamental understanding of these processes is there

The activity and stability of an electrocatalyst is governed by the structural and chemical changes occurring at the solid–liquid interface. While single crystal electrodes have often served as model systems to elucidate structure–function relationships, extending these insights to more realistic polycrystalline electrodes requires experimental techniques with spatial resolution that can operate u

Using ultra-broadband transient terahertz (THz) spectroscopy, complemented by transient absorption (TA) and photoluminescence (PL) measurements, we directly track the generation and relaxation of photoexcited hot carriers, as well as the ultrafast formation of excitons in the transition metal phosphorus trichalcogenide NiPS3, with a temporal resolution of sub-100 fs. A subset of excitons exhibits

1 Studenthandbok 2019/20 INSTITUTIONEN FÖR STRATEGISK KOMMUNIKATION 2 Välkommen! Strategisk kommunikation är ett flervetenskap- ligt ämne som hjälper oss att förstå, analysera och granska verksamhetskommunikation inom företag, offentliga organisationer och myndigheter utifrån ett holistiskt perspektiv. Kommunikation är grund- läggande i alla typer av arbeten. Förmågan att kom- municera väl blir al

https://www.isk.lu.se/sites/isk.lu.se/files/studenthandbok_2019_svenska.pdf - 2026-06-03

Objective: To evaluate the effects of excluding fatty tissue in QSM of human knee cartilage. Materials and methods: Gradient echo images from 18 knee-healthy volunteers were acquired, from which chemical shift corrected field perturbation maps were calculated. Based on these, QSM maps were reconstructed using morphology enabled dipole inversion and one of three masking alternatives: (1) excluding

Correlated electron physics is intrinsically a multiscale problem, since high-energy electronic states screen the interactions between the correlated electrons close to the Fermi level, thereby reducing the magnitude of the interaction strength and dramatically shortening its range. Thus the handling of screening is an essential ingredient in the first-principles modeling of correlated electron sy

By combining ab initio downfolding with cluster dynamical mean-field theory, we study the degree of correlations in monolayer, bilayer, and bulk breathing-mode kagome van der Waals materials Nb3(F, Cl, Br, I)8. Our new material-specific many-body model library shows that in low-temperature bulk structures the Coulomb correlation strength steadily increases from I to Br, Cl, and F, allowing us to i

Transposable elements (TEs) are mobile genetic sequences comprising around 50% of human DNA. TEs shape gene regulatory networks in development, pluripotency and inflammation, and are implicated in a number of neurological disorders. Therefore, TEs are tightly controlled by epigenetic regulators which form a complex repressive network throughout different stages of development. However, while the r

Objective: There is a well-established association of oral manifestations in the non-infectious chronic diarrhoeal conditions namely, Morbus Crohn, ulcerative colitis, and coeliac disease. Such a connection may exist also for the remaining non-infectious chronic diarrhoeal conditions, that is irritable bowel syndrome (IBS) and microscopic colitis (MC). Materials and methods: A systematic search wa

The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, c

BACKGROUND AND OBJECTIVE: The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) is evolving rapidly. Real-world data (RWD) are essential to understand actual treatment use and outcomes. This study aimed to describe treatment trajectories and clinical outcomes in a large, multicenter RWD cohort under the PIONEER project. METHODS: Eight European and US databases (2016-2020

Diffraction gratings are among the most fundamental optical elements. They are essential in ultrafast optics for manipulating the spectral phase of coherent ultrashort light pulses in grating stretchers, compressors, and pulse shapers. In this work, we have exploited an effect associated with diffraction from a single grating, which can produce large amounts of spatially dependent GDD. Leveraging