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Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing. Innovative strategies to enhance bone repair, including the delivery of osteoprogenitor cells or of potent cytok
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Understanding the behavioral properties of single molecules or larger scale populations interacting with single molecules is currently a hotly pursued topic in nanotechnology. This arises from the potential such techniques have in relation to applications such as targeted drug delivery, early stage detection of disease, and drug screening. Although label and label-free single molecule detection st
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Intresset för probiotika har vuxit de senaste åren. Förutom att vara ha en förebyggande effekt och vara en effektiv behandling mot akut diarré, finns det forskning som indikerar att probiotika kanske kan användas för att förebygga andra sjukdomar, t.ex. tjocktarmscancer. Utmaningen med probiotika är att för att den ska ha någon effekt, krävs det att tillräckligt många levande bakterier når tjocktaThe interest in probiotics has grown in the last few years. In addition to being effective in treating and preventing acute diarrhea, there are indications that it might be possible to use probiotics to prevent other diseases such as colon cancer. The challenge with probiotics is that for it to have any effect, enough viable bacteria must reach the colon. To deliver live probiotics to the colon, i
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Typical for Western classical music is the process of interpreting and conveying a written score into sounding music. However, sometimes the communication of musical issues between musicians may be experienced as aggravating. In educational contexts in a broad sense, it might be advantageous if this communication could be facilitated, for example, by using visual illustrations as a complement to t
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Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E
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Defaulter tracing policies for Prevention of Mother-to-Child Transmission (PMTCT) services are vital for achieving the global goal of zero new HIV infections. However, little is known about their implementation. This qualitative study explores the role of tracers—community volunteers, retention workers, and mentor mothers—in implementing such policy across six facilities in Western Kenya. It uses
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The aim of the paper is to (re-)evaluate the treatment of reduplicative expressions as compound words in nearly all previous work on English. Examples of reduplicative expressions are listed, out of context, and they are labelled as compound words, without providing proper motivations as to why it makes sense to treat them as compounds, in the sense of lexical items that are formed of other lexica
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In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus. AMP containing cubosomes were produced by three different preparation protocols and compared: (i) pre-loading, where LL-37 was incorporated into a liquid
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Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors
Sharing session: "The Upheaval"
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There is mutual agreement that health care should be delivered according to need. In this article, although we employ different specifications for need, we conclude that there is inequity in the delivery of health care in Sweden. Higher income groups visit doctors more often than lower income groups in relation to need, but lower income groups remain in hospital longer once they have been admitted
